Sporothrix brasiliensis: A Review of an Emerging South American Fungal Pathogen, Its Related Disease, Presentation and Spread in Argentina

Autor: Alejandro Etchecopaz, María A. Toscanini, Amelia Gisbert, Javier Mas, Miguel Scarpa, Cristina A. Iovannitti, Karla Bendezú, Alejandro D. Nusblat, Ricardo Iachini, María L. Cuestas

Publikováno v: Journal of Fungi, Vol 7, Iss 3, p 170 (2021)

Sporotrichosis, caused by Sporothrix schenckii and related species, is the most frequent implantation mycosis in Latin America. In Argentina, over the last 8 years, there have been 0.16 new cases per month of feline sporotrichosis in 2011, increasing

Externí odkaz: https://doaj.org/article/b9e1a6de670e451a8aceb0ccbbcbceb2

Diagnosis of histoplasmosis: current status and perspectives

Autor: Alejandro D. Nusblat, María Agustina Toscanini, María Luján Cuestas

Publikováno v: Applied Microbiology and Biotechnology. 105:1837-1859

Histoplasmosis is a worldwide-distributed systemic mycosis caused by the dimorphic fungus Histoplasma capsulatum. Its clinical manifestations range from subclinical or mild respiratory illness to progressive disseminated histoplasmosis (PDH), a life-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b13de40936520d8d875be1b990dcfa
https://doi.org/10.1007/s00253-021-11170-9

A novel Tetrahymena thermophila sterol C-22 desaturase belongs to the fatty acid hydroxylase/desaturase superfamily

Autor: María L. Sanchez Granel, Nicolás G. Siburu, Annamária Fricska, Lucas L. Maldonado, Laura B. Gargiulo, Clara B. Nudel, Antonio D. Uttaro, Alejandro D. Nusblat

Publikováno v: Journal of Biological Chemistry. 298:102397

Sterols in eukaryotic cells play important roles in modulating membrane fluidity and in cell signaling and trafficking. During evolution, a combination of gene losses and acquisitions gave rise to an extraordinary diversity of sterols in different or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b052a1438e17e217f797fb0a0c9d8f0b
https://doi.org/10.1016/j.jbc.2022.102397

Histoplasma capsulatum 100-kilodalton antigen: recombinant production, characterization, and evaluation of its possible application in the diagnosis of histoplasmosis

Autor: María A, Toscanini, Daniel González, Maglio, Paula, Capece, Gladys, Posse, Cristina A, Iovannitti, Alejandro D, Nusblat, María L, Cuestas

Publikováno v: Applied microbiology and biotechnology. 104(13)

The goal of the present work was to develop a novel reagent with potential for histoplasmosis diagnosis. For this purpose, the genetic sequence of the 100 kDa protein of Histoplasma capsulatum (Hcp100) was cloned and expressed as a secretory protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::778eacc3e76315dd88fa0062c27b444c
https://pubmed.ncbi.nlm.nih.gov/32377899

Genome-wide Transcriptional Analysis of Tetrahymena thermophila Response to Exogenous Cholesterol

Autor: Nicolás García Siburu, Claudio H. Slamovits, Alejandro D. Nusblat, Sebastián R. Najle, Eduard Ocaña-Pallarès, Clara B. Nudel, Antonio D. Uttaro, Josefina Hernández

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Digital.CSIC. Repositorio Institucional del CSIC
instname

The ciliate Tetrahymena thermophila does not require sterols for growth and synthesizes pentacyclic triterpenoid alcohols, mainly tetrahymanol, as sterol surrogates. However, when sterols are present in the environment, T. thermophila efficiently inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d8324ffbc4cfced1ad2d115ae8235e
https://pubmed.ncbi.nlm.nih.gov/31705733