Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Alejandro F. Schinder"'
Autor:
Matías Mugnaini, Mariela F. Trinchero, Alejandro F. Schinder, Verónica C. Piatti, Emilio Kropff
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113086- (2023)
Summary: Mammalian hippocampal circuits undergo extensive remodeling through adult neurogenesis. While this process has been widely studied, the specific contribution of adult-born granule cells (aGCs) to spatial operations in the hippocampus remains
Externí odkaz:
https://doaj.org/article/51fb7dfcace64e838b4432e87ac51534
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 202-214.e4 (2020)
Summary: A strong GABAergic tone imposes sparse levels of activity in the dentate gyrus of the hippocampus. This balance is challenged by the addition of new granule cells (GCs) with high excitability. How developing GCs integrate within local inhibi
Externí odkaz:
https://doaj.org/article/ffdf01f2b6dd4800b878f9f95705d65d
Autor:
Mariela F. Trinchero, Karina A. Buttner, Jessica N. Sulkes Cuevas, Silvio G. Temprana, Paula A. Fontanet, M. Cristina Monzón-Salinas, Fernanda Ledda, Gustavo Paratcha, Alejandro F. Schinder
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1129-1139 (2017)
Summary: During aging, the brain undergoes changes that impair cognitive capacity and circuit plasticity, including a marked decrease in production of adult-born hippocampal neurons. It is unclear whether development and integration of those new neur
Externí odkaz:
https://doaj.org/article/7038ccca8ce948268e0b06a8c37ddeb1
Autor:
Victorio Martin Pozo Devoto, Nicolas Dimopoulos, Matías Alloatti, María Belén Pardi, Trinidad M. Saez, María Gabriela Otero, Lucas Eneas Cromberg, Antonia Marín-Burgin, Maria Elida Scassa, Gorazd B. Stokin, Alejandro F. Schinder, Gustavo Sevlever, Tomás Luis Falzone
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The etiology of Parkinson’s disease (PD) converges on a common pathogenic pathway of mitochondrial defects in which α-Synuclein (αSyn) is thought to play a role. However, the mechanisms by which αSyn and its disease-associated allelic v
Externí odkaz:
https://doaj.org/article/ed7ab461035b478bbf2b97dcb519d281
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
The aging brain presents a general decline in plasticity that also affects hippocampal neurogenesis. Besides the well-known reduction in the rate of neuronal generation, development of new neurons is largely delayed in the aging brain. We have recent
Externí odkaz:
https://doaj.org/article/53e3f7f8b1df4e15b550e7d3848b509a
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Synaptic modification in cortical structures underlies the acquisition of novel information that results in learning and memory formation. In the adult dentate gyrus, circuit remodeling is boosted by the generation of new granule cells (GCs) that con
Externí odkaz:
https://doaj.org/article/25ae7dc2c427460dbb1b38ac668c60f3
Publikováno v:
Hippocampus. 33:424-441
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1786f6b38b3b946e3e387dc197d2cbf2
https://doi.org/10.1002/hipo.23505
https://doi.org/10.1002/hipo.23505
Autor:
Matías Mugnaini, Mariela F. Trinchero, Alejandro F. Schinder, Verónica C. Piatti, Emilio Kropff
Mammalian hippocampal circuits undergo extensive remodeling through adult neurogenesis. While this process has been widely studied, the specific contribution of adult-born granule cells (aGCs) to spatial operations in the hippocampus remains unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3731cf051e3f0c76885b84d615aeea57
https://doi.org/10.1101/2022.09.14.507576
https://doi.org/10.1101/2022.09.14.507576
Publikováno v:
Curr Opin Neurobiol
Neurogenesis is a powerful mechanism for structural and functional remodeling that occurs in restricted areas of the adult brain. Although different neurotransmitters regulate various aspects of the progression from neural stem cell quiescence to neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b286998558720343c18b7394a58af06b
https://doi.org/10.1016/j.conb.2021.03.008
https://doi.org/10.1016/j.conb.2021.03.008
Autor:
Mariela F. Trinchero, Gustavo Paratcha, Fernanda Ledda, Pedro Bekinschtein, Antonela Bonafina, Alejandro F. Schinder, Antonella Soledad Ríos
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4308-4319.e4 (2019)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The glial cell line-derived neurotrophic factor (GDNF) is required for the survival and differentiation of diverse neuronal populations during nervous system development. Despite the high expression of GDNF and its receptor GFRα1 in the adult hippoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06f2b62da5a914d068e0bc169af89ae
http://www.sciencedirect.com/science/article/pii/S2211124719316006
http://www.sciencedirect.com/science/article/pii/S2211124719316006