Výsledky vyhledávání - "Alejandra Moure"

Akademický článek

Semaphorin 3A—Glycosaminoglycans Interaction as Therapeutic Target for Axonal Regeneration

Autor: Yolanda Pérez, Roman Bonet, Miriam Corredor, Cecilia Domingo, Alejandra Moure, Àngel Messeguer, Jordi Bujons, Ignacio Alfonso

Publikováno v: Pharmaceuticals, Vol 14, Iss 9, p 906 (2021)

Semaphorin 3A (Sema3A) is a cell-secreted protein that participates in the axonal guidance pathways. Sema3A acts as a canonical repulsive axon guidance molecule, inhibiting CNS regenerative axonal growth and propagation. Therefore, interfering with S

Externí odkaz: https://doaj.org/article/ffdfb672a5f94450b00dc8e558f259e3

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Akademický článek

Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity.

Autor: Mar Orzáez, Mónica Sancho, Sandra Marchán, Laura Mondragón, Rebeca Montava, Juan García Valero, Olatz Landeta, Gorka Basañez, Rodrigo J Carbajo, Antonio Pineda-Lucena, Jordi Bujons, Alejandra Moure, Angel Messeguer, Carmen Lagunas, Carmen Herrero, Enrique Pérez-Payá

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e110979 (2014)

Excessive apoptosis induces unwanted cell death and promotes pathological conditions. Drug discovery efforts aimed at decreasing apoptotic damage initially targeted the inhibition of effector caspases. Although such inhibitors were effective, safety

Externí odkaz: https://doaj.org/article/3e08645d6c474a99896aed935439ac6b

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Akademický článek

Protein-protein interaction antagonists as novel inhibitors of non-canonical polyubiquitylation.

Autor: Johanna Scheper, Marta Guerra-Rebollo, Glòria Sanclimens, Alejandra Moure, Isabel Masip, Domingo González-Ruiz, Nuria Rubio, Bernat Crosas, Oscar Meca-Cortés, Noureddine Loukili, Vanessa Plans, Antonio Morreale, Jerónimo Blanco, Angel R Ortiz, Angel Messeguer, Timothy M Thomson

Publikováno v: PLoS ONE, Vol 5, Iss 6, p e11403 (2010)

BACKGROUND: Several pathways that control cell survival under stress, namely RNF8-dependent DNA damage recognition and repair, PCNA-dependent DNA damage tolerance and activation of NF-kappaB by extrinsic signals, are regulated by the tagging of key p

Externí odkaz: https://doaj.org/article/5e9127a24934479b8668f5d2bd51efe2

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Semaphorin 3A-Glycosaminoglycans Interaction as Therapeutic Target for Axonal Regeneration

Autor: Roman Bonet, Miriam Corredor, Cecilia Domingo, Ignacio Alfonso, Alejandra Moure, Yolanda Pérez, Jordi Bujons, Angel Messeguer

Publikováno v: Pharmaceuticals
Digital.CSIC. Repositorio Institucional del CSIC
instname
Pharmaceuticals, Vol 14, Iss 906, p 906 (2021)
Volume 14
Issue 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be49cddbab2ef7069ed9f861385ab33
https://pubmed.ncbi.nlm.nih.gov/34577606

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Triazine-Based Vanilloid 1 Receptor Open Channel Blockers: Design, Synthesis, Evaluation, and SAR Analysis

Autor: Asia Fernández-Carvajal, Jordi Bujons, Angel Messeguer, Miquel Vidal-Mosquera, Antonio Ferrer-Montiel, Rosa Planells-Cases, Alejandra Moure, José M. González-Ros, Pierluigi Valente

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
JOURNAL OF MEDICINAL CHEMISTRY
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

The thermosensory transient receptor potential vanilloid 1 channel (TRPV1) is a polymodal receptor activated by physical and chemical stimuli. TRPV1 activity is drastically potentiated by proinflammatory agents released upon tissue damage. Given the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa22b6885dfa239975adae1071d9a68
https://doi.org/10.1021/jm200981s

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Anti-Tat and anti-HIV activities of trimers of n-alkylglycines

Autor: Nieves Marquez, Isabel Masip, Eduardo Muñoz, Rocioo Sancho, Antonio Macho, Angel Messeguer, Alejandra Moure

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

9 pages, 7 figures.
Transcription of human immunodeficiency virus (HIV-1) is activated by viral Tat protein which regulates HIV–LTR transcription and elongation. In the present report, the evaluation of the anti-Tat activity of a combinatorial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65afbae497528c8353a3ae174722436
https://doi.org/10.1016/j.bcp.2005.11.024

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The emergence of halophilic evolutionary patterns from a dynamic combinatorial library of macrocyclic pseudopeptides

Autor: Ignacio Alfonso, Alejandra Moure, Joan Atcher

Publikováno v: Chem. Commun.. 49:487-489

The increase of the ionic strength amplifies the species bearing acidic side chains from a bio-inspired dynamic combinatorial library of macrocyclic pseudopeptides, in close resemblance to the evolution observed for the proteins of halophilic microor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618023628291151070ed9e66018a027b
https://doi.org/10.1039/c2cc37869h

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Salt-induced adaptation of a dynamic combinatorial library of pseudopeptidic macrocycles: unraveling the electrostatic effects in mixed aqueous media

Autor: Ignacio Alfonso, Jordi Bujons, Joan Atcher, Alejandra Moure

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 21(18)

Dynamic combinatorial libraries are powerful systems for studying adaptive behaviors and relationships, as models of more complex molecular networks. With this aim, we set up a chemically diverse dynamic library of pseudopeptidic macrocycles containi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f367d908c7d7bb7f602b71341ff1397
https://pubmed.ncbi.nlm.nih.gov/25777367

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Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity

Autor: Sandra Marchán, Gorka Basañez, Rodrigo J. Carbajo, Jordi Bujons, Angel Messeguer, Laura Mondragón, Olatz Landeta, Mar Orzáez, Enrique Pérez-Payá, Antonio Pineda-Lucena, Rebeca Montava, Juan G. Valero, Mónica Sancho, Alejandra Moure, Carmen Lagunas, Carmen Herrero

Publikováno v: Plos One
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
Digital.CSIC. Repositorio Institucional del CSIC
Addi. Archivo Digital para la Docencia y la Investigación
PLoS ONE, Vol 9, Iss 10, p e110979 (2014)
PLoS ONE
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

11 páginas, 4 figuras.
BACKGROUND: Excessive apoptosis induces unwanted cell death and promotes pathological conditions. Drug discovery efforts aimed at decreasing apoptotic damage initially targeted the inhibition of effector caspases. Althoug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540b28fdd9b9bb28d9e5c84231014563
http://hdl.handle.net/10261/103949

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Pseudopeptidic Cages as Receptors for N-Protected Dipeptides

Autor: Alejandra Moure, Ignacio Alfonso, Enrico Faggi, Cristian Vicent, Santiago V. Luis, Michael Bolte

The molecular recognition of short peptides is a challenge in supramolecular chemistry, and the use of peptide-like cage receptors represents a promising approach. Here we report the synthesis and characterization of a diverse family of pseudopeptidi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0882a0d921d9a9a07eeb8de9bca66c80

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