Výsledky vyhledávání - "Alejandro J Cagnoni"

Akademický článek

A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection

Publikováno v: mBio, Vol 13, Iss 4 (2022)

ABSTRACT Combined Antiretroviral therapy (cART) suppresses HIV replication but fails to eradicate the virus, which persists in a small pool of long-lived latently infected cells. Immune activation and residual inflammation during cART are considered

Externí odkaz: https://doaj.org/article/e9d71457b2f84f5da38d7bf12b2e8d3e

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The disulfide bond as a key motif for the construction of multivalent glycoclusters

Autor: María Emilia Cano, Walter Emiliano Jara, Alejandro J. Cagnoni, Emmanuel Brizzio, Miriam C. Strumia, Evangelina Repetto, María Laura Uhrig

Publikováno v: New Journal of Chemistry. 46:17682-17695

S-Glycosylated dendrons having a thioacetate group in their focal points led to multivalent glycoclusters by spontaneous O2-oxidation of sulfides.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f247417cdd7f3e2f2afed7a82f70a3b
https://doi.org/10.1039/d2nj03071c

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Circulating galectin-1 delineates response to bevacizumab in melanoma patients and reprograms endothelial cell biology

Autor: Nadia Bannoud, Juan C. Stupirski, Alejandro J. Cagnoni, Pablo F. Hockl, Juan M. Pérez Sáez, P. Alfredo García, Yamil D. Mahmoud, Julián Gambarte Tudela, Marco A. Scheidegger, Andrea Marshall, Pippa G. Corrie, Mark R. Middleton, Karina V. Mariño, M. Romina Girotti, Diego O. Croci, Gabriel A. Rabinovich

Publikováno v: Proceedings of the National Academy of Sciences. 120

Blockade of vascular endothelial growth factor (VEGF) signaling with bevacizumab, a humanized anti-VEGF monoclonal antibody (mAb), or with receptor tyrosine kinase inhibitors, has improved progression-free survival and, in some indications, overall s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a727eb804e92171df0100b5226113f4a
https://doi.org/10.1073/pnas.2214350120

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Akademický článek

Synthesis of divalent ligands of β-thio- and β-N-galactopyranosides and related lactosides and their evaluation as substrates and inhibitors of Trypanosoma cruzi trans-sialidase

Autor: María Emilia Cano, Rosalía Agusti, Alejandro J. Cagnoni, María Florencia Tesoriero, José Kovensky, María Laura Uhrig, Rosa M. de Lederkremer

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 3073-3086 (2014)

In this work we describe the synthesis of mono- and divalent β-N- and β-S-galactopyranosides and related lactosides built on sugar scaffolds and their evaluation as substrates and inhibitors of the Trypanosoma cruzi trans-sialidase (TcTS). This enz

Externí odkaz: https://doaj.org/article/382ed49104c842c2ab0e4a7a3ec35208

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Synthesis ofN-acetylglucosamine andN-acetylallosamine resorcinarene-based multivalent β-thio-glycoclusters: unexpected affinity ofN-acetylallosamine ligands towards Wheat Germ Agglutinin

Autor: Alejandro J. Cagnoni, María Laura Uhrig, Alejandro Ezequiel Cristófalo

Publikováno v: Organic & Biomolecular Chemistry. 18:6853-6865

Herein, we report the synthesis of calix[4]resorcinarene-based multivalent ligands bearing β-S-GlcNAc and β-S-AllNAc recognition elements. A clickable β-S-AllNAc derivative was successfully prepared from a β-thioalkynyl GlcNAc precursor, making u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56468f4ffddba60a3f6c983b7a13d39
https://doi.org/10.1039/d0ob01498b

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Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits

Autor: Juan M. Pérez-Sáez, Alejandro J. Cagnoni, Luciano Gastón Morosi, María Romina Girotti, Sergio P. Huernos, Betiana Pucci, Montana N. Manselle-Cocco, Marta A. Toscano, Anibal H. Gil, Gabriel A. Rabinovich, Alicia M. Sambuelli, Rosa M. Morales, Joaquín P. Merlo, Maria May, Guillermo Horacio Docena, Anabela M. Cutine, Karina Mariño, Diego O. Croci, Santiago P. Méndez-Huergo

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Science Advances
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Diverse immunoregulatory circuits operate to preserve intestinal homeostasis and prevent inflammation. Galectin-1 (Gal1), a β-galactoside-binding protein, promotes homeostasis by reprogramming innate and adaptive immunity. Here, we identify a glycos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be6115415da18b68a5335dc831c129b
http://sedici.unlp.edu.ar/handle/10915/124604

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Dual knockdown of Galectin-8 and its glycosylated ligand, the activated leukocyte cell adhesion molecule (ALCAM/CD166), synergistically delays in vivo breast cancer growth

Autor: Karina Mariño, Fátima Ferragut, María T. Elola, Silvia Vanzulli, Lucas L. Colombo, Clara Sanchez Terrero, Gabriel A. Rabinovich, María F. Troncoso, Carlota Wolfenstein-Todel, Alejandro J. Cagnoni

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Galectin-8 (Gal-8), a ‘tandem-repeat’-type galectin, has been described as a modulator of cellular functions including adhesion, spreading, growth arrest, apoptosis, pathogen recognition, autophagy, and immunomodulation. We have previously shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6989e39ebbcb02f2f3d1314979d8f5
https://doi.org/10.1016/j.bbamcr.2019.03.010

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