Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alejandra De Angulo"'
Autor:
Ke Yun Chen, Alejandra De Angulo, Xin Guo, Aditya More, Scott A. Ochsner, Eduardo Lopez, David Saul, Weijun Pang, Yuxiang Sun, Neil J. McKenna, Qiang Tong
Publikováno v:
Frontiers in Aging, Vol 2 (2022)
Objective: Although PU.1/Spi1 is known as a master regulator for macrophage development and function, we have reported previously that it is also expressed in adipocytes and is transcriptionally induced in obesity. Here, we investigated the role of a
Externí odkaz:
https://doaj.org/article/c980109b2e3242598cea0ee28758123b
Publikováno v:
Nutrition and Cancer. 74:650-659
Obesity is associated with low-grade chronic inflammation, and metabolic dysregulation. Evidence shows that chronic inflammation inhibits protective immunity mediated by CD4+ T cells. Additionally, obesity-induced inflammation affects prostate cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17b40312cad54f8f577ef9b66473039
https://doi.org/10.1080/01635581.2021.1898649
https://doi.org/10.1080/01635581.2021.1898649
Autor:
Yuxiang Sun, David Saul, Weijun Pang, Qiang Tong, Scott A. Ochsner, Alejandra De Angulo, Eduardo Lopez, Aditya More, Neil J. McKenna, Keyun Chen, Xin Guo
ObjectiveAlthough PU.1/Spi1 is known as a master regulator for macrophage development and function, we have reported previously that it is also expressed in adipocytes and is transcriptionally induced in obesity. Here, we investigated the role of adi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::433e5c47b52d5c97509b8216319776d3
https://doi.org/10.1101/2021.08.29.458103
https://doi.org/10.1101/2021.08.29.458103
Autor:
Linda A. deGraffenried, Christopher A. Jolly, Peyton Travis, Margaret Kappel, Michael Adkison, Brittany Harlow, Alejandra De Angulo
Publikováno v:
Cancer Research. 81:2793-2793
Background: Prostate cancer remains the second leading cause of cancer related deaths in men and obesity has been shown to severely impact its prognosis. Previous studies in our laboratory have shown that CD4+ T cells polarized under obese conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3187064d945ccfec456f1531bd6ddddf
https://doi.org/10.1158/1538-7445.am2021-2793
https://doi.org/10.1158/1538-7445.am2021-2793
Autor:
Linda A. deGraffenried, Benjamin J. Daniel, Christopher A. Jolly, Alejandra De Angulo, Robert Faris
Publikováno v:
The Prostate. 75:449-462
Background A close relationship between aging, inflammation, and prostate cancer is widely accepted. Aging is accompanied by a progressive increase in pro-inflammatory cytokines, including interleukin 17 (IL-17), a key pro-inflammatory cytokine that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dff68917af9a065bb23b723489f5929
https://doi.org/10.1002/pros.22931
https://doi.org/10.1002/pros.22931
Publikováno v:
Cancer Research. 78:61-61
Obese men are at greater risk of developing an aggressive form of prostate cancer. The T cell population from obese subjects have shown signatures of cell senescence including shortened telomeres and elevated production of proinflammatory cytokines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::881cb93018ab48eaf4e6026f88e57b3e
https://doi.org/10.1158/1538-7445.am2018-61
https://doi.org/10.1158/1538-7445.am2018-61
Publikováno v:
Frontiers in Immunology. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb45ebcc2b4bf33bd753f290d406dc95
https://doi.org/10.3389/conf.fimmu.2015.05.00053
https://doi.org/10.3389/conf.fimmu.2015.05.00053
Autor:
Alejandra De Angulo, Robert Faris, Linda A. deGraffenried, Robert S. Chapkin, Yang-Yi Fan, Christopher A. Jolly
Glycerol-3-phosphate acyltransferase-1 is the first rate limiting step in de novo glycerophospholipid synthesis. We have previously demonstrated that GPAT-1 deletion can significantly alter T cell function resulting in a T cell phenotype similar to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf9cc95d6b1bff932fa102ecf9d3046
https://europepmc.org/articles/PMC4169305/
https://europepmc.org/articles/PMC4169305/
Autor:
Christopher A. Jolly, Robert Faris, Linda A. deGraffenried, David Cavazos, Benajmin Daniel, Alejandra De Angulo
Publikováno v:
The Prostate. 73(8)
BACKGROUND The primary risk for prostate cancer is aging, often associated with inflammation. Evidence implicates progressive age-related immune dysfunction with increased prostate cancer incidence and mortality. The aged T-cell response is character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217cbcf429e0458151e53dfb5de426ca
https://pubmed.ncbi.nlm.nih.gov/24445295
https://pubmed.ncbi.nlm.nih.gov/24445295
Autor:
Christopher A. Jolly, Shruti A. Apte, Robert Faris, Ramona Salcedo, Alejandra De Angulo, Cindy Chen, David Cavazos, Linda A. deGraffenried
Publikováno v:
Cancer Research. 70:2472-2472
As men age past 40, their chance of developing prostate cancer increases exponentially each year. The mechanism by which age influences the risk of prostate cancer remains largely unknown, hindering the development of effective preventive interventio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c8dd3fcc6412a1c791a48f84c9e9ee2
https://doi.org/10.1158/1538-7445.am10-2472
https://doi.org/10.1158/1538-7445.am10-2472