Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Alejandro A Pezzulo"'
Autor:
Emma M Stapleton, Kathy Keck, Robert Windisch, Mallory R Stroik, Andrew L Thurman, Joseph Zabner, Ian M Thornell, Alejandro A Pezzulo, Julia Klesney-Tait, Alejandro P Comellas
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0269647 (2022)
IntroductionVitamin D supplementation has been suggested to enhance immunity during respiratory infection season. We tested the effect of active vitamin D (calcitriol) supplementation on key airway innate immune mechanisms in vitro.MethodsPrimary hum
Externí odkaz:
https://doaj.org/article/8ada10e21bdc48dc801696506f27cec3
Measles virus exits human airway epithelia within dislodged metabolically active infectious centers.
Autor:
Camilla E Hippee, Brajesh K Singh, Andrew L Thurman, Ashley L Cooney, Alejandro A Pezzulo, Roberto Cattaneo, Patrick L Sinn
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009458 (2021)
Measles virus (MeV) is the most contagious human virus. Unlike most respiratory viruses, MeV does not directly infect epithelial cells upon entry in a new host. MeV traverses the epithelium within immune cells that carry it to lymphatic organs where
Externí odkaz:
https://doaj.org/article/14e02861722249fbadcfe8765f2c24eb
Autor:
Jennifer A Borcherding, Haihan Chen, Juan C Caraballo, Jonas Baltrusaitis, Alejandro A Pezzulo, Joseph Zabner, Vicki H Grassian, Alejandro P Comellas
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57673 (2013)
Air pollution is a risk factor for respiratory infections, and one of its main components is particulate matter (PM), which is comprised of a number of particles that contain iron, such as coal fly ash (CFA). Since free iron concentrations are extrem
Externí odkaz:
https://doaj.org/article/81ba977403e542368a78ccba3e4bf447
Autor:
Alejandro A Pezzulo, Emma E Hornick, Michael V Rector, Miriam Estin, Anna C Reisetter, Peter J Taft, Stephen C Butcher, A Brent Carter, J Robert Manak, David A Stoltz, Joseph Zabner
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43777 (2012)
Paraoxonases (PON) are a family of proteins (PON1, 2 and 3) with multiple enzymatic activities. PON1 interferes with homoserine lactone-mediated quorum sensing in bacteria and with reactive oxygen species (ROS) in humans and mice. PON1 gene mutations
Externí odkaz:
https://doaj.org/article/cef0308d5eca4bdf8db408f320867777
Autor:
Patrick L Sinn, Ashley L Cooney, Mayumi Oakland, Douglas E Dylla, Tanner J Wallen, Alejandro A Pezzulo, Eugene H Chang, Paul B McCray, Jr
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
In this study, we investigated lentiviral vector development and transduction efficiencies in well-differentiated primary cultures of pig airway epithelia (PAE) and wild-type pigs in vivo. We noted gene transfer efficiencies similar to that observed
Externí odkaz:
https://doaj.org/article/840c84be090f410a913c5655507d463c
Autor:
Alejandro A Pezzulo, Jeydith Gutiérrez, Kelly S Duschner, Kelly S McConnell, Peter J Taft, Sarah E Ernst, Timothy L Yahr, Kamal Rahmouni, Julia Klesney-Tait, David A Stoltz, Joseph Zabner
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16166 (2011)
Diabetes mellitus predisposes the host to bacterial infections. Moreover, hyperglycemia has been shown to be an independent risk factor for respiratory infections. The luminal surface of airway epithelia is covered by a thin layer of airway surface l
Externí odkaz:
https://doaj.org/article/77ba19f96d4940e2b9207b54926d980c
Autor:
Camilo Cano Portillo, Raul Villacreses, Andrew L. Thurman, Alejandro A. Pezzulo, Joseph Zabner, Ian M. Thornell
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C1044-C1051
Na/K ATPase activity is essential for ion transport across epithelia. FXYD3, a γ subunit of the Na/K ATPase, is expressed in the airway, but its function remains undetermined. Single-cell RNA sequencing and immunohistochemistry revealed that FXYD3 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c490d504200d1c5db0038017dbea1744
https://doi.org/10.1152/ajpcell.00047.2022
https://doi.org/10.1152/ajpcell.00047.2022
Autor:
Tayyab Rehman, Philip H. Karp, Andrew L. Thurman, Steven E. Mather, Akansha Jain, Ashley L. Cooney, Patrick L. Sinn, Alejandro A. Pezzulo, Michael E. Duffey, Michael J. Welsh
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:491-502
In cystic fibrosis (CF), reduced HCOsub3/subsup-/supsecretion acidifies the airway surface liquid (ASL), and the acidic pH disrupts host defenses. Thus, understanding the control of ASL pH (pHsubASL/sub) in CF may help identify novel targets and faci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8b1f9bffca58e51ad561baf9bb5a3b
https://doi.org/10.1165/rcmb.2022-0172oc
https://doi.org/10.1165/rcmb.2022-0172oc
Autor:
Josalyn L. Cho, Raul Villacreses, Prashant Nagpal, Junfeng Guo, Alejandro A. Pezzulo, Andrew L. Thurman, Nabeel Y. Hamzeh, Robert J. Blount, Spyridon Fortis, Eric A. Hoffman, Joseph Zabner, Alejandro P. Comellas
Publikováno v:
Radiology. 304:185-192
Background The long-term effects of SARS-CoV-2 infection on pulmonary structure and function remain incompletely characterized. Purpose To test whether SARS-CoV-2 infection leads to small airways disease in patients with persistent symptoms. Material
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1e3581da48f078857905f0e85d4e63
https://doi.org/10.1148/radiol.212170
https://doi.org/10.1148/radiol.212170
Autor:
Andrew L. Thurman, Xiaopeng Li, Raul Villacreses, Wenjie Yu, Huiyu Gong, Steven E. Mather, Guillermo S. Romano-Ibarra, David K. Meyerholz, David A. Stoltz, Michael J. Welsh, Ian M. Thornell, Joseph Zabner, Alejandro A. Pezzulo
Publikováno v:
American journal of respiratory cell and molecular biology. 66(6)
Lack of CFTR (cystic fibrosis transmembrane conductance regulator) affects the transcriptome, composition, and function of large and small airway epithelia in people with advanced cystic fibrosis (CF); however, whether lack of CFTR causes cell-intrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc3ff6fb1e5a08d17861be6e46f3300
https://pubmed.ncbi.nlm.nih.gov/35294854
https://pubmed.ncbi.nlm.nih.gov/35294854