Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alejandro M. Chibly"'
Autor:
Nayan Chaudhary, Alejandro M. Chibly, Ann Collier, Jorge Martinalbo, Pablo Perez-Moreno, Heather M. Moore, Patricia Luhn, Ciara Metcalfe, Marc Hafner
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract As CDK4/6 inhibitor (CDK4/6i) approval changed treatment strategies for patients with hormone receptor-positive HER2-negative (HR+/HER2-) breast cancer (BC), understanding how exposure to CDK4/6i affects the tumor genomic landscape is critic
Externí odkaz:
https://doaj.org/article/150abe257c594c719c7fd97eca5f49ee
Autor:
Alejandro M. Chibly, Vaishali N. Patel, Marit H. Aure, Mary C. Pasquale, NIDCD/NIDCR Genomics and Computational Biology Core, Gemma E. Martin, Mousa Ghannam, Julianne Andrade, Noah G. Denegre, Colleen Simpson, David P. Goldstein, Fei-Fei Liu, Isabelle M. A. Lombaert, Matthew P. Hoffman
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-16 (2023)
Abstract The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive. Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin signaling is highly disrupted post-radiation. Neurotrophin receptors (
Externí odkaz:
https://doaj.org/article/129281bde15944a19f2677ecbebb4c69
Autor:
Brenna A. Rheinheimer, Mary C. Pasquale, Kirsten H. Limesand, Matthew P. Hoffman, Alejandro M. Chibly
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106660- (2023)
Summary: Understanding the transcriptional landscape that results in chronic salivary hypofunction after irradiation will help identify injury mechanisms and develop regenerative therapies. We present scRNA-seq analysis from control and irradiated mu
Externí odkaz:
https://doaj.org/article/f4994bd5e8e9474da7d59249fce31b94
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101838- (2020)
Summary: Understanding the dynamic transcriptional landscape throughout organ development will provide a template for regenerative therapies. Here, we generated a single-cell RNA sequencing atlas of murine submandibular glands identifying transcripti
Externí odkaz:
https://doaj.org/article/fe52e4901fc047879e64dc8f04e94533
Publikováno v:
Physiol Rev
Salivary glands produce and secrete saliva, which is essential for maintaining oral health and overall health. Understanding both the unique structure and physiological function of salivary glands, as well as how they are affected by disease and inju
Autor:
Alejandro M. Chibly, Tharu M. Fernando, Ciara Metcalfe, Marc Hafner, Gilbert Owusu-Manu, Sara Hurvitz, Aditya Bardia, Peter A. Fasching, Yeon H. Park, Vanesa Quiroga, Jutta Steinseifer, Pablo Perez-Moreno, Heather M. Moore
Publikováno v:
Cancer Research. 83:PD13-02
Background: Endocrine therapy remains the mainstay treatment for ER+ BC. CDK4/6 inhibitors induce cell cycle arrest and decrease tumor cell proliferation, as measured by the biomarker Ki67, when used in combination with aromatase inhibitors (AI) such
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107893 (2014)
Radiotherapy is the primary treatment for patients with head and neck cancer, which account for roughly 500,000 annual cases worldwide. Dysfunction of the salivary glands and associated conditions like xerostomia and dysphagia are often developed by
Externí odkaz:
https://doaj.org/article/a1e6813af0c745cd94e19d90763b601a
Autor:
Belinda R. Hauser, Elsa H. Berenstein, Vaishali N. Patel, Corinne M. Goldsmith, Yuefan Song, Dallas L. Pineda, Changyu Zheng, Robert J. Linhardt, Michaela Prochazkova, Ashok B. Kulkarni, Sophie Choi, Matthew P. Hoffman, Toin H. van Kuppevelt, Alejandro M. Chibly
Publikováno v:
Matrix Biology, 103, 37-57
Matrix Biol
Matrix Biology, 103, pp. 37-57
Matrix Biol
Matrix Biology, 103, pp. 37-57
Heparan sulfate 3-O-sulfotransferases generate highly sulfated but rare 3-O-sulfated heparan sulfate (HS) epitopes on cell surfaces and in the extracellular matrix. Previous ex vivo experiments suggested functional redundancy exists among the family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a68883c3c7b9073f3123334e10318d
http://hdl.handle.net/2066/241114
http://hdl.handle.net/2066/241114
Autor:
Matthew P. Hoffman, Marit H. Aure, Alejandro M. Chibly, Michael C. Kelly, Belinda R. Hauser, Genomics Biology Core
Publikováno v:
SSRN Electronic Journal.
Understanding the dynamic transcriptional landscape throughout organ development will provide a template for regenerative therapies. Here, we generated a single-cell RNAseq atlas of murine submandibular glands identifying transcriptional profiles ass