Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Alejandro, Martin Montalvo"'
Autor:
Aina Lluch, Jessica Latorre, Angela Serena-Maione, Isabel Espadas, Estefanía Caballano-Infantes, José M. Moreno-Navarrete, Núria Oliveras-Cañellas, Wifredo Ricart, María M. Malagón, Alejandro Martin-Montalvo, Walter Birchmeier, Witold Szymanski, Johannes Graumann, María Gómez-Serrano, Elena Sommariva, José M. Fernández-Real, Francisco J. Ortega
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Plakophilin-2 (PKP2) is a key component of desmosomes, which, when defective, is known to promote the fibro-fatty infiltration of heart muscle. Less attention has been given to its role in adipose tissue. We report here that levels of PKP2 s
Externí odkaz:
https://doaj.org/article/c9aab534331a4f3fa90b32b90c48e65f
Autor:
Leticia Álvarez-Amor, Amparo Luque Sierra, Antonio Cárdenas, Lucía López-Bermudo, Javier López-Beas, Eloísa Andújar, Mónica Pérez-Alegre, Rocío Gallego-Durán, Lourdes M. Varela, Alejandro Martin-Montalvo, Genoveva Berná, Anabel Rojas, Mª José Robles-Frías, Abdelkrim Hmadcha, Manuel Romero-Gómez, Robert Kleemann, Franz Martín
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Dietary fatty acids play a role in the pathogenesis of obesity-associated non-alcoholic fatty liver disease (NAFLD), which is associated with insulin resistance (IR). Fatty acid composition is critical for IR and subsequent NAFLD development
Externí odkaz:
https://doaj.org/article/98018cb0ec61418692f64df0f9c6509c
Autor:
Eugenia Martin Vázquez, Nadia Cobo-Vuilleumier, Raquel Araujo Legido, Sandra Marín-Cañas, Emanuele Nola, Akaitz Dorronsoro, Lucia López Bermudo, Alejandra Crespo, Silvana Y. Romero-Zerbo, Maria García-Fernández, Alejandro Martin Montalvo, Anabel Rojas, Valentine Comaills, Francisco J. Bérmudez-Silva, Maureen Gannon, Franz Martin, Decio Eizirik, Petra I. Lorenzo, Benoit R. Gauthier
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104345- (2022)
Summary: LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation using the agonist BL001 protects islets against apoptosis, reverting hyperglycemia in mouse models of Type 1 Diabetes Mellitus. Islet transcriptome profiling re
Externí odkaz:
https://doaj.org/article/8058666987f74aa8a44031e045ebfaf8
Autor:
Andrea Di Francesco, Youngshim Choi, Michel Bernier, Yingchun Zhang, Alberto Diaz-Ruiz, Miguel A. Aon, Krystle Kalafut, Margaux R. Ehrlich, Kelsey Murt, Ahmed Ali, Kevin J. Pearson, Sophie Levan, Joshua D. Preston, Alejandro Martin-Montalvo, Jennifer L. Martindale, Kotb Abdelmohsen, Cole R. Michel, Diana M. Willmes, Christine Henke, Placido Navas, Jose Manuel Villalba, David Siegel, Myriam Gorospe, Kristofer Fritz, Shyam Biswal, David Ross, Rafael de Cabo
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 6, Iss 1, Pp 1-18 (2020)
Abstract Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesi
Externí odkaz:
https://doaj.org/article/fcd69445e0874cb1841372862929c6f9
Autor:
Abdelkrim Hmadcha, Alejandro Martin-Montalvo, Benoit R. Gauthier, Bernat Soria, Vivian Capilla-Gonzalez
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Mesenchymal stem cells (MSCs) are among the most frequently used cell type for regenerative medicine. A large number of studies have shown the beneficial effects of MSC-based therapies to treat different pathologies, including neurological disorders,
Externí odkaz:
https://doaj.org/article/f017bcafff6042bc80af1d5d1aae7c5d
Autor:
Evi M. Mercken, Miriam Capri, Bethany A. Carboneau, Maria Conte, Juliana Heidler, Aurelia Santoro, Alejandro Martin-Montalvo, Marta Gonzalez-Freire, Husam Khraiwesh, José A. González-Reyes, Ruin Moaddel, Yongqing Zhang, Kevin G. Becker, José M. Villalba, Julie A. Mattison, Ilka Wittig, Claudio Franceschi, Rafael de Cabo
