Phytosterols reverse antiretroviral-induced hearing loss, with potential implications for cochlear aging.

Autor: Alejandro O Sodero, Valeria C Castagna, Setiembre D Elorza, Sara M Gonzalez-Rodulfo, María A Paulazo, Jimena A Ballestero, Mauricio G Martin, María Eugenia Gomez-Casati

Publikováno v: PLoS Biology, Vol 21, Iss 8, p e3002257 (2023)

Cholesterol contributes to neuronal membrane integrity, supports membrane protein clustering and function, and facilitates proper signal transduction. Extensive evidence has shown that cholesterol imbalances in the central nervous system occur in agi

Externí odkaz: https://doaj.org/article/c767ae71c5a0473f80ca9fbe3649de3b

SIRT-1 Activity Sustains Cholesterol Synthesis in the Brain

Autor: Alejandro O. Sodero, Maria Alejandra Paulazo

Publikováno v: Neuroscience. 476

SIRT-1 is a potent energy regulator that has been implicated in the aging of different tissues, and cholesterol synthesis demands high amounts of cellular adenosine triphosphate. An efficient synaptic transmission depends on processes that are highly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1635a3dfc7c932288b72379388162a
https://pubmed.ncbi.nlm.nih.gov/34600072

Analysis of cholesterol in mouse brain by HPLC with UV detection

Autor: Alejandro O. Sodero, Maria Alejandra Paulazo

Publikováno v: PLoS ONE. 2020, 15(1): e0228170
PLoS ONE, Vol 15, Iss 1, p e0228170 (2020)
PLoS ONE
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA

We describe a sensitive high performance liquid chromatography (HPLC)-based method for the determination of cholesterol in brain tissue. The method does not require the derivatization of the analyte and uses separation and quantification by reversed-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a7be115ad93aca80cc4cf7a942bbb2
https://repositorio.uca.edu.ar/handle/123456789/10232

Sab is differentially expressed in the brain and affects neuronal activity

Autor: Chiara Salio, Monica Rodriguez-Silva, Alejandro O. Sodero, Marco Sassoè-Pognetto, Jeremy W. Chambers

Publikováno v: Brain Research. 2017;1670:76-85
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA

Fil: Sodero, Alejandro Omar. Florida International University. Herbert Wertheim College of Medicine. Department of Cellular Biology and Pharmacology; Estados Unidos Fil: Sodero, Alejandro Omar. Pontificia Universidad Católica Argentina. Facultad de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09747d9abe02c5bde3a3b2326f61919
http://hdl.handle.net/2318/1647281

Oxidative stress activates the pro-survival TrkA pathway through membrane cholesterol loss

Autor: Carlos G. Dotti, Alejandro O. Sodero, Maria Dolores Ledesma, Francesca Iannilli

Publikováno v: Neurobiology of Aging. 32:1033-1042

Neuronal activity is a highly demanding energetic process, resulting in the gradual accumulation of reactive oxygen species (ROS). Despite comparatively weak anti-oxidant defence systems, neurons outlive the pressure of ROS by activating most robust

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a0a3f7a17542a0ad6ad0bbfb78a6c1
https://doi.org/10.1016/j.neurobiolaging.2009.07.006