Výsledky vyhledávání - "Alejandra Cely-Ortiz"

Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling

Autor: Carlos Alfredo Valverde, Evangelia G. Kranias, Leandro A. Diaz-Zegarra, Jorge A. Negroni, Juan Ignacio Felice, Ernesto A. Aiello, Marilén Federico, Elena C. Lascano, Alejandra Cely-Ortiz, Alicia Mattiazzi, Julieta Palomeque, Xander H.T. Wehrens

Publikováno v: The Journal of General Physiology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The present work shows that SR Ca2+ load and RYR2 Ca2+ sensitivity are major determinants of Ca2+ release restitution (CRR) after each heartbeat. Mathematical modeling led us to speculate that the velocity of SR Ca2+ refilling might regulate CRR inde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badfe85072de9cb42229aa1660c69f52
https://doi.org/10.1085/jgp.201912512

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Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors

Autor: Juan Ignacio Felice, Mariano N Di Carlo, Enrique Leo Portiansky, Alejandra Cely-Ortiz, Carlos Alfredo Valverde, Alicia Elvira Consolini, Evangelia G. Kranias, Gabriela Mazzocchi, Alicia Mattiazzi, Xander H.T. Wehrens, Nehuen Salas, Susana M. Mosca, María Inés Ragone, Alejandro Ciocci Pardo

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Aims Abnormal Ca2+ release from the sarcoplasmic reticulum (SR), associated with Ca2+-calmodulin kinase II (CaMKII)-dependent phosphorylation of RyR2 at Ser2814, has consistently been linked to arrhythmogenesis and ischaemia/reperfusion (I/R)-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb312af627bc1a43478e0f41e25969aa
http://sedici.unlp.edu.ar/handle/10915/124352

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