Organic cation transporter 2 contributes to SSRI antidepressant efficacy by controlling tryptophan availability in the brain

Autor: Alejandro Orrico-Sanchez, Bruno P. Guiard, Stella Manta, Jacques Callebert, Jean-Marie Launay, Franck Louis, Antoine Paccard, Carole Gruszczynski, Catalina Betancur, Vincent Vialou, Sophie Gautron

Publikováno v: Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Selective serotonin reuptake inhibitors (SSRI) are common first-line treatments for major depression. However, a significant number of depressed patients do not respond adequately to these pharmacological treatments. In the present preclinic

Externí odkaz: https://doaj.org/article/d94a2324bd604020be6ec223f77ddc2a

Long-term impact of self-financed rotavirus vaccines on rotavirus-associated hospitalizations and costs in the Valencia Region, Spain

Autor: Alejandro Orrico-Sanchez, Mónica López-Lacort, Silvia Pérez-Vilar, Javier Díez-Domingo

Publikováno v: BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-8 (2017)

Abstract Background Rotavirus vaccines are available in Spain from 2007. They are recommended by the Spanish Pediatric Association, but not funded by the National Health System (NHS) and its coverage rate reached 40-50%. The hospitalization rate redu

Externí odkaz: https://doaj.org/article/dfbd9fdab2dd477296255454bb7f5907

Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression

Autor: Teodoro Zornoza, Franck Louis, Sara Rezai Amin, Rodolphe Alves de Sousa, Patrick M. Dansette, Carole Gruszczynski, Sophie Gautron, Vincent Vialou, Alejandro Orrico-Sanchez, Basile Coutens, Nicolas Pietrancosta, Francine Acher, Bruno P. Guiard, Laetitia Chausset-Boissarie, Assia Hessani, Bruno Giros

Publikováno v: Molecular Psychiatry
Molecular Psychiatry, Nature Publishing Group, 2019, ⟨10.1038/s41380-019-0548-4⟩
Molecular Psychiatry, 2020, 25 (6), pp.1245-1259. ⟨10.1038/s41380-019-0548-4⟩

International audience; Current antidepressants act principally by blocking monoamine reuptake by high-affinity transporters in the brain. However, these antidepressants show important shortcomings such as slow action onset and limited efficacy in ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359a2c1742a246517d0a349fbbcb63e7
https://hal.archives-ouvertes.fr/hal-02351247