Výsledky vyhledávání - "Alejandra Klauer King"

Akademický článek

Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohn’s Disease

Autor: Julie E. Horowitz, Neil Warner, Jeffrey Staples, Eileen Crowley, Nehal Gosalia, Ryan Murchie, Cristopher Van Hout, Karoline Fiedler, Gabriel Welch, Alejandra Klauer King, Jeffrey G. Reid, John D. Overton, Aris Baras, Alan R. Shuldiner, Anne Griffiths, Omri Gottesman, Aleixo M. Muise, Claudia Gonzaga-Jauregui

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Abstract Inflammatory bowel disease (IBD), clinically defined as Crohn’s disease (CD), ulcerative colitis (UC), or IBD-unclassified, results in chronic inflammation of the gastrointestinal tract in genetically susceptible hosts. Pediatric onset IBD

Externí odkaz: https://doaj.org/article/1f5de0d61ecd4e8a964ff8857b3099dd

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The Mtr4 ratchet helix and arch domain both function to promote RNA unwinding

Autor: Ambro van Hoof, Lindsey K. Lott, Alejandra Klauer King, Lacy L. Taylor, Megi Rexhepaj, Ryan N. Jackson, Sean J. Johnson

Publikováno v: Nucleic Acids Research
Chemistry and Biochemistry Faculty Publications

Mtr4 is a conserved Ski2-like RNA helicase and a subunit of the TRAMP complex that activates exosome-mediated 3'-5' turnover in nuclear RNA surveillance and processing pathways. Prominent features of the Mtr4 structure include a four-domain ring-like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d4f3c2d2eb4cf93e1ba2dbfc61d4a1
https://doi.org/10.1093/nar/gku1208

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Interaction between the RNA-dependent ATPase and poly(A) polymerase subunits of the TRAMP complex is mediated by short peptides and important for snoRNA processing

Autor: Alejandra Klauer King, Sean J. Johnson, Lacy L. Taylor, John Loomis, Jillian S. Losh, Ambro van Hoof, Jason A. Rosenzweig, Jeremy Bakelar

Publikováno v: Nucleic Acids Research

The RNA exosome is one of the main 3′ to 5′ exoribonucleases in eukaryotic cells. Although it is responsible for degradation or processing of a wide variety of substrate RNAs, it is very specific and distinguishes between substrate and non-substr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b141217d258c7e1323825914cea84463
https://pubmed.ncbi.nlm.nih.gov/25589546

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