Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Alejandro B. Balazs"'
Autor:
Stefan Gravenstein, Frank DeVone, Oladayo A. Oyebanji, Yasin Abul, Yi Cao, Philip A. Chan, Christopher W. Halladay, James L. Rudolph, Clare Nugent, Jürgen Bosch, Christopher L. King, Brigid M. Wilson, Alejandro B. Balazs, Elizabeth M. White, David H. Canaday, Kevin W. McConeghy
Publikováno v:
EBioMedicine, Vol 105, Iss , Pp 105180- (2024)
Summary: Background: Bivalent SARS-CoV-2 vaccines were developed to counter increasing susceptibility to emerging SARS-CoV-2 variants. We evaluated the durability of immunity and protection following first bivalent vaccination among nursing home resi
Externí odkaz:
https://doaj.org/article/c66c2eab90a649b9b371a9c9c296146e
Autor:
Eike-Christian Wamhoff, Larance Ronsard, Jared Feldman, Grant A. Knappe, Blake M. Hauser, Anna Romanov, James Brett Case, Shilpa Sanapala, Evan C. Lam, Kerri J. St. Denis, Julie Boucau, Amy K. Barczak, Alejandro B. Balazs, Michael S. Diamond, Aaron G. Schmidt, Daniel Lingwood, Mark Bathe
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize antigens and enhance humoral immunity through multivalent antigen display. However, P-VLPs are thymus-dependent antigens that are themselves immunogenic and
Externí odkaz:
https://doaj.org/article/a903d94958bc48e7ac6e79ace0aa2f9a
Autor:
Nicolas M. S. Galvez, Maegan L. Sheehan, Allen Z. Lin, Yi Cao, Evan C. Lam, Abigail M. Jackson, Alejandro B. Balazs
Publikováno v:
Viruses, Vol 16, Iss 8, p 1320 (2024)
Quantifying viral growth rates is key to understanding evolutionary dynamics and the potential for mutants to escape antiviral drugs. Defining evolutionary escape paths and their impact on viral fitness allows for the development of drugs that are re
Externí odkaz:
https://doaj.org/article/c07ea1bf5e9d451c9fe8f2ce722923a4
Autor:
Yannic C. Bartsch, Jessica W. Chen, Jaewon Kang, Madeleine D. Burns, Kerri J. St Denis, Maegan L. Sheehan, Jameson P. Davis, Andrea G. Edlow, Alejandro B. Balazs, Lael M. Yonker, Galit Alter
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-10 (2022)
Abstract Currently available mRNA vaccines are extremely safe and effective to prevent severe SARS-CoV-2 infections. However, the emergence of variants of concerns (VOCs) has highlighted the importance of high population-based vaccine rates to effect
Externí odkaz:
https://doaj.org/article/3c683d6a00f5452bbe48e6ed7480869d
Autor:
Caroline G. Atyeo, Lydia L. Shook, Sara Brigida, Rose M. De Guzman, Stepan Demidkin, Cordelia Muir, Babatunde Akinwunmi, Arantxa Medina Baez, Maegan L. Sheehan, Erin McSweeney, Madeleine D. Burns, Ruhi Nayak, Maya K. Kumar, Chinmay D. Patel, Allison Fialkowski, Dana Cvrk, Ilona T. Goldfarb, Lael M. Yonker, Alessio Fasano, Alejandro B. Balazs, Michal A. Elovitz, Kathryn J. Gray, Galit Alter, Andrea G. Edlow
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Pregnant individuals infected with SARS-CoV-2 are at high risk of morbidity and mortality, in addition to adverse pregnancy outcomes, yet little is known regarding trimester-specific immunity and maternal protection from COVID-19 vaccine platforms. A
Externí odkaz:
https://doaj.org/article/66b4b218faf745078c631fe6abe0837e
Autor:
Kim Vanuytsel, Carlos Villacorta-Martin, Jonathan Lindstrom-Vautrin, Zhe Wang, Wilfredo F. Garcia-Beltran, Vladimir Vrbanac, Dylan Parsons, Evan C. Lam, Taylor M. Matte, Todd W. Dowrey, Sara S. Kumar, Mengze Li, Feiya Wang, Anthony K. Yeung, Gustavo Mostoslavsky, Ruben Dries, Joshua D. Campbell, Anna C. Belkina, Alejandro B. Balazs, George J. Murphy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
During human embryonic development, haematopoietic stem cells of the foetal liver undergo expansion, while retaining engraftment capacity. Here the authors apply CITE-seq to profile single cells from a human foetal liver, identifying a molecular sign
Externí odkaz:
https://doaj.org/article/cac11a57fa10405ca22f6fddb6df2365
Autor:
Blake M. Hauser, Maya Sangesland, Evan C. Lam, Jared Feldman, Alejandro B. Balazs, Daniel Lingwood, Aaron G. Schmidt
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Since the emergence of SARS-CoV-2 (SARS-2), multiple vaccine candidates were developed and studied both preclinically and clinically. Nearly all are based on the SARS-2 spike glycoprotein or its receptor binding domain (RBD). Studies of these vaccine
Externí odkaz:
https://doaj.org/article/202117d6ed6545219d53d114e64199c2
Autor:
David H. Canaday, Oladayo A. Oyebanji, Elizabeth White, Debbie Keresztesy, Michael Payne, Dennis Wilk, Lenore Carias, Htin Aung, Kerri St. Denis, Maegan L. Sheehan, Sarah D. Berry, Cheryl M. Cameron, Mark J. Cameron, Brigid M. Wilson, Alejandro B. Balazs, Christopher L. King, Stefan Gravenstein
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104066- (2022)
Summary: Background: Nursing home (NH) residents have borne a disproportionate share of SARS-CoV-2 morbidity and mortality. Vaccines have limited hospitalisation and death from earlier variants in this vulnerable population. With the rise of Omicron
Externí odkaz:
https://doaj.org/article/e0efcd7e5c234387bcaeaaa2a9f31c49
Autor:
Abigail E. Schiff, Alice H. Linder, Shillah N. Luhembo, Stephanie Banning, Martin J. Deymier, Thomas J. Diefenbach, Amy K. Dickey, Athe M. Tsibris, Alejandro B. Balazs, Josalyn L. Cho, Benjamin D. Medoff, Gerhard Walzl, Robert J. Wilkinson, Wendy A. Burgers, Björn Corleis, Douglas S. Kwon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Alveolar macrophages (AMs) are critical for defense against airborne pathogens and AM dysfunction is thought to contribute to the increased burden of pulmonary infections observed in individuals living with HIV-1 (HIV). While HIV nucleic aci
Externí odkaz:
https://doaj.org/article/0c180a3a227b47598d0db0a78f5b3e8a
Autor:
Blake M. Hauser, Maya Sangesland, Kerri J. St. Denis, Evan C. Lam, James Brett Case, Ian W. Windsor, Jared Feldman, Timothy M. Caradonna, Ty Kannegieter, Michael S. Diamond, Alejandro B. Balazs, Daniel Lingwood, Aaron G. Schmidt
Publikováno v:
Cell Reports, Vol 38, Iss 12, Pp 110561- (2022)
Summary: Eliciting antibodies to surface-exposed viral glycoproteins can generate protective responses that control and prevent future infections. Targeting conserved sites may reduce the likelihood of viral escape and limit the spread of related vir
Externí odkaz:
https://doaj.org/article/9af234df3f1549f583881a398111b526