The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts

Autor: Aleix Bayona-Feliu, Emilia Herrera-Moyano, Nibal Badra-Fajardo, Iván Galván-Femenía, María Eugenia Soler-Oliva, Andrés Aguilera

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large part associated with R-loops, which hamper replication, especially at head-on transcription-replication conflicts (TRCs)

Externí odkaz: https://doaj.org/article/813890087e994b3387dab47b526b0ac3

TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage.

Autor: Marta Giannini, Aleix Bayona-Feliu, Daisy Sproviero, Sonia I Barroso, Cristina Cereda, Andrés Aguilera

Publikováno v: PLoS Genetics, Vol 16, Iss 12, p e1009260 (2020)

TDP-43 is a DNA and RNA binding protein involved in RNA processing and with structural resemblance to heterogeneous ribonucleoproteins (hnRNPs), whose depletion sensitizes neurons to double strand DNA breaks (DSBs). Amyotrophic Lateral Sclerosis (ALS

Externí odkaz: https://doaj.org/article/d695da3ae0b64c96911d89211d59eced

The role of chromatin at transcription-replication conflicts as a genome safeguard

Autor: Andrés Aguilera, Aleix Bayona-Feliu

Publikováno v: Biochemical Society Transactions
idUS. Depósito de Investigación de la Universidad de Sevilla
instname

DNA replication ensures the correct copying of the genome and the faithful transfer of the genetic information to the offspring. However, obstacles to replication fork (RF) progression cause RF stalling and compromise efficient genome duplication. Si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb32c91fc415cd2b20112c2bd543467
https://doi.org/10.1042/bst20210691

Corrigendum: UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide

Autor: Xiaoyu Xue, Aleix Bayona-Feliu, Víctor M. González-Basallote, Sonia Barroso, Andrés Aguilera, Carmen Pérez-Calero, Patrick Sung, Sergio Muñoz

Publikováno v: Genes Dev

Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent R-loop accumulation. One mechanism relies on the conserved THO complex in association with cotranscriptional RNA processing facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c43b9e8388ea330a332a20c4e2924de
https://europepmc.org/articles/PMC8015723/

TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loopmediated DNA damage

Autor: Marta Gianini, Cristina Cereda, Daisy Sproviero, Sonia Barroso, Aleix Bayona-Feliu, Andrés Aguilera

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
PLoS Genetics, Vol 16, Iss 12, p e1009260 (2020)
idUS. Depósito de Investigación de la Universidad de Sevilla
PLoS Genetics
PLOS Genetics

TDP-43 is a DNA and RNA binding protein involved in RNA processing and with structural resemblance to heterogeneous ribonucleoproteins (hnRNPs), whose depletion sensitizes neurons to double strand DNA breaks (DSBs). Amyotrophic Lateral Sclerosis (ALS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d56a3bc7ce25d270d96e04a02703bce
http://hdl.handle.net/10261/228270