Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alejandro D Campos"'
Autor:
Petrus R. de Jong, Koji Taniguchi, Alexandra R. Harris, Samuel Bertin, Naoki Takahashi, Jen Duong, Alejandro D. Campos, Garth Powis, Maripat Corr, Michael Karin, Eyal Raz
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
It is unclear how the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathways interact with other signals in intestinal epithelial cells. Here, the authors show that upon loss of Erk1/2, or pharmacological inhibition of MEK1/2, the ERK5 path
Externí odkaz:
https://doaj.org/article/1be108f4d4194c2ab206271625dab19f
Autor:
Betty Lamothe, Yunju Lai, Lana Hur, Natalia Martin Orozco, Jing Wang, Alejandro D Campos, Min Xie, Michael D Schneider, Cynthia R Lockworth, Jared Jakacky, Diep Tran, Michael Ho, Sity Dawud, Chen Dong, Hui-Kuan Lin, Peter Hu, Zeev Estrov, Carlos E Bueso-Ramos, Bryant G Darnay
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51228 (2012)
Previous studies of the conditional ablation of TGF-β activated kinase 1 (TAK1) in mice indicate that TAK1 has an obligatory role in the survival and/or development of hematopoietic stem cells, B cells, T cells, hepatocytes, intestinal epithelial ce
Externí odkaz:
https://doaj.org/article/f98ab889e1f742eb83b60ac8a1485b44
Publikováno v:
Cancer Metastasis Rev
[Image: see text]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71d0a7074b530a9a60fc0ad14b90222
https://doi.org/10.1007/s10555-020-09938-y
https://doi.org/10.1007/s10555-020-09938-y
Autor:
Garth Powis, Michael Karin, Samuel Bertin, Alexandra R. Harris, Alejandro D. Campos, Petrus R. de Jong, Koji Taniguchi, Naoki Takahashi, Jen Duong, Maripat Corr, Eyal Raz
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Nature communications, vol 7, iss 1
Nature Communications
Nature communications, vol 7, iss 1
Nature Communications
The ERK1/2 MAPK signalling module integrates extracellular cues that induce proliferation and differentiation of epithelial lineages, and is an established oncogenic driver, particularly in the intestine. However, the interrelation of the ERK1/2 modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf22ca4dcddb21d05c98e18418a6def
https://doaj.org/article/1be108f4d4194c2ab206271625dab19f
https://doaj.org/article/1be108f4d4194c2ab206271625dab19f
Autor:
Robert Lemos, Marco Maruggi, Brian P. James, Petrus R. de Jong, David Scott, J. Pablo Arnoletti, Garth Powis, Alejandro D. Campos, Morgan A. Brand, Sally A. Litherland
Publikováno v:
Cancer Research. 78:2916-2916
Patients with pancreatic ductal adenocarcinoma (PDAC) have a poor prognosis, and more effective systemic treatments for patients with local progression or metastasis (85% of cases) are needed. The pancreatic tumor microenvironment provides a rich sou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d1b4604b7719011b997cd4bb8cd5a38
https://doi.org/10.1158/1538-7445.am2018-2916
https://doi.org/10.1158/1538-7445.am2018-2916
Autor:
Anagha Srirangam, Malene Hansen, J. Pablo Arnoletti, Claudia P. Miller, Brian P. James, Morgan A. Brand, Sean-Luc Shanahan, Ally Perlina, Petrus R. de Jong, Nikolas Marino, Randall French, Adam D. Richardson, Olga Zagnitko, Alejandro D. Campos, Garth Powis, Andrew Hodges, Andrew M. Lowy, Alexey M. Eroshin, Sally A. Litherland, David Scott
Publikováno v:
Cancer Research. 77:2967-2967
Pancreatic ductal adenocarcinoma (PDAC) is non-resectable in the majority of patients and highly resistant to chemotherapy, resulting in a poor survival. The tumor microenvironment and hypoxia are important modifiers of cancer progression in PDAC. Un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fcf666530067e7819a953035c2b3e3c
https://doi.org/10.1158/1538-7445.am2017-2967
https://doi.org/10.1158/1538-7445.am2017-2967
Autor:
Ching Yuan Wu, Juan Wu, Szu Wei Lee, Alejandro D. Campos, Bryant G. Darnay, Jing Wang, Xian Zhang, Yun Seong Jeong, Chia Hsin Chan, Hong-Yo Kang, Betty Lamothe, Wei Lei Yang, Hui Kuan Lin
Publikováno v:
Journal of Biological Chemistry. 286:30806-30815
DNA damage response is an important surveillance mechanism used to maintain the integrity of the human genome in response to genotoxic stress. Histone variant H2AX is a critical sensor that undergoes phosphorylation at serine 139 upon genotoxic stres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0251e2285e5158ec24ded554371d2111
https://doi.org/10.1074/jbc.m111.257469
https://doi.org/10.1074/jbc.m111.257469
Autor:
Xin Lin, Szu Wei Lee, Jing Wang, Hui Kuan Lin, Wei Lei Yang, Chia Hsin Chan, Betty Lamothe, Alejandro D. Campos, Brian C. Grabiner, Lana Hur, Bryant G. Darnay
Publikováno v:
Science. 325:1134-1138
Regulating Akt The protein kinase Akt is activated in response to receptor-activated generation of the signaling second messenger phosphatidylinositol 3,4,5-trisphosphate and has roles in regulation of diverse processes from metabolism and cell survi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d25dc901a9bf48e998be206e203fdde
https://doi.org/10.1126/science.1175065
https://doi.org/10.1126/science.1175065
Autor:
Bryant G. Darnay, Betty Lamothe, William K. Webster, Alejandro D. Campos, Ambily Gopinathan, Lana Hur
Publikováno v:
Journal of Biological Chemistry. 283:24871-24880
TRAF6, a crucial adaptor molecule in innate and adaptive immunity, contains three distinct functional domains. The C-terminal TRAF domain facilitates oligomerization and sequence-specific interaction with receptors or other adaptor proteins. In conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2666dede5dec3cf08bc6bfbdcbd2c5
https://doi.org/10.1074/jbc.m802749200
https://doi.org/10.1074/jbc.m802749200
Autor:
Arnaud Besse, Bryant G. Darnay, William K. Webster, Alejandro D. Campos, Su Chang Lin, Hao Wu, Betty Lamothe, Upendra Maddineni
Publikováno v:
Journal of Biological Chemistry. 282:3918-3928
Transforming growth factor beta-activated kinase 1 (TAK1), a member of the MAPKKK family, was initially described to play an essential role in the transforming growth factor beta-signaling pathway, but recent evidence has emerged implicating TAK1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3a7d9263edba0a48cf51497d6fc90c
https://doi.org/10.1074/jbc.m608867200
https://doi.org/10.1074/jbc.m608867200