Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alejandro Gómez Toledo"'
Autor:
James T. Sorrentino, Gregory J. Golden, Claire Morris, Chelsea D. Painter, Victor Nizet, Alexandre Rosa Campos, Jeffrey W. Smith, Christofer Karlsson, Johan Malmström, Nathan E. Lewis, Jeffrey D. Esko, Alejandro Gómez Toledo
Publikováno v:
mSystems, Vol 7, Iss 4 (2022)
ABSTRACT Vascular dysfunction and organ failure are two distinct, albeit highly interconnected, clinical outcomes linked to morbidity and mortality in human sepsis. The mechanisms driving vascular and parenchymal damage are dynamic and display signif
Externí odkaz:
https://doaj.org/article/7dfffa287d01412680469a2a0ce401c0
Autor:
Gregory J. Golden, Alejandro Gómez Toledo, Alex Marki, James T. Sorrentino, Claire Morris, Raquel J. Riley, Charlotte Spliid, Qiongyu Chen, Ingrid Cornax, Nathan E. Lewis, Nissi Varki, Dzung Le, Johan Malmström, Christofer Karlsson, Klaus Ley, Victor Nizet, Jeffrey D. Esko
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Vascular glycocalyx remodeling is critical to sepsis pathology, but the glycocalyx components that contribute to this process remain poorly characterized. This article shows that during Staphylococcus aureus
Externí odkaz:
https://doaj.org/article/587771f197f24abdb65b991885346424
Autor:
Alejandro Gómez Toledo, Gregory Golden, Alexandre Rosa Campos, Hector Cuello, James Sorrentino, Nathan Lewis, Nissi Varki, Victor Nizet, Jeffrey W. Smith, Jeffrey D. Esko
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Vascular surfaces are rapidly remodeled during systemic inflammatory responses and sepsis. Here, the authors combine in vivo biotinylation and high-resolution mass spectrometry to characterize organ-level changes of the murine vascular cell surface p
Externí odkaz:
https://doaj.org/article/106260de25614125a608d26e65e99791
Autor:
James T. Sorrentino, Gregory J. Golden, Claire Morris, Chelsea Painter, Victor Nizet, Alexandre Rosa Campos, Jeffrey W. Smith, Christofer Karlsson, Johan Malmström, Nathan E. Lewis, Jeffrey D. Esko, Alejandro Gómez Toledo
Vascular dysfunction and organ failure are two distinct, albeit highly interconnected clinical outcomes linked to morbidity and mortality in human sepsis. The mechanisms driving vascular and parenchymal damage are dynamic and display significant mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2658828303f40a828641deb28331413
https://doi.org/10.1101/2021.12.07.471579
https://doi.org/10.1101/2021.12.07.471579
Autor:
Arman Izadi, Yasaman Karami, Eleni Bratanis, Sebastian Wrighton, Hamed Khakzad, Maria Nyblom, Berit Olofsson, Lotta Happonen, Di Tang, Martin Sundwall, Magdalena Godzwon, Yashuan Chao, Alejandro Gomez Toledo, Tobias Schmidt, Mats Ohlin, Michael Nilges, Johan Malmström, Wael Bahnan, Oonagh Shannon, Lars Malmström, Pontus Nordenfelt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the bacterial M prote
Externí odkaz:
https://doaj.org/article/be6b5c313b7e4a23b226edf27ac9fea5
Pathogen-driven degradation of endogenous and therapeutic antibodies during streptococcal infections
Autor:
Alejandro Gomez Toledo, Eleni Bratanis, Erika Velásquez, Sounak Chowdhury, Berit Olofsson, James T. Sorrentino, Christofer Karlsson, Nathan E. Lewis, Jeffrey D. Esko, Mattias Collin, Oonagh Shannon, Johan Malmström
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Group A streptococcus (GAS) is a major bacterial pathogen responsible for both local and systemic infections in humans. The molecular mechanisms that contribute to disease heterogeneity remain poorly understood. Here we show that the transit
Externí odkaz:
https://doaj.org/article/bce37cf8902b4d488654606c706f6c47