Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Alejandro Gella"'
Autor:
Emma Puighermanal, Marta Luna-Sánchez, Alejandro Gella, Gunter van der Walt, Andrea Urpi, María Royo, Paula Tena-Morraja, Isabella Appiah, Maria Helena de Donato, Fabien Menardy, Patrizia Bianchi, Anna Esteve-Codina, Laura Rodríguez-Pascau, Cristina Vergara, Mercè Gómez-Pallarès, Giovanni Marsicano, Luigi Bellocchio, Marc Martinell, Elisenda Sanz, Sandra Jurado, Francesc Xavier Soriano, Pilar Pizcueta, Albert Quintana
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Mutations in mitochondrial energy-producing genes lead to a heterogeneous group of untreatable disorders known as primary mitochondrial diseases (MD). Leigh syndrome (LS) is the most common pediatric MD and is characterized by progressive ne
Externí odkaz:
https://doaj.org/article/622861ac6cc14a5babd24370dd72d435
Autor:
Alejandro Gella, Patricia Prada-Dacasa, Montserrat Carrascal, Andrea Urpi, Melania González-Torres, Joaquin Abian, Elisenda Sanz, Albert Quintana
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Defects in mitochondrial function lead to severe neuromuscular orphan pathologies known as mitochondrial disease. Among them, Leigh Syndrome is the most common pediatric presentation, characterized by symmetrical brain lesions, hypotonia, motor and r
Externí odkaz:
https://doaj.org/article/2ee59d68877041839468b29143c278fb
Autor:
Irene Bolea, Alejandro Gella, Elisenda Sanz, Patricia Prada-Dacasa, Fabien Menardy, Angela M Bard, Pablo Machuca-Márquez, Abel Eraso-Pichot, Guillem Mòdol-Caballero, Xavier Navarro, Franck Kalume, Albert Quintana
Publikováno v:
eLife, Vol 8 (2019)
Mitochondrial deficits in energy production cause untreatable and fatal pathologies known as mitochondrial disease (MD). Central nervous system affectation is critical in Leigh Syndrome (LS), a common MD presentation, leading to motor and respiratory
Externí odkaz:
https://doaj.org/article/32bf3e6cbd584e239e67faa01e0f2b0e
Autor:
Byron Chen, Jessica Hui, Kelsey S. Montgomery, Alejandro Gella, Irene Bolea, Elisenda Sanz, Richard D. Palmiter, Albert Quintana
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Inability of mitochondria to generate energy leads to severe and often fatal myoencephalopathies. Among these, Leigh syndrome (LS) is one of the most common childhood mitochondrial diseases; it is characterized by hypotonia, failure to thrive, respir
Externí odkaz:
https://doaj.org/article/289cace627004ee8a388e83c0f727295
Publikováno v:
Neurobiology of Disease, Vol 37, Iss 1, Pp 67-76 (2010)
It has been extensively reported that diabetes mellitus (DM) patients have a higher risk of developing Alzheimer's disease (AD), but a mechanistic connection between both pathologies has not been provided so far. Carbohydrate-derived advanced glycati
Externí odkaz:
https://doaj.org/article/ed5dbc6172514d10b0c13b854e16f713
Autor:
Aloa Lamarca, Alejandro Gella, Tania Martiañez, Mònica Segura, Joana Figueiro-Silva, Carmen Grijota-Martinez, Ramón Trullas, Núria Casals
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98998 (2014)
In response to peripheral nerve injury, Schwann cells adopt a migratory phenotype and modify the extracellular matrix to make it permissive for cell migration and axonal re-growth. Uridine 5'-triphosphate (UTP) and other nucleotides are released duri
Externí odkaz:
https://doaj.org/article/6bd0ca95eafb47019cf1c1d48946d645
Autor:
Alejandro Gella, Elisenda Sanz, Joaquín Abián, Albert Quintana, Patricia Prada-Dacasa, Melania González-Torres, Montserrat Carrascal
Defects in mitochondrial function lead to severe neuromuscular orphan pathologies known as mitochondrial disease. Among them, Leigh Syndrome is the most common pediatric presentation, characterized by symmetrical brain lesions, hypotonia, motor and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efe46f3f4df5a9dd668e725ef7b842c
Autor:
Alejandro Gella, Patricia Prada-Dacasa, Montserrat Carrascal, Andrea Urpi, Melania González-Torres, Joaquin Abian, Elisenda Sanz, Albert Quintana
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biology
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biology
Defects in mitochondrial function lead to severe neuromuscular orphan pathologies known as mitochondrial disease. Among them, Leigh Syndrome is the most common pediatric presentation, characterized by symmetrical brain lesions, hypotonia, motor and r
Autor:
Guillem Mòdol-Caballero, Pablo Machuca-Márquez, Xavier Navarro, Abel Eraso-Pichot, Alejandro Gella, Fabien Menardy, Angela M. Bard, Irene Bolea, Patricia Prada-Dacasa, Franck Kalume, Albert Quintana, Elisenda Sanz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a7381892c5c18e195c7313f88a418a5
https://doi.org/10.7554/elife.47163.028
https://doi.org/10.7554/elife.47163.028
Autor:
Albert Quintana, Irene Bolea, Elisenda Sanz, Franck Kalume, Alejandro Gella, Fabien Menardy, Angela M. Bard, Pablo Machuca-Márquez, Patricia Prada-Dacasa
Dysfunctions of the mitochondrial energy-generating machinery cause a series of progressive, untreatable and usually fatal diseases collectively known as mitochondrial disease. High energy-requiring organs such as the brain are especially affected, l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52283e65cd8f6f87614caa4a01a351b
https://doi.org/10.1101/556019
https://doi.org/10.1101/556019