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Akademický článek

NEAT1 modulates the TIRR/53BP1 complex to maintain genome integrity

Autor: Susan Kilgas, Aleem Syed, Patrick Toolan-Kerr, Michelle L. Swift, Shrabasti Roychoudhury, Aniruddha Sarkar, Sarah Wilkins, Mikayla Quigley, Anna R. Poetsch, Maria Victoria Botuyan, Gaofeng Cui, Georges Mer, Jernej Ule, Pascal Drané, Dipanjan Chowdhury

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Tudor Interacting Repair Regulator (TIRR) is an RNA-binding protein (RBP) that interacts directly with 53BP1, restricting its access to DNA double-strand breaks (DSBs) and its association with p53. We utilized iCLIP to identify RNAs that dir

Externí odkaz: https://doaj.org/article/a3262ed44e984be894b2ab228e2c52d3

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Akademický článek

Automating data analysis for hydrogen/deuterium exchange mass spectrometry using data-independent acquisition methodology

Autor: Frantisek Filandr, Vladimir Sarpe, Shaunak Raval, D. Alex Crowder, Morgan F. Khan, Pauline Douglas, Stephen Coales, Rosa Viner, Aleem Syed, John A. Tainer, Susan P. Lees-Miller, David C. Schriemer

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract We present a hydrogen/deuterium exchange workflow coupled to tandem mass spectrometry (HX-MS2) that supports the acquisition of peptide fragment ions alongside their peptide precursors. The approach enables true auto-curation of HX data by m

Externí odkaz: https://doaj.org/article/8c900839ad1c4b10a419586ee7d79785

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Akademický článek

Author Correction: Automating data analysis for hydrogen/deuterium exchange mass spectrometry using data-independent acquisition methodology

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)

Externí odkaz: https://doaj.org/article/165f5b3a8f494e12ab6cbfdea6535412

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Akademický článek

Charge Transport Communication through DNA by Protein Fe–S Clusters: How Far Is Not Too Far?

Autor: Aleem Syed, John A. Tainer

Publikováno v: ACS Central Science, Vol 5, Iss 1, Pp 7-9 (2019)

Externí odkaz: https://doaj.org/article/b9530883310c42ed9e72ff81e9a7b969

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Dynamics of the DYNLL1/MRE11 complex regulates DNA end resection and recruitment of the Shieldin complex to DSBs

Autor: Rui Zhou, Michelle L. Swift, Aleem Syed, Kaimeng Huang, Lisa Moreau, John A. Tainer, Panagiotis A. Konstantinopoulos, Alan D. D’Andrea, Yizhou Joseph He, Dipanjan Chowdhury

Publikováno v: bioRxiv

Extent and efficacy of DNA end resection at DNA double strand break (DSB)s determines the choice of repair pathway. Here we describe how the 53BP1 associated protein DYNLL1 works in tandem with Shieldin and the CST complex to protect DNA ends. DYNLL1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0a3f67fee7a6bd797dce5775b4d0be
https://doi.org/10.1101/2023.03.27.534416

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Akademický článek

Research Avenues on use of Augmented Reality in Education.

Autor: Sapkal, Laxmi, Aleem, Syed

Publikováno v: Acta Graphica; Oct2023, Vol. 31 Issue 2, p63-74, 12p

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Combining small angle X-ray scattering (SAXS) with protein structure predictions to characterize conformations in solution

Autor: Naga Babu Chinnam, Aleem Syed, Greg L. Hura, Michal Hammel, John A. Tainer, Susan E. Tsutakawa

Publikováno v: Small Angle Scattering Part B: Methods for Structural Interpretation ISBN: 9780323991810

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e10fb39f3394c1521c3d19a0735556e
https://doi.org/10.1016/bs.mie.2022.09.023

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Universally Accessible Structural Data on Macromolecular Conformation, Assembly, and Dynamics by Small Angle X-Ray Scattering for DNA Repair Insights

Autor: Naga Babu Chinnam, Aleem Syed, Kathryn H. Burnett, Greg L. Hura, John A. Tainer, Susan E. Tsutakawa

Publikováno v: Methods Mol Biol
Methods in Molecular Biology ISBN: 9781071620625

Structures provide a critical breakthrough step for biological analyses, and Small Angle X-ray Scattering (SAXS) is a powerful structural technique to study dynamic DNA repair proteins. As toxic and mutagenic repair intermediates need to be prevented

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531030f8007ef9c4fb891b0db32947c6
https://pubmed.ncbi.nlm.nih.gov/35290631

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Monitoring Nuclease Activity by X-Ray Scattering Interferometry Using Gold Nanoparticle-Conjugated DNA

Autor: Daniel J. Rosenberg, Aleem Syed, John A. Tainer, Greg L. Hura

Publikováno v: Methods Mol Biol
Methods in Molecular Biology ISBN: 9781071620625

The biologically critical, exquisite specificity and efficiency of nucleases, such as those acting in DNA repair and replication, often emerge in the context of multiple other macromolecules. The evolved complexity also makes biologically relevant nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd2db148f0944cd294e4db763caee47
https://pubmed.ncbi.nlm.nih.gov/35290639

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