Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alejandro Manchado"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1880-1893 (2024)
The concept of bioisostere replacement is of paramount importance in medicinal chemistry, as it can be employed as a rational to expand bioactive chemical space to tackle lead optimization issues like lack of potency, efficacy, and selectivity or pha
Externí odkaz:
https://doaj.org/article/dcf21fb89c64495497cc814b170f7757
Publikováno v:
Molbank, Vol 2023, Iss 1, p M1544 (2023)
(S)-N1,N3-dibenzyl-1-cyclohexyl-N1,N3-bis((R)-1-phenylethyl)propane-1,3-diamine was prepared in good yield by the reduction of the corresponding amide, which was obtained by the addition of a chiral lithium amide to an α,β-unsaturated ester. The ta
Externí odkaz:
https://doaj.org/article/68a9e83d7cbb45b4b345a88459d4847f
Autor:
Ángel García-González, Leland Belda, Alejandro Manchado, Carlos T. Nieto, Narciso Martín Garrido
Publikováno v:
Molbank, Vol 2023, Iss 1, p M1561 (2023)
The preparation and characterization of a new chiral tertiary dibenzylamine are described. These molecules are well known in the literature for their high neuropharmacological potential. The general synthetic pathway is based on asymmetric Aza–Mich
Externí odkaz:
https://doaj.org/article/fe458247b64240f88fc75cfb491c70b5
Publikováno v:
Molecules, Vol 28, Iss 2, p 855 (2023)
A concise review covering updated presence and role of 2-phenethylamines in medicinal chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are enumerated in key therapeutic targets, listing medicinal chemistry hits a
Externí odkaz:
https://doaj.org/article/e658490f37304b518006caf806f4fdd9
Autor:
Alejandro Manchado, Mateo M. Salgado, Álvaro Vicente, David Díez, Francisca Sanz, Narciso M. Garrido
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 73, Iss 4, Pp 503-506 (2017)
The title compound, C22H25NO5, was prepared by CAN [cerium(IV) ammonium nitrate] oxidation of the corresponding β-lactam. The dihedral angle between the benzene rings is 13.3 (4)° and the C—N—C(=O)—C torsion angle is 176.1 (6)°. In the cryst
Externí odkaz:
https://doaj.org/article/53a5b25e35734c84a1ba4b0f0de4babe
Publikováno v:
Molecules, Vol 26, Iss 11, p 3107 (2021)
Ezetimibe is a well-known drug that lowers blood cholesterol levels by reducing its absorption in the small intestine when joining to Niemann-Pick C1-like protein (NPC1L1). A ligand-based study on ezetimibe analogues is reported, together with one-hi
Externí odkaz:
https://doaj.org/article/6dbcac351ae84174ae6eb55208b8667c
Publikováno v:
Molecules, Vol 25, Iss 6, p 1308 (2020)
The asymmetric synthesis of a compound with the cyclopentan[c]pyran core of iridoid natural products in four steps and 40% overall yield is reported. Our methodology includes a one-pot tandem domino reaction which provides a trisubstituted cyclopenta
Externí odkaz:
https://doaj.org/article/43bd0cab8428473ea1db5228c6d1b89e
Publikováno v:
Synlett. 31:600-604
A convenient asymmetric synthesis of methyl (2S,3S,6R)-6-(4-fluorophenyl)-2-(4-hydroxyphenyl)-piperidine-3-carboxylate is described, starting from Baylis–Hillman adducts. The route involves a domino process: allylic acetate rearrangement, stereosel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86e67ea9621d9d39e2e1ff13793db863
https://doi.org/10.1055/s-0039-1690990
https://doi.org/10.1055/s-0039-1690990
Autor:
Alejandro Manchado Cascón
Publikováno v:
GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname
instname
[ES]La presente tesis se basa en la aplicación diferentes metodologías para la síntesis de diferentes estructuras bioactivas: -Metodología de adición de amiduros de litio quirales: a través de la cual se obtienen beta-aminoácidos quirales con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f4321e649d0015d7dcd7d99001d85f
https://doi.org/10.14201/gredos.148900
https://doi.org/10.14201/gredos.148900
Publikováno v:
Tetrahedron. 74:5240-5247
A novel 1,4-Phenyl radical rearrangement (1,4-PhRR) is described in a typical Barton decarboxylation procedure. While carrying out this reaction in presence of a N,N-disubstituted β-amino acid derivative, the decarboxyphenyl rearranged derivative is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea90b493e9a263fc5ed28a3b704ab803
https://doi.org/10.1016/j.tet.2018.05.043
https://doi.org/10.1016/j.tet.2018.05.043