Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Alejandro, Carazo"'
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
The human body is regularly exposed to simple catechols and small phenols originating from our diet or as a consequence of exposure to various industrial products. Several biological properties have been associated with these compounds such as antiox
Externí odkaz:
https://doaj.org/article/ed3ac4eed5224cf295633e03b841cb7f
Autor:
Alejandro Carazo, Marcel Hrubša, Lukáš Konečný, Catherine Gunaseelan, Jaka Fadraersada, Pavel Skořepa, Markéta Paclíková, František Musil, Jana Karlíčková, Lenka Javorská, Kateřina Matoušová, Lenka Kujovská Krčmová, Alena Šmahelová, Vladimír Blaha, Přemysl Mladenka
Publikováno v:
Platelets, Vol 35, Iss 1 (2024)
AbstractPlatelet aggregation is a complicated process mediated by different signaling pathways. As the process is highly complex and apparently redundant, the relationships between these pathways are not yet fully known. The aim of this project was t
Externí odkaz:
https://doaj.org/article/240926563f954eb0a303bf7cf0825291
Autor:
Lukáš Konečný, Marcel Hrubša, Jana Karlíčková, Alejandro Carazo, Lenka Javorská, Kateřina Matoušová, Lenka Kujovská Krčmová, Alena Šmahelová, Vladimír Blaha, Milan Bláha, Přemysl Mladěnka
Publikováno v:
Nutrients, Vol 15, Iss 8, p 1842 (2023)
Elevated low-density lipoprotein (LDL) cholesterol levels lead to atherosclerosis and platelet hyperaggregability, both of which are known culprits of arterial thrombosis. Normalization of LDL cholesterol in familial hypercholesterolemia (FH) is not
Externí odkaz:
https://doaj.org/article/156359b5421848248bde0c4db94cc5ba
Autor:
Marcel Hrubša, Lukáš Konečný, Markéta Paclíková, Mst Shamima Parvin, Pavel Skořepa, František Musil, Jana Karlíčková, Lenka Javorská, Kateřina Matoušová, Lenka Kujovská Krčmová, Alejandro Carazo, Alena Šmahelová, Vladimír Blaha, Přemysl Mladěnka
Publikováno v:
Nutrients, Vol 14, Iss 22, p 4798 (2022)
A polyphenol-rich diet has beneficial effects on cardiovascular health. However, dietary polyphenols generally have low bioavailability and reach low plasma concentrations. Small phenolic metabolites of these compounds formed by human microbiota are
Externí odkaz:
https://doaj.org/article/bfc55a3a0a63437689df8135ddb9e254
Autor:
Mst Shamima Parvin, Marcel Hrubša, Jaka Fadraersada, Alejandro Carazo, Jana Karlíčková, Lucie Cahlíková, Jakub Chlebek, Kateřina Macáková, Přemysl Mladěnka
Publikováno v:
Toxins, Vol 14, Iss 7, p 491 (2022)
Isoquinoline alkaloids have multiple biological activities, which might be associated with positive pharmacological effects as well as negative adverse reactions. As bleeding was suggested to be a side effect of the isoquinoline alkaloid berberine, w
Externí odkaz:
https://doaj.org/article/e3005161ac514ba2b27ae769110251cd
Autor:
Marcel Hrubša, Raúl Alva, Mst Shamima Parvin, Kateřina Macáková, Jana Karlíčková, Jaka Fadraersada, Lukáš Konečný, Monika Moravcová, Alejandro Carazo, Přemysl Mladěnka
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 117 (2022)
Flavonoids are associated with positive cardiovascular effects. However, due to their low bioavailability, metabolites are likely responsible for these properties. Recently, one of these metabolites, 4-methylcatechol, was described to be a very poten
Externí odkaz:
https://doaj.org/article/60172e55a63f4923982ab2576e429a7d
Autor:
Charalampos Kamoutsis, Maria Fesatidou, Anthi Petrou, Athina Geronikaki, Vladimir Poroikov, Marija Ivanov, Marina Soković, Ana Ćirić, Alejandro Carazo, Přemysl Mladěnka
Publikováno v:
Antibiotics, Vol 10, Iss 7, p 804 (2021)
The goal of this research is to investigate the antimicrobial activity of nineteen previously synthesized 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives. The compounds were tested against a panel of three Gram-positive and thre
Externí odkaz:
https://doaj.org/article/14e9e06009c845bea7dd2619caf37c1d
Autor:
Marina Zveaghintseva, Eugenia Stingaci, Serghei Pogrebnoi, Anastasia Smetanscaia, Vladimir Valica, Livia Uncu, Victor Ch. Kravtsov, Elena Melnic, Anthi Petrou, Jasmina Glamočlija, Marina Soković, Alejandro Carazo, Přemysl Mladěnka, Vladimir Poroikov, Athina Geronikaki, Fliur Z. Macaev
Publikováno v:
Molecules, Vol 26, Iss 14, p 4304 (2021)
Herein we report the synthesis of some new 1H-1,2,4-triazole functionalized chromenols (3a–3n) via tandem reactions of 1-(alkyl/aryl)-2-(1H-1,2,4-triazole-1-yl) with salicylic aldehydes and the evaluation of their antifungal activity. In silico pre
Externí odkaz:
https://doaj.org/article/9df929bfd0284073a33102735d381583
Autor:
Lukáš Konečný, Marcel Hrubša, Jana Karlíčková, Alejandro Carazo, Lenka Javorská, Kateřina Matoušová, Lenka Kujovská Krčmová, Vladimír Blaha, Milan Bláha, Přemysl Mladěnka
Publikováno v:
Cardiovascular Drugs and Therapy.
Background and aims It is well known that elevated cholesterol is associated with enhanced platelet aggregation and patients suffering from familial hypercholesterolemia (FH) have a high risk of thrombotic cardiovascular events. Although decreasing c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2ba33f932a3cb1250ecd6e4ba3292e2
https://doi.org/10.1007/s10557-023-07455-y
https://doi.org/10.1007/s10557-023-07455-y
Autor:
Alejandro Carazo, Kateřina Macáková, Kateřina Matoušová, Lenka Kujovská Krčmová, Michele Protti, Přemysl Mladěnka
Publikováno v:
Nutrients, Vol 13, Iss 5, p 1703 (2021)
Vitamin A is a group of vital micronutrients widely present in the human diet. Animal-based products are a rich source of the retinyl ester form of the vitamin, while vegetables and fruits contain carotenoids, most of which are provitamin A. Vitamin
Externí odkaz:
https://doaj.org/article/bfac3cbd4efc43c1aa317168be2ecc51