Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Alejandro Lopez-Ramirez"'
Autor:
Karthik Ashok, Tyra Martinez, Julie Sesen, Sana Nasim, Shih-Shan Lang, Gregory Heuer, Alexander Tucker, Miguel Alejandro Lopez-Ramirez, Edward R. Smith, Aram Ghalali
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionCerebral cavernous malformations (CCMs) are pathologic lesions comprised of clusters of thin-walled capillaries characterized by abnormal proliferation, angiogenesis, and bleeding secondary to somatic or germline mutations in endothelial
Externí odkaz:
https://doaj.org/article/ee79889bef1142a6b7720f85d260a626
Autor:
Miguel Alejandro Lopez‐Ramirez, Sara McCurdy, Wenqing Li, Mark K. Haynes, Preston Hale, Karol Francisco, Killian Oukoloff, Matthew Bautista, Chelsea H.J. Choi, Hao Sun, Brendan Gongol, John Y. Shyy, Carlo Ballatore, Larry A. Sklar, Alexandre R. Gingras
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 5, Pp 334-355 (2021)
ABSTRACT The transmembrane protein heart of glass1 (HEG1) directly binds to and recruits Krev interaction trapped protein 1 (KRIT1) to endothelial junctions to form the HEG1–KRIT1 protein complex that establishes and maintains junctional integrity.
Externí odkaz:
https://doaj.org/article/12d216681c9e4a0d9063a1dd1f6e713e
Autor:
Hao Sun, Wun Kuk, Jesús Rivera-Nieves, Miguel Alejandro Lopez-Ramirez, Lars Eckmann, Mark H. Ginsberg
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 369-385 (2020)
Background & Aims: Integrin α4β7 mediates lymphocyte trafficking to the gut and gut-associated lymphoid tissues, a process critical for recruitment of effector lymphocytes from the circulation to the gut mucosa in inflammatory bowel disease (IBD) a
Externí odkaz:
https://doaj.org/article/a61a7763d7044b87872bab3838b45c32
Autor:
Catherine Chinhchu Lai, Bliss Nelsen, Eduardo Frias-Anaya, Helios Gallego-Gutierrez, Marco Orecchioni, Victoria Herrera, Elan Ortiz, Hao Sun, Omar A. Mesarwi, Klaus Ley, Brendan Gongol, Miguel Alejandro Lopez-Ramirez
Publikováno v:
Circulation Research. 131:909-925
Background: Cerebral cavernous malformations (CCMs) are neurovascular lesions caused by loss of function mutations in 1 of 3 genes, including KRIT1 (CCM1 ), CCM2 , and PDCD10 (CCM3 ). CCMs affect ≈1 out of 200 children and adults, and no pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300eda3dcbd44ddd4e0dfac0cffb101d
https://doi.org/10.1161/circresaha.122.321129
https://doi.org/10.1161/circresaha.122.321129
Autor:
Carlos Galicia Aguirre, Kizito-Tshitoko Tshilenge, Elena Battistoni, Alejandro Lopez-Ramirez, Swati Naphade, Kevin Perez, Sicheng Song, Sean D. Mooney, Simon Melov, Michelle E. Ehrlich, Lisa M. Ellerby
SUMMARYHuntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of CAG repeats in exon 1 of theHTTgene, ultimately resulting in the generation of a mutant HTT (mHTT) protein. Although mHTT is expressed in various tissues, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2bf30d3828038869b311787fb28c25a
https://doi.org/10.1101/2023.04.30.538872
https://doi.org/10.1101/2023.04.30.538872
Autor:
Sara McCurdy, Jenny Lin, Robert Shenkar, Thomas Moore, Rhonda Lightle, Eva Faurobert, Miguel‐Alejandro Lopez‐Ramirez, Issam Awad, Mark H. Ginsberg
Publikováno v:
FASEB Journal
FASEB Journal, 2022, 36 (12), pp.e22629. ⟨10.1096/fj.202200907RR⟩
FASEB Journal, 2022, 36 (12), pp.e22629. ⟨10.1096/fj.202200907RR⟩
