Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alejandra M. Pacchioni"'
Publikováno v:
Pharmacology Biochemistry and Behavior. 103:373-379
Evidence suggests that cocaine addiction may involve progressive neuroadaptive changes in the dorsolateral caudate putamen (dlCPu). While cocaine seeking following abstinence from chronic self-administration requires intact dlCPu function, in vivo ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ab39ac43c19199119d8790894f27e9
https://doi.org/10.1016/j.pbb.2012.09.015
https://doi.org/10.1016/j.pbb.2012.09.015
Autor:
Jacqueline F. McGinty, Ronald E. See, Alejandra M. Pacchioni, Peter W. Kalivas, Angelica Rocha, Marek Schwendt
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 331:555-562
Chronic abuse of methamphetamine leads to cognitive dysfunction and high rates of relapse, paralleled by significant changes of brain dopamine and serotonin neurotransmission. Previously, we found that rats with extended access to methamphetamine sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526b67a93997aef1c1ce1158997ed12f
https://doi.org/10.1124/jpet.109.155770
https://doi.org/10.1124/jpet.109.155770
Publikováno v:
Molecular and Cellular Pharmacology. 1:71-75
Glutamate AMPA receptors (AMPAR) in the nucleus accumbens have an important role in cocaine-induced neuroadaptations. Neuronal pentraxins function in the extracellular matrix to bind AMPAR. Three neuronal pentraxins have been described Narp, NP1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0173994397fe4ceadf19e0e54840f6c6
https://doi.org/10.4255/mcpharmacol.09.08
https://doi.org/10.4255/mcpharmacol.09.08
Autor:
Antonieta Lavin, Alejandra M. Pacchioni, Justin T. Gass, Peter W. Kalivas, Khaled Moussawi, M. Foster Olive, Megan M. Moran
Publikováno v:
Nature neuroscience
Cocaine addiction is characterized by an impaired ability to develop adaptive behaviors that can compete with cocaine seeking, implying a deficit in the ability to induce plasticity in cortico-accumbens circuitry crucial for regulating motivated beha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54cdb34ca77b6d38b2cc1b4f70b8f4e
https://doi.org/10.1038/nn.2250
https://doi.org/10.1038/nn.2250
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:183-192
Neuronal pentraxins (NPs) function in the extracellular matrix to bind alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Three NPs have been described, neuronal activity-regulated pentraxin (Narp), which is regulated as an im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b779b52eeb0f2024f87f01a181d71402
https://doi.org/10.1124/jpet.108.143115
https://doi.org/10.1124/jpet.108.143115
Autor:
Thomas L. Saunders, Kevin C Lord, Thomas W. Gettys, Alejandra M. Pacchioni, Kurt J. Varner, Cory Black, Eric Lazartigues, Joe B. Blumer, Stephen M. Lanier
Publikováno v:
Endocrinology. 149:3842-3849
Activator of G protein signaling (AGS)-3 plays functional roles in cell division, synaptic plasticity, addictive behavior, and neuronal development. As part of a broad effort to define the extent of functional diversity of AGS3-regulated-events in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510a4798262f2e24ea5510f767ca5f3d
https://doi.org/10.1210/en.2008-0050
https://doi.org/10.1210/en.2008-0050
Autor:
Alana C. Conti, Scott A. Mackler, Julie A. Blendy, Peter W. Kalivas, Ryan Degnan, Ying Homan, Alejandra M. Pacchioni
Publikováno v:
Behavioural Brain Research. 187:48-55
NAC1 is a novel member of the POZ/BTB (Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad complex) but varies from other proteins of this class in that it lacks the characteristic DNA-binding motif, suggesting a novel role. We have employed consti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d23b28ce55fd6a2620c6c1ed46a627d
https://doi.org/10.1016/j.bbr.2007.08.036
https://doi.org/10.1016/j.bbr.2007.08.036
Autor:
Heather A. Boger, Emily D. Denehy, Kennerly S. Patrick, Sammanda Ramamoorthy, Alejandra M. Pacchioni, Jacqueline F. McGinty, Ann-Charlotte Granholm, Hao Jie Zhu, Lawrence D. Middaugh
Publikováno v:
The Journal of Neuroscience. 27:8816-8825
Methamphetamine abuse in young adults has long-term deleterious effects on brain function that are associated with damage to monoaminergic neurons. Administration of glial cell line-derived neurotrophic factor (GDNF) protects dopamine neurons from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d3b15c4bbbbc4f6c3007860a10426f
https://doi.org/10.1523/jneurosci.1067-07.2007
https://doi.org/10.1523/jneurosci.1067-07.2007
Autor:
Alejandra M. Pacchioni, Roberto I. Melendez, Andy Y. Shih, Joseph Vallone, Timothy H. Murphy, Peter W. Kalivas
Publikováno v:
Brain Research. 1127:26-35
The transcription factor NF-E2-related factor (Nrf2) regulates the induction of phase 2 detoxifying enzymes by oxidative stress, including synthesis of the catalytic subunit (xCT) of the heterodimeric cystine-glutamate exchanger (system xc-). Repeate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bc3f0c37caba2479cfb3ab7ddcde2a
https://doi.org/10.1016/j.brainres.2006.10.036
https://doi.org/10.1016/j.brainres.2006.10.036
Autor:
Santiago, Cuesta, Maria J, Severin, Jorgelina, Batuecas, Silvana B, Rosso, Alejandra M, Pacchioni
Publikováno v:
Addiction biology. 22(4)
Behavioral sensitization is a progressive and enduring enhancement of the motor stimulant effects elicited by repeated administration of drugs of abuse. It can be divided into two distinct temporal and anatomical domains, termed initiation and expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::82b636364bfc994a082f310b467ca24c
https://pubmed.ncbi.nlm.nih.gov/26910786
https://pubmed.ncbi.nlm.nih.gov/26910786