Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alejandro Nieto-Orellana"'
Autor:
Marco Di Antonio, Snow Stolnik, Alejandro Nieto-Orellana, Franco H. Falcone, Nick Childerhouse, Cynthia Bosquillon, Giuseppe Mantovani, Claudia Conte
Publikováno v:
Polymer Chemistry. 8:2210-2220
Non-covalent polymer-protein conjugation is emerging as a potential route to improve pharmacokinetics and pharmacodynamics of protein therapeutics. In this study, a family of structurally related block copolymers of mPEG2k - poly(glutamic acid) with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c693ff2369ab5bc25f3e17ef7de40fb
https://doi.org/10.1039/c7py00169j
https://doi.org/10.1039/c7py00169j
Autor:
Alejandro Nieto-Orellana, Nick Childerhouse, H. Li, Cynthia Bosquillon, Gemma Keegan, Nathalie Wauthoz, Hywel C Williams, Rémi Rosiere, Cíntia J. Monteiro, Snow Stolnik, David Coghlan, Giuseppe Mantovani
Publikováno v:
Journal of controlled release, 316
Pulmonary delivery is increasingly seen as an attractive, non-invasive route for the delivery of forthcoming protein therapeutics. In this context, here we describe protein complexes with a new ‘complexing excipient’ - vitamin B12-targeted poly(e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c022c0feca5c56d0625b6082da33e155
https://pubmed.ncbi.nlm.nih.gov/31678655
https://pubmed.ncbi.nlm.nih.gov/31678655
Autor:
Malcolm Rothery, David Coghlan, Alejandro Nieto-Orellana, Cynthia Bosquillon, Nick Childerhouse, Giuseppe Mantovani, Franco H. Falcone, Snow Stolnik
Pulmonary delivery of protein therapeutics has considerable clinical potential for treating both local and systemic diseases. However, poor protein conformational stability, immunogenicity and protein degradation by proteolytic enzymes in the lung ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f63b0ed9cee9057af6f105439102d91
Autor:
José Hureaux, Alejandro Nieto Orellana, Jérôme Bejaud, Anna Cieślak, Jean-Pierre Benoit, Claudio J. Salomon, Nathalie Wauthoz, Michel Lafleur, Nolwenn Lautram, Guillaume Bastiat
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics
European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2017, 115, pp.31-38. ⟨10.1016/j.ejpb.2017.02.008⟩
European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2017, 115, pp.31-38. ⟨10.1016/j.ejpb.2017.02.008⟩
Sterosomes (STEs), a new and promising non-phospholipidic liposome platform based on palmitic acid (PA) and cholesterol (Chol) mixtures, need to have polyethylene glycol (PEG) chains grafted to their surface in order to obtain long-circulating nanoca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2424767992572d3c94375c3be219b45c
https://hal.univ-angers.fr/hal-02515689
https://hal.univ-angers.fr/hal-02515689
Autor:
Marion J. Limo, Amanda Hüsler, Martin C. Garnett, Andrew L. Hook, Morgan R. Alexander, Robert Cavanagh, Jiraphong Suksiriworapong, Dipak Gordhan, Alejandro Nieto-Orellana, Claudia Conte, Jonathan C. Burley, Phil M. Williams, Cameron Alexander, Benoit Couturaud, Vincenzo Taresco, Amanda K. Pearce, Ioanna Danai Styliari
Publikováno v:
Macromolecular Materials and Engineering. 303:1800146
The self‐assembly of specific polymers into well‐defined nanoparticles (NPs) is of great interest to the pharmaceutical industry as the resultant materials can act as drug delivery vehicles. In this work, a high‐throughput method to screen the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cc49bd162588de5b27e8e02963311b7
https://doi.org/10.1002/mame.201800146
https://doi.org/10.1002/mame.201800146
Autor:
Michel Lafleur, Alejandro Nieto Orellana, Jean-Pierre Benoit, Zhong-Kai Cui, Katarina Edwards, Guillaume Bastiat
Publikováno v:
Journal of Colloid and Interface Science
Journal of Colloid and Interface Science, Elsevier, 2014, 428, pp.111-120. ⟨10.1016/j.jcis.2014.04.031⟩
Journal of Colloid and Interface Science, Elsevier, 2014, 428, pp.111-120. ⟨10.1016/j.jcis.2014.04.031⟩
Hypothesis Liposomes made of single-chain amphiphiles and a large amount of sterols display several advantages including a limited permeability. In the present paper, we examine the possibility to prepare such non-phospholipid liposomes with interfac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52554a62770202012e0f66119143ca0
https://hal.univ-angers.fr/hal-02523252
https://hal.univ-angers.fr/hal-02523252
Autor:
Styliari, Ioanna D.1, Conte, Claudia1, Pearce, Amanda K.1, Hüsler, Amanda1, Cavanagh, Robert J.1, Limo, Marion J.2, Gordhan, Dipak1, Nieto‐Orellana, Alejandro1, Suksiriworapong, Jiraphong3, Couturaud, Benoit1, Williams, Phil1, Hook, Andrew L.1, Alexander, Morgan R.1, Garnett, Martin C.1, Alexander, Cameron1 cameron.alexander@nottingham.ac.uk, Burley, Jonathan C.1 jonathan.burley@nottingham.ac.uk, Taresco, Vincenzo1 vincenzo.taresco@nottingham.ac.uk
Publikováno v:
Macromolecular Materials & Engineering. Aug2018, Vol. 303 Issue 8, p1-1. 9p.
Autor:
Pinto, J T, Radivojev, S, Fröhlich, E, Paudel, A, Lipworth, Brian, Vehring, Reinhard, Sheikh, Zara, Ong, Hui Xin, Pozzoli, Michele, Young, Paul, Traini, Daniela, Hellfritzsch, Marie, Scherlieβ, Regina, Gutowski, Tobias, Elserfy, K., Cheng, S., Chan, H-K., Hebbink, G., Mehta, M., Kourmatzis, A.
Publikováno v:
Journal of Aerosol Medicine & Pulmonary Drug Delivery; Apr2019, Vol. 32 Issue 2, pA-1-A-27, 27p
Publikováno v:
Polymer Chemistry; 4/14/2017, Vol. 8 Issue 14, p2127-2132, 6p
Autor:
Nieto-Orellana, Alejandro, Di Antonio, Marco, Conte, Claudia, Falcone, Franco H., Bosquillon, Cynthia, Childerhouse, Nick, Mantovani, Giuseppe, Stolnik, Snow
Publikováno v:
Polymer Chemistry; 4/14/2017, Vol. 8 Issue 14, p2210-2220, 11p