Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Alejandro Pérez-Pitarch"'
Publikováno v:
Revista Espanola de Enfermedades Digestivas, Vol 107, Iss 3, Pp 137-142 (2015)
Background: Infliximab, an anti-tumour necrosis factor approved for treatment of Crohn's disease and ulcerative colitis, is administered at predefined interdose-intervals. On insufficient response or loss of response, treatment can be intensified. Th
Externí odkaz:
https://doaj.org/article/44b7425ab7f14f6593b26781160eacac
Autor:
Rafael Ferriols-Lisart, Gerardo Aguilar, Alejandro Pérez-Pitarch, Jaume Puig, Carlos Ezquer-Garín, Manuel Alós
Publikováno v:
Critical Care, Vol 21, Iss 1, Pp 1-2 (2017)
Externí odkaz:
https://doaj.org/article/19362b374012479f8e340023728111ca
Publikováno v:
CPT: pharmacometricssystems pharmacologyREFERENCES.
As formal causal inference begins to play a greater role in disciplines that intersect with pharmacometrics, such as biostatistics, epidemiology, and artificial intelligence/machine learning, pharmacometricians may increasingly benefit from a basic f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff36d3360aa28f2937c10eeb1d08f981
https://pubmed.ncbi.nlm.nih.gov/36385744
https://pubmed.ncbi.nlm.nih.gov/36385744
Autor:
Andreas Gollner, Patrizia Sini, Dorothea Rudolph, Harald Weinstabl, Juergen Ramharter, Ulrike Weyer-Czernilofsky, Bojana Golubovic, Rolf Grempler, Alejandro Pérez Pitarch, Reinhard Sailer, Darryl B. McConnell, Norbert Kraut
Publikováno v:
Cancer Research. 83:LB003-LB003
The E3 ligase MDM2 controls the tumor suppressor function of p53, which is encoded by the TP53gene. Compounds designed to bind to MDM2 preventing its interaction with p53 restore the ability of p53 to combat the pathogenic processes that underly canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90bcdaa2b6dcdc26a73c23e8eaf178b5
https://doi.org/10.1158/1538-7445.am2023-lb003
https://doi.org/10.1158/1538-7445.am2023-lb003
Autor:
Mehul Mehta, Ramana S. Uppoor, Sreedharan Sabarinath, Alejandro Pérez-Pitarch, Gopichand Gottipati
Publikováno v:
Pharmaceutical research. 37(10)
To explore the use of a multistate repeated, time-to-categorical event model describing the frequency, severity and duration of migraines. Subject level data from patients in placebo arms from two efficacy trials for migraine-preventive treatments we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23280badb61f79519482cfdc48ec4a7b
https://pubmed.ncbi.nlm.nih.gov/32895855
https://pubmed.ncbi.nlm.nih.gov/32895855
Autor:
Alejandro Pérez-Pitarch, Wai Hong Man, Ingeborg Wilting, W. W. van Solinge, Alwin D. R. Huitema, Antoine C. G. Egberts, Eibert R. Heerdink
Publikováno v:
British Journal of Clinical Pharmacology. 84:1228-1237
Aims: Previously, we have reported an association between clozapine use and elevated FL3 neutrophil fluorescence, a flow-cytometric parameter for cell viability. Here, we developed and evaluated a pharmacokinetic-pharmacodynamic model relating FL3-fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4620ed33a95963a7440c8a6609f7f19
https://doi.org/10.1111/bcp.13546
https://doi.org/10.1111/bcp.13546
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 10, Pp 1386-1397 (2023)
Abstract We report use of a pharmacometrics enhanced Bayesian borrowing (PEBB) approach to leverage historical clinical trial data on a drug product to build models, project the outcome of future clinical trials, and borrow information from these pro
Externí odkaz:
https://doaj.org/article/a2a15bb0d6b84858b2ea1c7134523b06
Autor:
Virginia Merino, Beatriz Guglieri-López, Alejandro Pérez-Pitarch, Matilde Merino-Sanjuán, Amparo Nácher
Publikováno v:
Nutrition and Cancer. 69:555-563
The etiology of undernourishment in cancer patients is multifactorial: tumor-related mechanisms (such as obstruction, metabolic abnormalities, and functionality changes) in addition to the influence of anticancer therapies, which can induce or worsen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac14544bd3ff5a8039d0da2de4aa2922
https://doi.org/10.1080/01635581.2017.1299878
https://doi.org/10.1080/01635581.2017.1299878
Autor:
Matilde Merino-Sanjuán, Alejandro Pérez-Pitarch, Beatriz Guglieri-López, Amparo Nácher, Virginia Merino
Publikováno v:
Biopharmaceutics & Drug Disposition. 38:315-325
The main objective of this study was to develop a pharmacokinetic model in order to describe the intestinal absorption of erlotinib in rat and to quantify the interaction of levofloxacin on this process in well- and under-nourished rats. Absorption s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99361590d1b36d712c1462b7532ff5af
https://doi.org/10.1002/bdd.2065
https://doi.org/10.1002/bdd.2065
Autor:
Francisco Ferriols-Lisart, Pablo Calpe-Armero, Rafael Ferriols-Lisart, Alejandro Pérez-Pitarch
Publikováno v:
Chemotherapy. 62:374-380
Aims: To evaluate the effectiveness of nivolumab as second-line treatment compared to standard therapy with docetaxel in adult patients with non-small cell lung cancer (NSCLC) in clinical practice. Methods: This is an observational, retrospective coh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac2417263ef92eb7f5b2c6740cfcc55
https://doi.org/10.1159/000475803
https://doi.org/10.1159/000475803