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-22 (2017)
Conserved and unique aging regulatory pathways Aging is a complex phenomenon involving functional declines in multiple physiological systems with the passage of time. Focusing on skeletal muscle, a group of international scientists identified pathway
Externí odkaz:
https://doaj.org/article/7226c7ed427e4ac3ac7634971f4fca38
Autor:
Bernat Soria, Alejandro Martin-Montalvo, Yolanda Aguilera, Nuria Mellado-Damas, Javier López-Beas, Isabel Herrera-Herrera, Escarlata López, Juan A. Barcia, Manuel Alvarez-Dolado, Abdelkrim Hmadcha, Vivian Capilla-González
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Radiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation also causes detrimental effects in the healthy tissue, leading to neurocognitive sequelae that compromise the quality of life of brain cancer patients. Desp
Externí odkaz:
https://doaj.org/article/b726e4516afd48f2b3bd2ae16812d2a9
Autor:
Sarah J. Mitchell, Alejandro Martin-Montalvo, Evi M. Mercken, Hector H. Palacios, Theresa M. Ward, Gelareh Abulwerdi, Robin K. Minor, George P. Vlasuk, James L. Ellis, David A. Sinclair, John Dawson, David B. Allison, Yongqing Zhang, Kevin G. Becker, Michel Bernier, Rafael de Cabo
Publikováno v:
Cell Reports, Vol 6, Iss 5, Pp 836-843 (2014)
The prevention or delay of the onset of age-related diseases prolongs survival and improves quality of life while reducing the burden on the health care system. Activation of sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, improves metabolism and c
Externí odkaz:
https://doaj.org/article/4311e779c1b84073a91f71df14820ee9
Autor:
Antonio Campos-Caro, Eduardo García Fuentes, Francisco Javier Bermúdez-Silva, Nadia Cobo-Vuilleumier, Petra I. Lorenzo, Christian Claude Lachaud, Benoit R. Gauthier, Valentine Comaills, Esther Fuente-Martin, Jose C. Reyes, Alejandro Martin-Montalvo, Alejandra Crespo Barreda, José A Guerrero Martínez, Sabrina Rivero Canalejo, Jesús Ángel Pérez-Cabello, Franz Martín, Manuel Álvarez Dolado, José Manuel Mellado-Gil, Eugenia Martin Vázquez, Gemma Rojo-Martínez, Silvana Y. Romero-Zerbo, David Pozo, Jaime M. Franco, Manuel Aguilar-Diosdado, Livia López-Noriega
Publikováno v:
Theranostics
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Rationale: We recently demonstrated that the Metabesity factor HMG20A regulates islet beta-cell functional maturity and adaptation to physiological stress such as pregnancy and pre-diabetes. HMG20A also dictates central nervous system (CNS) developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353d6c4b8b7acf4f3e6f9f951fd6d22d
https://doi.org/10.7150/thno.57237
https://doi.org/10.7150/thno.57237
Autor:
Eugenia, Martin Vázquez, Nadia, Cobo-Vuilleumier, Raquel, Araujo Legido, Sandra, Marín-Cañas, Emanuele, Nola, Akaitz, Dorronsoro, Lucia, López Bermudo, Alejandra, Crespo, Silvana Y, Romero-Zerbo, Maria, García-Fernández, Alejandro, Martin Montalvo, Anabel, Rojas, Valentine, Comaills, Francisco J, Bérmudez-Silva, Maureen, Gannon, Franz, Martin, Decio, Eizirik, Petra I, Lorenzo, Benoit R, Gauthier
Publikováno v:
iScience. 25(5)
LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation using the agonist BL001 protects islets against apoptosis, reverting hyperglycemia in mouse models of Type 1 Diabetes Mellitus. Islet transcriptome profiling revealed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5bbd00ba6041914996c21743c543637
https://pubmed.ncbi.nlm.nih.gov/35602948
https://pubmed.ncbi.nlm.nih.gov/35602948