International audience; β1 integrins are important in blood vessel formation and function, finely tuning the adhesion of endothelial cells to each other and to the extracellular matrix. The role of integrins in the vascular disease, cerebral caverno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816ea76eaad7290896f9d0d1b2bfd199
https://pubmed.ncbi.nlm.nih.gov/36349990
https://pubmed.ncbi.nlm.nih.gov/36349990
Autor:
Kizito-Tshitoko Tshilenge, Carlos Galicia Aguirre, Joanna Bons, Akos A. Gerencser, Nathan Basisty, Sicheng Song, Jacob Rose, Alejandro Lopez-Ramirez, Swati Naphade, Ashley Loureiro, Elena Battistoni, Mateus Milani, Cameron Wehrfritz, Anja Holtz, Claudio Hetz, Sean D. Mooney, Birgit Schilling, Lisa M. Ellerby
Publikováno v:
Molecular & Cellular Proteomics. 22:100534
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b07d104c416da281cd3b496facec2a5
https://doi.org/10.1016/j.mcpro.2023.100534
https://doi.org/10.1016/j.mcpro.2023.100534
Autor:
Kizito-Tshitoko Tshilenge, Carlos Galicia Aguirre, Joanna Bons, Nathan Basisty, Sicheng Song, Jacob Rose, Alejandro Lopez-Ramirez, Akos Gerencser, Swati Naphade, Ashley Loureiro, Cameron Wehrfritz, Anja Holtz, Sean Mooney, Birgit Schilling, Lisa M. Ellerby
Huntington’s disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin (HTT) gene. The resulting polyglutamine (polyQ) tract alters the function of the HTT protein. Although HTT is expressed in different tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35cc2d409512eb1274722f40f094429f
https://doi.org/10.1101/2022.05.11.491152
https://doi.org/10.1101/2022.05.11.491152
Autor:
Miguel Alejandro Lopez-Ramirez, David S. Paul, Mark H. Ginsberg, Monica N. Cuevas, Hao Sun, Jenny Lin, Andrew J. Valadez, Wolfgang Bergmeier, Frederic Lagarrigue, Jailal N. G. Ablack, Alexandre R. Gingras
Publikováno v:
ORCID
Microsoft Academic Graph
PubMed Central
Blood
Blood, American Society of Hematology, 2020, 136 (10), pp.1180-1190. ⟨10.1182/blood.2020005348⟩
Microsoft Academic Graph
PubMed Central
Blood
Blood, American Society of Hematology, 2020, 136 (10), pp.1180-1190. ⟨10.1182/blood.2020005348⟩
Ras-related protein 1 (Rap1) is a major convergence point of the platelet-signaling pathways that result in talin-1 binding to the integrin β cytoplasmic domain and consequent integrin activation, platelet aggregation, and effective hemostasis. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df7a78738c71146bcb8a0181c3d48a5
https://www.sciencedirect.com/science/article/pii/S0006497120617487
https://www.sciencedirect.com/science/article/pii/S0006497120617487
Autor:
Lars Eckmann, Miguel Alejandro Lopez-Ramirez, Wun Kuk, Mark H. Ginsberg, Hao Sun, Jesus Rivera-Nieves
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 369-385 (2020)
Cellular and molecular gastroenterology and hepatology, vol 9, iss 3
Cellular and molecular gastroenterology and hepatology, vol 9, iss 3
Background & Aims: Integrin α4β7 mediates lymphocyte trafficking to the gut and gut-associated lymphoid tissues, a process critical for recruitment of effector lymphocytes from the circulation to the gut mucosa in inflammatory bowel disease (IBD) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8864719b3e3f558c08c008a680ee6a9
http://www.sciencedirect.com/science/article/pii/S2352345X19301481
http://www.sciencedirect.com/science/article/pii/S2352345X19301481