Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Alejandro P Adam"'
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161975 (2016)
Activation of Src Family Kinase (SFK) signaling is required for the increase in endothelial permeability induced by a variety of cytokines and growth factors. However, we previously demonstrated that activation of endogenous SFKs by expression of dom
Externí odkaz:
https://doaj.org/article/c1b9b95acf88468cb8ec40ca20eb1192
Autor:
Sharon J Sequeira, Aparna C Ranganathan, Alejandro P Adam, Bibiana V Iglesias, Eduardo F Farias, Julio A Aguirre-Ghiso
Publikováno v:
PLoS ONE, Vol 2, Iss 7, p e615 (2007)
Endoplasmic reticulum (ER) stress signaling can be mediated by the ER kinase PERK, which phosphorylates its substrate eIF2alpha. This in turn, results in translational repression and the activation of downstream programs that can limit cell growth th
Externí odkaz:
https://doaj.org/article/5bd8f5cda7d44318be48d63021b05a91
Publikováno v:
Skin Health and Disease, Vol 4, Iss 2, Pp n/a-n/a (2024)
Abstract Purpose Overactivation of the mitogen activated kinase pathway has been associated with rosacea. We hypothesised that inhibitors of this pathway can be repurposed to alleviate rosacea symptoms. Methods In order to test this hypothesis, we de
Externí odkaz:
https://doaj.org/article/ea293b365da94a9a835c3b6272f213df
Autor:
Apoorv Chebolu, Ramon Bossardi Ramos, Thilaka Arunachalam, Alejandro Pablo Adam, Edward J. Wladis
Publikováno v:
Skin Health and Disease, Vol 3, Iss 1, Pp n/a-n/a (2023)
Abstract Background Rosacea is a cutaneous disease that may secondarily affect the ocular surface. Due to the vision threatening, cosmetic, psychological, and work productivity impact, the identification of cellular targets that govern rosacea would
Externí odkaz:
https://doaj.org/article/4a7faee0fb664ac4bc61b31330068e59
Autor:
Nina Martino, Ramon Bossardi Ramos, Shuhan Lu, Kara Leyden, Lindsay Tomaszek, Sudeshna Sadhu, Gabrielle Fredman, Ariel Jaitovich, Peter A. Vincent, Alejandro P. Adam
Publikováno v:
JCI Insight, Vol 6, Iss 14 (2021)
SOCS3 is the main inhibitor of the JAK/STAT3 pathway. This pathway is activated by interleukin 6 (IL-6), a major mediator of the cytokine storm during shock. To determine its role in the vascular response to shock, we challenged mice lacking SOCS3 in
Externí odkaz:
https://doaj.org/article/0c99c2c81bfe447998ea6d2bf13bcda6
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C556-C569
Increased circulating levels of soluble interleukin (IL)-6 receptor α (sIL-6Rα) are commonly observed during inflammatory responses, allowing for IL-6 signaling in cells that express the ubiquitous receptor subunit gp130 but not IL-6Rα, such as en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b0452dc1125f5be91e7a09a196f24b
https://doi.org/10.1152/ajpcell.00171.2022
https://doi.org/10.1152/ajpcell.00171.2022
Autor:
Paloma Rodríguez‐Sevilla, Graham Spicer, Ana Sagrera, Alejandro P. Adam, Alejo Efeyan, Daniel Jaque, Sebastian A. Thompson
Measurement of intracellular temperature in a fast, accurate, reliable, and remote manner is crucial for the understanding of cellular processes. Nanothermometers based on the green fluorescence protein (GFP) are of special interest because intracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9958b00213a2047247fdc0193adbf4da
https://hdl.handle.net/10486/707720
https://hdl.handle.net/10486/707720
Autor:
Margarida Barroso, Alejandro P. Adam, Nina Martino, John Lamar, Janine Warren, Alena Rudkouskaya, Aditi Malhotra, Raymond Abini-Agbomson, Jamie Ward, Kate Tubbesing
Figure S1. Comparison of colocalization analysis coefficients, to support the colocalization approach and use of Pearson's coefficient as detailed in Supplementary Methods section entitled Colocalization analysis. Figure S2. Human mammary epithelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682880889e6e6668b5c43e557e2f309e
https://doi.org/10.1158/1541-7786.22516938.v1
https://doi.org/10.1158/1541-7786.22516938.v1
Autor:
Margarida Barroso, Alejandro P. Adam, Nina Martino, John Lamar, Janine Warren, Alena Rudkouskaya, Aditi Malhotra, Raymond Abini-Agbomson, Jamie Ward, Kate Tubbesing
Video S3. Live-cell Fast Airyscan Microscopy of EGF, LDL and Tf uptake and early trafficking steps in MCF10A and MDAMB231, corresponds to Figure 3D.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea7fbe5ef49995e986a666a269aaba6
https://doi.org/10.1158/1541-7786.22516929.v1
https://doi.org/10.1158/1541-7786.22516929.v1
Autor:
Margarida Barroso, Alejandro P. Adam, Nina Martino, John Lamar, Janine Warren, Alena Rudkouskaya, Aditi Malhotra, Raymond Abini-Agbomson, Jamie Ward, Kate Tubbesing
Video S2. Corresponds to Figure 2A. Created for visualization of MDAMB231 enlarged endosome with EEA1 (red) and Tf (green).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086610842b4c0a94fecde94fbbd44098
https://doi.org/10.1158/1541-7786.22516932.v1
https://doi.org/10.1158/1541-7786.22516932.v1