High SOX9 maintains glioma stem cell activity through a regulatory loop involving STAT3 and PML

Autor: Paula Aldaz, Natalia Martín-Martín, Ander Saenz-Antoñanzas, Estefania Carrasco-Garcia, María Álvarez-Satta, Alejandro Elúa-Pinin, Steven M. Pollard, Charles H. Lawrie, Manuel Moreno-Valladares, Nicolás Samprón, Jürgen Hench, Robin Lovell-Badge, Arkaitz Carracedo, Ander Matheu

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
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International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 4511

Glioma stem cells (GSCs) are critical targets for glioma therapy. SOX9 is a transcription factor with critical roles during neurodevelopment, particularly within neural stem cells. Previous studies showed that high levels of SOX9 are associated with

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