Phenotypic and functional dysregulated blood NK cells in Colorectal cancer patients can be activated by cetuximab plus IL-2 or IL-15.

Autor: Yamila Sol Rocca, María Paula Roberti, Estefanía Paula Juliá, María Betina Pampena, Luisina Bruno, Sergio Rivero, Eduardo Huertas, Fernando Sánchez Loria, Alejandro Pairola, Anne Caignard, José Mordoh, Estrella Mariel Levy

Publikováno v: Frontiers in Immunology, Vol 7 (2016)

The clinical outcome of colorectal cancer (CRC) is associated with the immune response, thus these tumors could be responsive to different immune therapy approaches. NK cells are key anti-tumor primary effectors that can eliminate CRC cells without p

Externí odkaz: https://doaj.org/article/fcdd73a7e1414aee999e29a609fdc510

Conditional recurrence-free survival of clinical complete responders managed by watch and wait after neoadjuvant chemoradiotherapy for rectal cancer in the International Watch & Wait Database: a retrospective, international, multicentre registry study

Autor: Angelita Habr-Gama, S. Ravi, R. Kushwaha, Zaman Z. Mamedli, Koen C.M.J. Peeters, Anna Martling, Elma Meershoek-Klein Kranenbarg, Geerard L. Beets, Arthur Sun Myint, S. Loganathan, Gustavo Rossi, Wolfgang Gaertner, S. Duff, J. Heat, D. Vimalchandran, Malcolm S Wilson, J. Hobbiss, K.H. Siddiqui, Krzysztof Bujko, Fernando Sanchez Loria, Maxime J M van der Valk, Rodrigo Oliva Perez, Marit E van der Sande, Renu R. Bahadoer, P. Mitchell, A. Blower, Jarno Melenhorst, Claudio Coco, J. Salaman, Guilherme Pagin São Julião, Denise E. Hilling, Oktar Asoglu, M.H. Solkar, S.H. Pettit, S.T. Dwyer, P. Vieira, Anders Jakobsen, N. Lees, Rita Barroca, Christopher M. Cunningham, Simon Gollins, S. Ward, Jean-Pierre Gerard, J. Epstein, James Hill, Albert Wolthuis, Nuno Figueiredo, A. Bhowmick, Nagarajan Pranesh, Nigel Scott, M. Braun, J. Harrison, Jing Zhang, Oriol Pares, André D’Hoore, R. Rajaganeshan, K. Riyad, R. Harris, Inês Santiago, Soledad Iseas, Paul E Fulford, Alejandro Pairola, Charlotte Verberne, B. Taylor, Des C. Winter, M. Paraoan, Annet G H Roodvoets, P. Carter, Harm J. T. Rutten, Fernando López Campos, Zhen Zhang, A. Abdelrazeq, Carlos A. Vaccaro, M. Saeed, C. Smart, Laura M. Fernandez, Carlijn Witjes, T.Y. Linn, K. Telford, Chelliah Selvasekar, D. Richards, Peirong Ding, J. Beveridge, D. Evans, Andrew G Renehan, Carlos Alfredo Lopes de Carvalho, Cornelis J.H. van de Velde, David R. Jones, Robert Madoff, Z. Huq, Sthela M. Murad-Regadas, Bruna Borba Vailati, Sarah T O'Dwyer, Klaus E. Matzel, Eduardo Huertas, L. Jones, U. Khan, S. Rawat, Gabriel Dimofte

Publikováno v: Lancet oncology, 22(1), 43-50. Elsevier Science
The Lancet Oncology, 22(1), 43-50. ELSEVIER SCIENCE INC
Lancet Oncology, 22(1), 43-50. Lancet Publishing Group

Summary Background Watch and wait is a novel management strategy in patients with rectal cancer who have a clinical complete response after neoadjuvant chemoradiotherapy. Surveillance of these patients is generally intensive, because local regrowth (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fa7ee224e61b596bc415c8f0974dea
https://doi.org/10.1016/s1470-2045(20)30557-x

Non-surgical management of rectal cancer. Series of 68 cases, long follow up in two leading centres in Argentina

Autor: Guillermo Mendez, J. O’Connor, Mariana Coraglio, M. Chacon, Alejandro Pairola, Eduardo Huertas, Enrique Roca, Adriana Dieguez, Soledad Iseas, Fernando Sanchez Loria, Javier Mariani

Publikováno v: Digestive and Liver Disease. 48:1372-1377

Background The non-surgical management in a selected group of rectal cancer patients has shown promising results with adequate follow up. Aims describing the results of the non-surgical management in patients with complete clinical response, with a c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e8ad2c3f2c504ec3fb429bd386d5c9
https://doi.org/10.1016/j.dld.2016.05.012

Altered phenotype in peripheral blood and tumor-associated NK cells from colorectal cancer patients

Autor: Juan Martín Arriaga, Eduardo Huertas, José Mordoh, Luisina Inés Bruno, Alejandro Pairola, Estrella Mariel Levy, Maria Paula Roberti, Michele Bianchini, Fernando Sanchez Loria, Mora Amat, Yamila S. Rocca, María Betina Pampena

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Despite NK cells being originally identified because of their ability to kill tumor cells in vitro, only limited information is available on NK cells infiltration of malignant tumors, especially in humans. NK cells infiltrating human colorectal carci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4014a22f6f4ecf7c9180c7dc0a25b682
https://pubmed.ncbi.nlm.nih.gov/22781631

Surgical salvage of pelvic recurrences from colorectal tumors

Autor: M. Chacon, F. Sanchez Loria, Maria Varela, R. D. Chacon, Carolina Chacón, J. O’Connor, Eduardo Huertas, Alejandro Pairola, Julio Kaplan, Enrique Roca

Publikováno v: Journal of Clinical Oncology. 24:13580-13580

13580 Background: The morbidity of pelvic recurrences from colorectal tumors (PRCT) represents a challenge for the oncology multidisciplinary team. Surgical treatment is the best option for palliation and in several series it offers long term local c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::202f39bea979c94e92ba99b7e55ceef8
https://doi.org/10.1200/jco.2006.24.18_suppl.13580