Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Aled M Edwards"'
Autor:
Riham Ayoubi, Joel Ryan, Michael S Biddle, Walaa Alshafie, Maryam Fotouhi, Sara Gonzalez Bolivar, Vera Ruiz Moleon, Peter Eckmann, Donovan Worrall, Ian McDowell, Kathleen Southern, Wolfgang Reintsch, Thomas M Durcan, Claire Brown, Anita Bandrowski, Harvinder Virk, Aled M Edwards, Peter McPherson, Carl Laflamme
Publikováno v:
eLife, Vol 12 (2023)
Antibodies are critical reagents to detect and characterize proteins. It is commonly understood that many commercial antibodies do not recognize their intended targets, but information on the scope of the problem remains largely anecdotal, and as suc
Externí odkaz:
https://doaj.org/article/bac269b88e3b4d2f897fb9ef14c58a24
Autor:
Carl Laflamme, Paul M McKeever, Rahul Kumar, Julie Schwartz, Mahshad Kolahdouzan, Carol X Chen, Zhipeng You, Faiza Benaliouad, Opher Gileadi, Heidi M McBride, Thomas M Durcan, Aled M Edwards, Luke M Healy, Janice Robertson, Peter S McPherson
Publikováno v:
eLife, Vol 8 (2019)
Antibodies are a key resource in biomedical research yet there are no community-accepted standards to rigorously characterize their quality. Here we develop a procedure to validate pre-existing antibodies. Human cell lines with high expression of a t
Externí odkaz:
https://doaj.org/article/5dd99f539d7743e5b6734eaf3c37ed67
Autor:
Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jon M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart MJ Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia YI Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, Anke Mueller-Fahrnow
Publikováno v:
eLife, Vol 7 (2018)
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been mad
Externí odkaz:
https://doaj.org/article/959198e7fd31440495c0d4c7cf3c5c06
Autor:
Kristina Edfeldt, Aled M. Edwards, Ola Engkvist, Judith Günther, Matthew Hartley, David G. Hulcoop, Andrew R. Leach, Brian D. Marsden, Amelie Menge, Leonie Misquitta, Susanne Müller, Dafydd R. Owen, Kristof T. Schütt, Nicholas Skelton, Andreas Steffen, Alexander Tropsha, Erik Vernet, Yanli Wang, James Wellnitz, Timothy M. Willson, Djork-Arné Clevert, Benjamin Haibe-Kains, Lovisa Holmberg Schiavone, Matthieu Schapira
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The Structural Genomics Consortium is an international open science research organization with a focus on accelerating early-stage drug discovery, namely hit discovery and optimization. We, as many others, believe that artificial intelligenc
Externí odkaz:
https://doaj.org/article/d7b4037ed6df47b49327448e7112d3fb
Autor:
Nan Zhong, Peter Loppnau, Alma Seitova, Mani Ravichandran, Maria Fenner, Harshika Jain, Anandi Bhattacharya, Ashley Hutchinson, Marcin Paduch, Vincent Lu, Michal Olszewski, Anthony A Kossiakoff, Evan Dowdell, Akiko Koide, Shohei Koide, Haiming Huang, Vincent Nadeem, Sachdev S Sidhu, Jack F Greenblatt, Edyta Marcon, Cheryl H Arrowsmith, Aled M Edwards, Susanne Gräslund
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139695 (2015)
We developed and optimized a high-throughput project workflow to generate renewable recombinant antibodies to human proteins involved in epigenetic signalling. Three different strategies to produce phage display compatible protein antigens in bacteri
Externí odkaz:
https://doaj.org/article/dd18dddf47c540eb9b460223ee62eb80
Autor:
Rachel J. Harding, Carl Laflamme, Sara González Bolívar, Aled M. Edwards, Kathleen Southern, Rebeka Fanti, Riham Ayoubi, Charles Alende, Maryam Fotouhi, Renu Chandrasekaran
Publikováno v:
F1000Research, Vol 13 (2024)
Huntingtin encodes a 3144 amino acid protein, with a polyglutamine repeat tract at the N-terminus. Expansion of this repeat tract above a pathogenic threshold of 36 repeats is the causative mutation of Huntington's disease, a neurodegenerative disord
Externí odkaz:
https://doaj.org/article/4a5893b8570c4bb6a47f872075702b74
Publikováno v:
F1000Research, Vol 12 (2024)
Midkine is a secreted protein that acts as a growth factor or cytokine involved in cell survival and inflammatory processes. It accumulates in amyloid plaques, which are hallmarks of Alzheimer’s Disease (AD). The reproducibility of Midkine research
Externí odkaz:
https://doaj.org/article/c30ab8b2fbfe4f2092198a5d29419ef1
Publikováno v:
F1000Research, Vol 12 (2024)
Midkine is a secreted protein that acts as a growth factor or cytokine involved in cell survival and inflammatory processes. It accumulates in amyloid plaques, which are hallmarks of Alzheimer’s Disease (AD). The reproducibility of Midkine research
Externí odkaz:
https://doaj.org/article/a1e0ee004b4d4ea5808c172a1f070154
Autor:
Hassan Masum, Aarthi Rao, Benjamin M Good, Matthew H Todd, Aled M Edwards, Leslie Chan, Barry A Bunin, Andrew I Su, Zakir Thomas, Philip E Bourne
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 9, p e1003244 (2013)
Externí odkaz:
https://doaj.org/article/c9056ebb0aed481caca10f22cb490625
Autor:
Abdellah Allali-Hassani, Patricia W Pan, Ludmila Dombrovski, Rafael Najmanovich, Wolfram Tempel, Aiping Dong, Peter Loppnau, Fernando Martin, Janet Thornton, Aled M Edwards, Alexey Bochkarev, Alexander N Plotnikov, Masoud Vedadi, Cheryl H Arrowsmith
Publikováno v:
PLoS Biology, Vol 5, Iss 5, p e97 (2007)
The human cytosolic sulfotransfases (hSULTs) comprise a family of 12 phase II enzymes involved in the metabolism of drugs and hormones, the bioactivation of carcinogens, and the detoxification of xenobiotics. Knowledge of the structural and mechanist
Externí odkaz:
https://doaj.org/article/b16aa60a578740d2ac8dcb3a1c09342a