Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Aleck, Hercbergs"'
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
The principal hormonal product of the thyroid gland, L-thyroxine (T4), is a prohormone for 3,3’,5-triiodo-L-thyronine, T3, the major ligand of nuclear thyroid hormone receptors (TRs). At a cell surface thyroid hormone analogue receptor on cancer ce
Externí odkaz:
https://doaj.org/article/6ce095d67c444bdb857b3b589c038141
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
Thyroid hormone as L-thyroxine (T4) acts nongenomically at physiological concentrations at its cancer cell surface receptor on integrin αvβ3 (‘thyrointegrin’) to cause cancer cell proliferation. In the case of estrogen receptor (ERα)-positive
Externí odkaz:
https://doaj.org/article/fa616116676b4194aa1c9e0a4ffda641
Autor:
Yi-Fong Chen, Yung-Ning Yang, Hung-Ru Chu, Tung-Yung Huang, Shwu-Huey Wang, Han-Yu Chen, Zi-Lin Li, Yu-Chen S. H. Yang, Hung-Yun Lin, Aleck Hercbergs, Jacqueline Whang-Peng, Kuan Wang, Paul J. Davis
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Doxycycline, an antibiotic, displays the inhibition of different signal transduction pathways, such as anti-inflammation and anti-proliferation, in different types of cancers. However, the anti-cancer mechanisms of doxycycline via integrin αvβ3 are
Externí odkaz:
https://doaj.org/article/7e367beb7ba04f0dad4122e0b54844c9
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
L-Thyroxine (T4) is the principal ligand of the thyroid hormone analogue receptor on the extracellular domain of integrin αvβ3. The integrin is overexpressed and activated in cancer cells, rapidly dividing endothelial cells, and platelets. The biol
Externí odkaz:
https://doaj.org/article/eceb36dab1ba449887e9049ac55e8ede
Autor:
Elena Shinderman-Maman, Keren Cohen, Dotan Moskovich, Aleck Hercbergs, Haim Werner, Paul J. Davis, Martin Ellis, Osnat Ashur-Fabian
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Ovarian cancer is a highly aggressive disease and novel treatments are required. Thyroid hormones binding to αvβ3 integrin produced growth-promoting activities in ovarian cancer and we hypothesized that natural thyroid hormone derivatives
Externí odkaz:
https://doaj.org/article/0387e756b4e9437087dee0edd92fdf52
Autor:
Aleck Hercbergs
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Hypothyroidism has been reported to improve survival in cancer patients but only recently has the putative mechanism been identified as a receptor for thyroxine and tri-iodothyronine on integrin αvβ3. Recognition of divergence of action of the pro-
Externí odkaz:
https://doaj.org/article/b3c8f02dc9ec4dc88a68b67249eb4ab5
Autor:
Osnat Ashur-Fabian, Ofira Zloto, Ina Fabian, Galya Tsarfaty, Martin Ellis, David M. Steinberg, Aleck Hercbergs, Paul J. Davis, Ido Didi Fabian
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2019)
Ocular melanoma research, the most common primary intraocular malignancy in adults, is hindered by limited in vivo models. In a series of experiments using melanoma cells injected intraocularly into mouse eyes, we developed a model for ocular melanom
Externí odkaz:
https://doaj.org/article/c4ff66d8c47947e8840623e6b27f7988
PDF file - 77K, Real-time PCR primers for apoptotic genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2a1150a2d55a23bd39fb5bd513fa79
https://doi.org/10.1158/1541-7786.22519273
https://doi.org/10.1158/1541-7786.22519273
Autor:
Paul J. Davis, Heng-Yuan Tang, Aleck Hercbergs, Hung-Yun Lin, Kelly A. Keating, Shaker A. Mousa
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
In the context of genomic thyroid hormone actions in normal (noncancer) cells that involve primary interactions with nuclear thyroid hormone receptors (TRs), L-thyroxine (T4), and 3,3′,5′-triiodo-L-thyronine (reverse T3, rT3) have little bioactiv
Externí odkaz:
https://doaj.org/article/dba30e9c711e43fcbc6dbc1d9a39b863
Publikováno v:
Endocrine Research. 47:39-44
Background Integrin αvβ3 is a cell membrane structural protein whose extracellular domain contains a receptor for L-thyroxine (T4). The integrin is expressed in rapidly dividing cells and its internalization is prompted by T4. The protein binds vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ea22fe7432483136d3b15739558c26
https://doi.org/10.1080/07435800.2021.1972307
https://doi.org/10.1080/07435800.2021.1972307