Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Alejandro Orlowski"'
Autor:
Romina A. Di Mattía, Leandro A. Díaz Zegarra, Carlos A. Valverde, Paula G. Blanco, Carolina Jaquenod De Giusti, Enrique L. Portiansky, Ernesto A. Aiello, Alejandro Orlowski
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Cardiac cells depend on specific sarcolemmal ion transporters to assure the correct intracellular pH regulation. The sodium/bicarbonate cotransporter (NBC) is one of the major alkalinizing mechanisms. In the heart two different NBC isoforms have been
Externí odkaz:
https://doaj.org/article/cbe7f4c2928246eda1831fb4e6b1a347
Autor:
Alejandro Orlowski, Michael G. Katz, Sarah M. Gubara, Anthony S. Fargnoli, Kenneth M. Fish, Thomas Weber
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 192-203 (2020)
Gene therapy with adeno-associated virus (AAV)-based vectors shows great promise for the gene therapeutic treatment of a broad array of diseases. In fact, the treatment of genetic diseases with AAV vectors is currently the only in vivo gene therapy a
Externí odkaz:
https://doaj.org/article/15ad95b43f0f4dd189705de14587d1d1
Autor:
Estrella Lopez-Gordo, Alejandro Orlowski, Arthur Wang, Alan Weinberg, Susmita Sahoo, Thomas Weber
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Adeno-associated virus (AAV) vectors are promising candidates for gene therapy. However, a number of recent preclinical large animal studies failed to translate into the clinic. This illustrates the formidable challenge of choosing the animal models
Externí odkaz:
https://doaj.org/article/5d6874bcc86a4a70bf389ad654e266dd
Autor:
Miriam S. Giambelluca, María C. Ciancio, Alejandro Orlowski, Oscar A. Gende, Marc Pouliot, Ernesto A. Aiello
Publikováno v:
Cellular Physiology and Biochemistry, Vol 33, Iss 4, Pp 982-990 (2014)
Background: Bicarbonate transport has crucial roles in regulating intracellular pH (pHi) in a variety of cells. The purpose of this study was to evaluate its participation in the regulation of pHi in resting and stimulated human neutrophils. Methods:
Externí odkaz:
https://doaj.org/article/5160938ee5ec458384f1fc1b83965442
Autor:
Leandro M. Sommese, María Florencia Racioppi, Xin Shen, Alejandro Orlowski, Carlos A. Valverde, William E. Louch, Martín Vila Petroff, Luis A. Gonano
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 474:625-636
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81fd124f6bb14ffe68a09bf308e5ef6f
https://doi.org/10.1007/s00424-022-02678-8
https://doi.org/10.1007/s00424-022-02678-8
Autor:
Alejandro, Orlowski, Thomas, Weber
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2573
One of the greatest barriers for the use of adeno-associated vectors (AAV) in gene therapy is the presence of pre-existing antibodies against AAV in the general population. Since many of the anti-AAV antibodies have the ability to neutralize the tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5021e7f232f50a1b581eb27e7d6b5d2
https://pubmed.ncbi.nlm.nih.gov/36040599
https://pubmed.ncbi.nlm.nih.gov/36040599
Autor:
Carolina Jaquenod De Giusti, María Victoria Mencucci, Flavio Francini, María del Rosario González Baró, Martín Carlos Abba, Martin Vila Petroff, Sabrina Maria Luisa Lavarias, Nicolás Pedrini, Erica Vanesa Pereyra, Verónica Victoria Moscoso, Romina Canzoneri, Ernesto A. Aiello, Alejandro Orlowski, Noelia Costantini, Mauro Aldo Montanaro, Horacio A. Garda, Marianela Santana, Mauricio Nestor Kraemer
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
En diciembre de 2019, se produjo un nuevo brote de enfermedad por coronavirus (COVID-19) en Wuhan, China. El síndrome respiratorio agudo severo-coronavirus-2 (SARS-CoV-2), que es el séptimo coronavirus conocido que infecta a los humanos, es altamen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38304cb810489572df4d8fdde2676c8a
https://doi.org/10.24215/26838559e013
https://doi.org/10.24215/26838559e013
Autor:
Romina Di Mattía, Leandro Diaz-Zegarra, Paula Blanco, Carlos Valverde, Luis Gonano, Carolina Jaquenod De Giusti, Enrique Portiansky, Martin Vila-Petroff, Ernesto Aiello, Alejandro Orlowski
Two alkalinizing mechanisms coexist in cardiac myocytes in order to maintain the intracellular pH: sodium/bicarbonate cotransporter (electroneutral isoform NBCn1 and electrogenic isoform NBCe1) and sodium/proton exchanger (NHE1). The dysfunction of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5235f2937239475a9eb305e76026993
https://doi.org/10.21203/rs.3.rs-1292886/v1
https://doi.org/10.21203/rs.3.rs-1292886/v1
Autor:
Alejandro Orlowski, Thomas Weber
Publikováno v:
Methods in Molecular Biology ISBN: 9781071627068
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00bdf103aad4db03d9d84b15c00e6ec7
https://doi.org/10.1007/978-1-0716-2707-5_18
https://doi.org/10.1007/978-1-0716-2707-5_18
Autor:
Romina Di Mattia, Leandro Diaz Zegarra, Paula Blanco, Enrique Portiansky, Carlos Valverde, Luis Gonano, Carolina Jaquenod De Giusti, Ernesto Alejandro Aiello, Alejandro Orlowski
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c47817c9eb245b7e7f4345ab0ed6cc2
https://doi.org/10.1016/j.yjmcc.2022.08.054
https://doi.org/10.1016/j.yjmcc.2022.08.054