Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Alejandra, Mondino"'
Autor:
Katherine E. Simon, Katharine Russell, Alejandra Mondino, Chin-Chieh Yang, Beth C. Case, Zachary Anderson, Christine Whitley, Emily Griffith, Margaret E. Gruen, Natasha J. Olby
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Age-related decline in mobility and cognition are associated with cellular senescence and NAD + depletion in dogs and people. A combination of a novel NAD + precursor and senolytic, LY-D6/2, was examined in this randomized controlled trial.
Externí odkaz:
https://doaj.org/article/fe8940694bdf4905b3f233e0ac4ebea5
Autor:
Katharine J. Russell, Alejandra Mondino, Gilad Fefer, Emily Griffith, Korinn Saker, Margaret E. Gruen, Natasha J. Olby
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
IntroductionFrailty is a well-defined clinical syndrome in humans caused by accumulation of impairments which result in loss of reserve capacity and increased vulnerability to disability, dependence, and death. Dogs are of particular interest in stud
Externí odkaz:
https://doaj.org/article/789deb5fb41d4673a1a472704422bbc3
Autor:
Alejandra Mondino, Chin-Chieh Yang, Katherine E Simon, Gilad Fefer, James Robertson, Margaret E Gruen, Natasha J Olby
Publikováno v:
PLoS ONE, Vol 19, Iss 9, p e0301181 (2024)
Advancements in veterinary medicine have resulted in increased life spans for dogs, necessitating a better understanding of quality of life for older dogs. This study aimed to evaluate quality of life (QoL) progression and its potential association w
Externí odkaz:
https://doaj.org/article/6963d076ea6149b48a2cc6c4796816f9
Autor:
Alejandra Mondino, Michael Khan, Beth Case, Sara Giovagnoli, Andrea Thomson, B. Duncan X. Lascelles, Margaret Gruen, Natasha Olby
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Maintaining an active lifestyle is considered a hallmark of successful aging. Physical activity significantly reduces the risk of cognitive decline and Alzheimer’s disease in humans. However, pain and lack of motivation are important barri
Externí odkaz:
https://doaj.org/article/d0182de72f9d4576912676e9532792af
Autor:
Michael Z. Khan, Alejandra Mondino, Katharine Russell, Beth Case, Gilad Fefer, Hope Woods, Natasha Olby, Margaret Gruen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract While much work has been done in the field of canine olfaction, there has been little exploration of hyposmia or anosmia. This is partly due to difficulties in reducing confounds like training history and environmental distraction. The curre
Externí odkaz:
https://doaj.org/article/f2eccc30404b4ea3967a1f7ceedc1037
Autor:
Alejandra Mondino, Michael Khan, Beth Case, Gilad Fefer, Wojciech K. Panek, Margaret E. Gruen, Natasha J. Olby
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
IntroductionIn humans, gait speed is a crucial component in geriatric evaluation since decreasing speed can be a harbinger of cognitive decline and dementia. Aging companion dogs can suffer from age-related mobility impairment, cognitive decline and
Externí odkaz:
https://doaj.org/article/a269767f50b24757a41ac2fc1b640112
Autor:
Alejandra Mondino, Magaly Catanzariti, Diego Martin Mateos, Michael Khan, Claire Ludwig, Anna Kis, Margaret E. Gruen, Natasha J. Olby
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
IntroductionSleep is fundamental for cognitive homeostasis, especially in senior populations since clearance of amyloid beta (key in the pathophysiology of Alzheimer's disease) occurs during sleep. Some electroencephalographic characteristics of slee
Externí odkaz:
https://doaj.org/article/c1d1c6a7838641b7b7ba4f6e5ea9476a
Autor:
Michael Z. Khan, Alejandra Mondino, Katharine Russell, Beth Case, Gilad Fefer, Hope Woods, Natasha J. Olby, Margaret E. Gruen
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2023)
IntroductionThe aim of this study was to evaluate the engagement of aging dogs with a cognitively challenging and potentially frustrating task (the impossible task). Based on previous observations, we predicted that dogs showing signs of cognitive im
Externí odkaz:
https://doaj.org/article/54a291280514443a90a702ae5a31eed4
Autor:
Claudia Pascovich, Sofia Niño, Alejandra Mondino, Ximena Lopez-Hill, Jessika Urbanavicius, Jaime Monti, Patricia Lagos, Pablo Torterolo
Publikováno v:
Sleep Science, Vol 14, Iss 3, Pp 229-235 (2021)
Melanin concentrating hormone (MCH) is a sleep-promoting neuromodulator synthesized by neurons located in the postero-lateral hypothalamus and incerto-hypothalamic area. MCHergic neurons have widespread projections including the serotonergic dorsal (
Externí odkaz:
https://doaj.org/article/c312142cb743488b92e93c714fd1206c
Autor:
Alejandra Mondino, Matías Cavelli, Joaquín González, Lucía Osorio, Santiago Castro-Zaballa, Alicia Costa, Giancarlo Vanini, Pablo Torterolo
Publikováno v:
Clocks & Sleep, Vol 2, Iss 4, Pp 536-556 (2020)
The sleep-wake cycle is constituted by three behavioral states: wakefulness (W), non-REM (NREM) and REM sleep. These states are associated with drastic changes in cognitive capacities, mostly determined by the function of the thalamo-cortical system,
Externí odkaz:
https://doaj.org/article/e27b42455737405fa37972416e70204c