Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer’s disease

Autor: Carolina A. Oliva, Matías Lira, Claudia Jara, Alejandra Catenaccio, Trinidad A. Mariqueo, Carolina B. Lindsay, Francisco Bozinovic, Grisel Cavieres, Nibaldo C. Inestrosa, Cheril Tapia-Rojas, Daniela S. Rivera

Publikováno v: Frontiers in Aging Neuroscience, Vol 15 (2023)

Social interactions have a significant impact on health in humans and animal models. Social isolation initiates a cascade of stress-related physiological disorders and stands as a significant risk factor for a wide spectrum of morbidity and mortality

Externí odkaz: https://doaj.org/article/14d0878ab9b747d19ede0b7e1c46b3ee

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein

Autor: Daniela, Elgueta, Ornella, Chovar, Valentina, Ugalde, Vanesa, Sánchez-Guajardo, Alejandra, Catenaccio, Felipe, Court, Rodrigo, Pacheco

Publikováno v: Journal of visualized experiments : JoVE. (185)

Parkinson's disease is a neurodegenerative disorder that involves the death of the dopaminergic neurons of the nigrostriatal pathway and, consequently, the progressive loss of control of voluntary movements. This neurodegenerative process is triggere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ee16cab45580b0efb7c775e4b550496
https://pubmed.ncbi.nlm.nih.gov/35969046

Collateral Sprouting of Peripheral Sensory Neurons Exhibits a Unique Transcriptomic Profile

Autor: Maritza Oñate, Gabriela Martínez, Thomas M. Wishart, Dominique Lemaitre, Maica Llavero Hurtado, Cristian De Gregorio, Alejandra Catenaccio, Felipe A. Court

Publikováno v: Lemaitre, D, Llavero hurtado, M, De Gregorio, C, Oñate, M, Martínez, G, Catenaccio, A, Wishart, T & Court, F A 2020, ' Collateral sprouting of peripheral sensory neurons exhibits a unique transcriptomic profile ', Molecular Neurobiology . https://doi.org/10.1007/s12035-020-01986-3

Background: Peripheral nerve injuries result in motor and sensory dysfunction which can be recovered by compensatory or regenerative processes. In situations where axonal regeneration of injured neurons is hampered, compensation by collateral sprouti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56bdbcf8b9b8c2210ee73f6ddd7ed5a
https://doi.org/10.1007/s12035-020-01986-3

The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease

Autor: Paulina Soto, Nazaret Gamez, Felipe A. Court, Alexis Martinez, Claudio Soto, Natalia Salvadores, Maritza Oñate, Cristian Saquel, Alejandra Catenaccio, Claudio Hetz, Ines Moreno-Gonzalez

Publikováno v: Cell Death Differ
Cell Death & Differentiation

Parkinson’s disease (PD) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of dopaminergic neurons in the substantia nigra and depletion of dopamine release in the striatum.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f327937501d6d542ace26edb9a73e50

Axonal Degeneration Is Mediated by Necroptosis Activation

Autor: Felipe A. Court, Macarena S. Arrázola, Nicolas W. Martinez, Romina J. Catalán, Diego E. Hernandez, Cristian Saquel, Sebastian A. Barrientos, Alejandra Catenaccio

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(20)

Axonal degeneration, which contributes to functional impairment in several disorders of the nervous system, is an important target for neuroprotection. Several individual factors and subcellular events have been implicated in axonal degeneration, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b29d9d7552cde3568a5ebc300ec353f
https://pubmed.ncbi.nlm.nih.gov/30850513