Výsledky vyhledávání - "Alejandro Carrillo-Jimenez"

Akademický článek

Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation

Autor: Alejandro Carrillo-Jimenez, Mar Puigdellívol, Anna Vilalta, Jose Luis Venero, Guy Charles Brown, Peter StGeorge-Hyslop, Miguel Angel Burguillos

Publikováno v: Frontiers in Cellular Neuroscience, Vol 12 (2018)

Microglia, the resident immune cells of the brain, have multiple functions in physiological and pathological conditions, including Alzheimer’s disease (AD). The use of primary microglial cell cultures has proved to be a valuable tool to study micro

Externí odkaz: https://doaj.org/article/449fed1809fe4879bc27d4e932858aef

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Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon

Autor: Isabel María Alonso-Bellido, José L. Venero, Marti Santiago, Melania Gonzalez-Rodriguez, Alejandro Carrillo-Jimenez, Juan García-Revilla, Manuel Felices-Navarro, María D. Vázquez-Carretero, Rocío M. de Pablos, María Angustias Roca-Ceballos, Ana E. Carvajal, Irene García-Domínguez, Pablo García-Miranda, Ana M. Espinosa-Oliva, M.J. Peral, Arturo Temblador

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Frontiers in Pharmacology

Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the knowledge of risk factors as well as the development of new putative molecular targets is mandatory. In this sense, peripheral infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ca482d5d8ab8c927ef6b97636d3d61
http://hdl.handle.net/10261/262823

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TET2 regulates the neuroinflammatory response in microglia

Publikováno v: Cell Reports
Cell Reports, Vol 29, Iss 3, Pp 697-713.e8 (2019)
713.e8
idUS. Depósito de Investigación de la Universidad de Sevilla
instname

Summary: Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for microglia in neuroinflammation and neurodegeneration, little is known about their epigenomic regulation of the inflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c3f67412a8bbd92c7a1a55a83f2a98
https://doi.org/10.1101/592055

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Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Immunology, 17(11), 1282-1290. Nature Publishing Group

Glioma cells recruit and exploit microglia (the resident immune cells of the brain) for their proliferation and invasion ability. The underlying molecular mechanism used by glioma cells to transform microglia into a tumor-supporting phenotype has rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836c02382d1473951eba69ac60d9ff37
https://doi.org/10.1038/ni.3545

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Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease

Autor: María Angustias Roca-Ceballos, Karolina Veselá, Irene García-Domínguez, Juan García-Revilla, Alejandro Carrillo-Jimenez, José L. Venero, Marti Santiago, Rocío M. de Pablos

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Frontiers in Cellular Neuroscience

The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson’s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa976afd0490da1e9019339ac18cbd8
http://hdl.handle.net/10261/180489

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Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration

Autor: John V. Priestley, José L. Venero, Tomas Deierborg, Paul King, Ping K. Yip, Chi Cheng Chau, Ashray Jayaram Shetty, Alexander Michael Scott Egerton, Jordi L. Tremoleda, Guy C. Brown, Miguel Angel Burguillos, Meirion Davies, Alejandro Carrillo-Jimenez, Zhuo Hao Liu, Anna Vilalta, Adina T. Michael-Titus, Koji Nomura

Publikováno v: Scientific Reports
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC

Traumatic brain injury (TBI) is currently a major cause of morbidity and poor quality of life in Western society, with an estimate of 2.5 million people affected per year in Europe, indicating the need for advances in TBI treatment. Within the first

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218308d426e14af171e9e99a581eea31
https://pubmed.ncbi.nlm.nih.gov/28128358

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Caspase-8 inhibition represses initial human monocyte activation in septic shock model

Autor: Johanna Rodhe, José Antonio Pérez-Simón, Teresa Caballero-Velázquez, Luis Ignacio Sánchez-Abarca, Antonio J. Herrera, José L. Venero, Alejandro Carrillo-Jimenez, P Vlachos, Maria Jose Oliva-Martin, Bertrand Joseph, Albert García-Quintanilla

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
Oncotarget

In septic patients, the onset of septic shock occurs due to the over-activation of monocytes. We tested the therapeutic potential of directly targeting innate immune cell activation to limit the cytokine storm and downstream phases. We initially inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfeb3cd8b324c678efd39715b768438b
https://idus.us.es/xmlui/handle/11441/54656

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Evaluation of a method for murine monocyte isolation by bone marrow depletion

Autor: Luis Ignacio Sánchez-Abarca, José A. Pérez-Simón, Alejandro Carrillo-Jimenez, Maria Jose Oliva-Martin, José L. Venero

Publikováno v: Analytical biochemistry. 480

The study of monocyte activation and differentiation has great applications in sepsis, chronic inflammatory diseases, and cancer studies. However, despite the existence of well-established protocols for monocyte purification from human blood, the iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527d915f65ffaa60434ce6d7dd77f0c6
https://pubmed.ncbi.nlm.nih.gov/25892220

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Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model

Autor: Johanna Rodhe, José L. Venero, Alejandro Carrillo-Jimenez, Martiniano Santiago, Maria Jose Oliva-Martin, Edel Kavanagh, Bertrand Joseph, Miguel Angel Burguillos

Publikováno v: Aging (Albany NY)
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Karolinska Institutet
Scopus-Elsevier

Increasing evidence involves sustained pro-inflammatory microglia activation in the pathogenesis of different neurodegenerative diseases, particularly Parkinson's disease (PD). We recently uncovered a completely novel and unexpected role for caspase-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf4e4ee1a85fe98ebda1b304d1c802a
https://idus.us.es/xmlui/handle/11441/54639

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