Development of Pharmacological Strategies with Therapeutic Potential in Ischemic Stroke

Autor: Alejandro Escobar-Peso, Emma Martínez-Alonso, Jaime Masjuan, Alberto Alcázar

Publikováno v: Antioxidants, Vol 12, Iss 12, p 2102 (2023)

Acute ischemic stroke constitutes a health challenge with great social impact due to its high incidence, with the social dependency that it generates being an important source of inequality. The lack of treatments serving as effective neuroprotective

Externí odkaz: https://doaj.org/article/89a1b60ff32741968535e80ccfd00415

Preclinical Characterization of Antioxidant Quinolyl Nitrone QN23 as a New Candidate for the Treatment of Ischemic Stroke

Autor: Emma Martínez-Alonso, Alejandro Escobar-Peso, Alicia Aliena-Valero, Germán Torregrosa, Mourad Chioua, Rocío Fernández-Serra, Daniel González-Nieto, Youness Ouahid, Juan B. Salom, Jaime Masjuan, José Marco-Contelles, Alberto Alcázar

Publikováno v: Antioxidants, Vol 11, Iss 6, p 1186 (2022)

Nitrones are encouraging drug candidates for the treatment of oxidative stress-driven diseases such as acute ischemic stroke (AIS). In a previous study, we found a promising quinolylnitrone, QN23, which exerted a neuroprotective effect in neuronal ce

Externí odkaz: https://doaj.org/article/5d0ddac6fefa4f3ebcbbfac8601dd46c

Characterization of a CholesteroNitrone (ISQ-201), a Novel Drug Candidate for the Treatment of Ischemic Stroke

Autor: Emma Martínez-Alonso, Alejandro Escobar-Peso, Maria I. Ayuso, Rafael Gonzalo-Gobernado, Mourad Chioua, Juan J. Montoya, Joan Montaner, Israel Fernández, José Marco-Contelles, Alberto Alcázar

Publikováno v: Antioxidants, Vol 9, Iss 4, p 291 (2020)

Nitrones have a well-recognized capacity as spin-traps and are considered powerful free radical scavengers, which are two important issues in hypoxia-induced oxidative stress and cell death in brain ischemia. Consequently, nitrones have been proposed

Externí odkaz: https://doaj.org/article/c7438302baec4b70b89fab050e8db6f2

Phosphorylation of Eukaryotic Initiation Factor 4G1 (eIF4G1) at Ser1147 Is Specific for eIF4G1 Bound to eIF4E in Delayed Neuronal Death after Ischemia

Autor: Emma Martínez-Alonso, Natalia Guerra-Pérez, Alejandro Escobar-Peso, Lorena Peracho, Rocío Vera-Lechuga, Antonio Cruz-Culebras, Jaime Masjuan, Alberto Alcázar

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 1830, p 1830 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1830
E-Prints Complutense. Archivo Institucional de la UCM
Universitad de Lleida

Ischemic strokes are caused by a reduction in cerebral blood flow and both the ischemic period and subsequent reperfusion induce brain injury, with different tissue damage depending on the severity of the ischemic insult, its duration, and the partic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902a4d6848eb3017ed11b138d254cc39
https://www.mdpi.com/1422-0067/23/3/1830

Privileged Quinolylnitrones for the Combined Therapy of Ischemic Stroke and Alzheimer’s Disease

Autor: Alberto Alcázar, Emma Martínez-Alonso, Isabel Iriepa, Alejandra Palomino-Antolín, Jose M. Alonso, Mourad Chioua, Daniel Diez-Iriepa, Alejandro Escobar-Peso, José Marco-Contelles, Javier Egea

Publikováno v: Pharmaceuticals, Vol 14, Iss 861, p 861 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Pharmaceuticals
Volume 14
Issue 9

Cerebrovascular diseases such as ischemic stroke are known to exacerbate dementia caused by neurodegenerative pathologies such as Alzheimer’s disease (AD). Besides, the increasing number of patients surviving stroke makes it necessary to treat the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa7a97a5bc6f489e0d388ab57ccc43c
https://doi.org/10.3390/ph14090861