Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Alejandro, Gomez-Pinillos"'
Autor:
Tomasz M. Beer, Robert DiPaola, Dirk Moore, Xiaomei Liu, Alejandro Gomez-Pinillos, Ethan S. Barnett, James Babb, Mary-Ellen Taplin, Mark N. Stein, Joshi J. Alumkal, Anna C. Ferrari
Supplementary methods and Figure S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a6405920dc3429a827660650e46372
https://doi.org/10.1158/1078-0432.22472838
https://doi.org/10.1158/1078-0432.22472838
Autor:
Tomasz M. Beer, Robert DiPaola, Dirk Moore, Xiaomei Liu, Alejandro Gomez-Pinillos, Ethan S. Barnett, James Babb, Mary-Ellen Taplin, Mark N. Stein, Joshi J. Alumkal, Anna C. Ferrari
Purpose:This study assesses the action of panobinostat, a histone deacetylase inhibitor (HDACI), in restoring sensitivity to bicalutamide in a castration-resistant prostate cancer (CRPC) model and the efficacy and safety of the panobinostat/bicalutam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87950aab186a81f17fca984be3bf2175
https://doi.org/10.1158/1078-0432.c.6528345.v1
https://doi.org/10.1158/1078-0432.c.6528345.v1
Autor:
Dirk F. Moore, Anna C. Ferrari, Joshi J. Alumkal, Xiaomei Liu, Ethan S Barnett, Tomasz M. Beer, James S. Babb, Mary-Ellen Taplin, Alejandro Gomez-Pinillos, Robert S. DiPaola, Mark N. Stein
Publikováno v:
Clinical Cancer Research. 25:52-63
Purpose: This study assesses the action of panobinostat, a histone deacetylase inhibitor (HDACI), in restoring sensitivity to bicalutamide in a castration-resistant prostate cancer (CRPC) model and the efficacy and safety of the panobinostat/bicaluta
Autor:
Sharon Friedlander, Jordi Rodon, Anthony J. Olszanski, Alonzo Martinez, Ulka N. Vaishampayan, Arkadiusz Z. Dudek, Robert Gharavi, John F. Gibbs, Bo Chao, Afshin Dowlati, Christine K. Ward, Bingxia Wang, Alejandro Gomez-Pinillos, Dejan Juric, Vaishali Shinde, Hadeel Assad, Allison Berger, Igor Proscurshim
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A505-A506
BackgroundSUMOylation is a post-translational modification that serves as an important modulator of immune responses via its role in constraining the type I interferon (IFN-1) response. TAK-981 is a small molecule that inhibits SUMOylation and increa
Autor:
Sanjay Goel, Susanna Varkey Ulahannan, Anthony J. Olszanski, Patricia LoRusso, Rachel E. Sanborn, Sunil Sharma, Leisha A. Emens, Matthew Reilley, Victor Priego, Shuli Li, Bingxia Wang, Lixian Dong, Kris Sachsenmeier, John Gibbs, Robert Gharavi, Alonzo Martinez, Igor Proscurshim, Robert J. Fram, Alejandro Gomez-Pinillos, Drew W. Rasco
Publikováno v:
Journal of Clinical Oncology. 40:2506-2506
2506 Background: SUMOylation is a post-translational modification with a role in limiting type 1 interferon (IFN-1)-dependent immune responses. Subasumstat is a small-molecule inhibitor of SUMOylation with the potential to increase antitumor immunity
Autor:
Alejandro Gomez-Pinillos, Alonzo Martinez, Allison Berger, Amitkumar Mehta, Deborah Berg, Stephane Doucet, Paolo Caimi, Tycel Phillips, Lapo Alinari, Brenda W. Cooper, Bo Chao, Christine K. Ward, Igor Proscurshim, John Gibbs, Sarit Assouline, Alexey V. Danilov, Sharon Friedlander, Steven I. Park
Publikováno v:
Blood. 138:2488-2488
Background: TAK-981 is the first small-molecule inhibitor of SUMOylation to enter clinical trials. SUMOylation is a post-translational modification in which small ubiquitin-like modifier (SUMO) proteins are activated and covalently attached to substr
Autor:
Erlene K. Seymour, Allison Berger, Dennis Huszar, Dejan Juric, Afshin Dowlati, Igor Proscurshim, Anthony J. Olszanski, Alejandro Gomez-Pinillos, Jordi Rodon Ahnert, Bingxia Wang, Arkadiusz Z. Dudek, Sharon Friedlander
Publikováno v:
Journal of Clinical Oncology. 39:TPS2667-TPS2667
TPS2667 Background: SUMOylation, a posttranslational modification analogous to ubiquitination, attaches a small, ubiquitin-like modifier (SUMO) to target proteins. SUMOylation plays a central role in regulating type I interferon (IFN-I)-dependent inn
Autor:
Xiaomei Liu, Alejandro Gomez-Pinillos, James Babb, Tomasz M. Beer, Robert S. DiPaola, A. Ferrari, Mary-Ellen Taplin, Dirk F. Moore, Ethan Barnett, Joshi J. Alumkal, Mark N. Stein
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(8)
Autor:
Dennis Huszar, Allison Berger, Alejandro Gomez-Pinillos, Mi-Sook Kim, Amitkumar Mehta, Igor Proscurshim, Chirag Patel, Paolo Caimi, Bingxia Wang, Sarit Assouline, Sharon Friedlander
Publikováno v:
Blood. 134:1593-1593
Background TAK-981 is a first-in-class, small molecule inhibitor of SUMOylation, a reversible post-translational modification that regulates protein function by covalent attachment of small ubiquitin-like modifier (SUMO) proteins to a protein substra
Autor:
Jose Manuel Trigo Perez, Alejandro Gomez-Pinillos, Amanda Wren, Javier Cortes, Esther Holgado
Publikováno v:
The Lancet Oncology. 16:1591-1593