Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alejandro Álvarez-Quilón"'
Autor:
Alejandro Álvarez-Quilón, José Terrón-Bautista, Irene Delgado-Sainz, Almudena Serrano-Benítez, Rocío Romero-Granados, Pedro Manuel Martínez-García, Silvia Jimeno-González, Cristina Bernal-Lozano, Cristina Quintero, Lourdes García-Quintanilla, Felipe Cortés-Ledesma
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The ATM kinase is a key regulator of the DNA damage response to double-strand breaks (DSBs) and its homozygous loss in patients predisposes to lymphoid malignancies. Here, the authors develop a Tdp2 −/− Atm −/− double-deficient mouse model to
Externí odkaz:
https://doaj.org/article/9f1676662817487ea864a82ec0a5a86d
Autor:
Nicole Hustedt, Alejandro Álvarez-Quilón, Andrea McEwan, Jing Yi Yuan, Tiffany Cho, Lisa Koob, Traver Hart, Daniel Durocher
Publikováno v:
Open Biology, Vol 9, Iss 9 (2019)
The response to DNA replication stress in eukaryotes is under the control of the ataxia–telangiectasia and Rad3-related (ATR) kinase. ATR responds to single-stranded (ss) DNA to stabilize distressed DNA replication forks, modulate DNA replication f
Externí odkaz:
https://doaj.org/article/de50d630a77649aab35abfdcf2bf902d
Autor:
Pierre Caron, Jonathan Choudjaye, Thomas Clouaire, Béatrix Bugler, Virginie Daburon, Marion Aguirrebengoa, Thomas Mangeat, Jason S. Iacovoni, Alejandro Álvarez-Quilón, Felipe Cortés-Ledesma, Gaëlle Legube
Publikováno v:
Cell Reports, Vol 13, Iss 8, Pp 1598-1609 (2015)
DNA double-strand breaks (DSBs) elicit the so-called DNA damage response (DDR), largely relying on ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PKcs), two members of the PI3K-like kinase family, whose respective functions
Externí odkaz:
https://doaj.org/article/ade3514d2cc9404f8b5668e7ba76674c
Autor:
David Gallo, Jordan T. F. Young, Jimmy Fourtounis, Giovanni Martino, Alejandro Álvarez-Quilón, Cynthia Bernier, Nicole M. Duffy, Robert Papp, Anne Roulston, Rino Stocco, Janek Szychowski, Artur Veloso, Hunain Alam, Prasamit S. Baruah, Alexanne Bonneau Fortin, Julian Bowlan, Natasha Chaudhary, Jessica Desjardins, Evelyne Dietrich, Sara Fournier, Chloe Fugère-Desjardins, Theo Goullet de Rugy, Marie-Eve Leclaire, Bingcan Liu, Vivek Bhaskaran, Yael Mamane, Henrique Melo, Olivier Nicolas, Akul Singhania, Rachel K. Szilard, Ján Tkáč, Shou Yun Yin, Stephen J. Morris, Michael Zinda, C. Gary Marshall, Daniel Durocher
Publikováno v:
Nature. 604:749-756
Amplification of the CCNE1 locus on chromosome 19q12 is prevalent in multiple tumour types, particularly in high-grade serous ovarian cancer, uterine tumours and gastro-oesophageal cancers, where high cyclin E levels are associated with genome instab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc789be54b458503be76fad03b732048
https://doi.org/10.1038/s41586-022-04638-9
https://doi.org/10.1038/s41586-022-04638-9
Autor:
Jessica A. Stewart, Javier M. Di Noia, Amy Hin Yan Tong, Diana Nakib, Maribel Berru, Alberto Martin, Katherine Chan, Noé Seija Desivo, Gholam Ali Kardar, James R. Carlyle, Daniel Durocher, Rukshana Mohamad-Ramshan, Yuqing Feng, Jason Moffat, Madusha L. W. Perera, Rossanna C. Pezo, Alejandro Álvarez-Quilón, Philip Barbulescu, Ashok S. Bhagwat, Gavin Li, Conglei Li
Publikováno v:
Nature
Activation-induced cytidine deaminase (AID) catalyses the deamination of deoxycytidines to deoxyuracils within immunoglobulin genes to induce somatic hypermutation and class-switch recombination1,2. AID-generated deoxyuracils are recognized and proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9900ef9c698a316ab01d156a02d6c7
https://doi.org/10.1038/s41586-021-04144-4
https://doi.org/10.1038/s41586-021-04144-4
Autor:
Nicole Hustedt, Henrique Melo, Dheva Setiaputra, Jessica Desjardins, Artur Veloso, Rachel K. Szilard, Shou Yun Yin, Alejandro Álvarez-Quilón, Michael Zinda, Timothy F. Ng, Meagan Munro, Robert Papp, Daniel Durocher, Mara De Marco Zompit, Yibo Xue, Giovanni Martino, Jordan T.F. Young, Nathalie Moatti, Salomé Adam, Natasha Chaudhary, Vivek Bhaskaran, Manuel Stucki, Sylvie M. Noordermeer, Toshiro K. Ohsumi, Silvia Emma Rossi
Publikováno v:
Nature Cancer, 2(12), 1357-+. NATURE PORTFOLIO
BRCA1/2-mutated cancer cells adapt to the genome instability caused by their deficiency in homologous recombination (HR). Identification of these adaptive mechanisms may provide therapeutic strategies to target tumors caused by the loss of these gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9275bd317b6ceebb275c11ab3f1a0320
https://doi.org/10.5167/uzh-216678
https://doi.org/10.5167/uzh-216678
Autor:
Yuichiro Saito, Masato T. Kanemaki, Yichao Zhao, Michele Olivieri, Dheva Setiaputra, Salomé Adam, Andrea Jurisicova, Jing Yi Yuan, Daniel Durocher, Michal Zimmermann, Nicole Hustedt, Andrea McEwan, Alejandro Álvarez-Quilón
Publikováno v:
Genes & Development. 33:1397-1415
DNA repair by homologous recombination (HR) is essential for genomic integrity, tumor suppression, and the formation of gametes. HR uses DNA synthesis to repair lesions such as DNA double-strand breaks and stalled DNA replication forks, but despite h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b2a0db3611e8b4b54b9b32ffac9e28
https://doi.org/10.1101/gad.329508.119
https://doi.org/10.1101/gad.329508.119
Autor:
Yin Sy, Szychowski J, Natasha Chaudhary, Duffy Nm, Veloso A, Bowlan J, Stocco R, Papp R, Martino G, Singhania A, Rachel K. Szilard, Fourtounis J, Leclaire M, Liu B, Alejandro Álvarez-Quilón, de Rugy Tg, Nicolas O, Henrique Melo, Baruah Ps, Hunain Alam, Gary Marshall C, Young Jt, Dietrich E, Gallo D, Desjardins J, Bernier C, Fugère-Desjardins C, Tkáč J, Fournier S, Michael Zinda, Roulston A, Morris Sj, Fortin Ab, Daniel Durocher
Amplification of the gene encoding cyclin E (CCNE1) is an oncogenic driver in several malignancies and is associated with chemoresistance and poor prognosis. To uncover therapeutic targets forCCNE1-amplified tumors, we undertook genome-scale CRISPR/C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::994c0ffdc16dbed0d63dc664ac49d980
https://doi.org/10.1101/2021.04.08.438361
https://doi.org/10.1101/2021.04.08.438361
Autor:
Silvia Emma Rossi, Henrique Melo, Michael Zinda, Veloso A, Bhaskaran, Desjardins J, Zompit Mdm, Timothy F. Ng, Papp R, Salomé Adam, Daniel Durocher, Nathalie Moatti, Alejandro Álvarez-Quilón, Sylvie M. Noordermeer, Meagan Munro, Yin Sy, Young Jt, Nicole Hustedt, Natasha Chaudhary, Rachel K. Szilard, Dheva Setiaputra, Martino G, Manuel Stucki, Ohsumi Tk
BRCA1/2-mutated cancer cells must adapt to the genome instability caused by their deficiency in homologous recombination. Identifying and targeting these adaptive mechanisms may provide new therapeutic strategies. Here we present the results of genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74faea63b60db263e7506b7972da4eb1
https://doi.org/10.1101/2021.02.08.430060
https://doi.org/10.1101/2021.02.08.430060
Autor:
Katherine Chan, Noé Seija Desivo, James R. Carlyle, Rukshana Mohamad-Ramshan, Diana Nakib, Gavin Li, Alejandro Álvarez-Quilón, Daniel Durocher, Jessica A. Stewart, Conglei Li, Maribel Berru, Philip Barbulescu, Yuqing Feng, Rossanna C. Pezo, Javier M. Di Noia, Alberto Martin, Jason Moffat, Amy Hin Yan Tong, Gholam Ali Kardar, Ashok S. Bhagwat, Madusha L. W. Perera
Activation-induced cytidine deaminase (AID) catalyzes the deamination of deoxycytidines within Immunoglobulin (Ig) genes to induce somatic hypermutation (SHM) and class switch recombination (CSR) 1,2. AID-induced deoxyuracils within Ig loci are recog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a520bdfde1aa03ae4738011fcb5745b
https://doi.org/10.1101/2020.12.23.423975
https://doi.org/10.1101/2020.12.23.423975