Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Alecia K"'
Autor:
Roly Megaw, Abigail Moye, Zhixian Zhang, Fay Newton, Fraser McPhie, Laura C. Murphy, Lisa McKie, Feng He, Melissa K. Jungnickel, Alex von Kriegsheim, Peter A. Tennant, Chloe Brotherton, Christine Gurniak, Alecia K. Gross, Laura M. Machesky, Theodore G. Wensel, Pleasantine Mill
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract As signalling organelles, cilia regulate their G protein-coupled receptor content by ectocytosis, a process requiring localised actin dynamics to alter membrane shape. Photoreceptor outer segments comprise an expanse of folded membranes (dis
Externí odkaz:
https://doaj.org/article/162f25833a9b438992ccafbff79b3556
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-11 (2023)
Abstract Background Recently approved treatments for spinal muscular atrophy (SMA) may shift clinical care priorities to secondary complications associated with SMA-related aging. To date, there is little knowledge about the natural history of morbid
Externí odkaz:
https://doaj.org/article/6f27f4f013cf4a5a80df697c8d89592b
Publikováno v:
Frontiers in Ophthalmology, Vol 2 (2022)
The maintenance of intraocular pressure (IOP) is critical to preserving the pristine optics required for vision. Disturbances in IOP can directly impact the optic nerve and retina, and inner retinal injury can occur following acute and chronic IOP el
Externí odkaz:
https://doaj.org/article/5a84dd9cc19e4bff91ede5c12bafac92
Autor:
T.J. Hollingsworth, Meredith G. Hubbard, Hailey J. Levi, William White, Xiangdi Wang, Raven Simpson, Monica M. Jablonski, Alecia K. Gross
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1163 (2021)
Retinitis pigmentosa (RP) is a hereditary disease of the retina that results in complete blindness. Currently, there are very few treatments for the disease and those that exist work only for the recessively inherited forms. To better understand the
Externí odkaz:
https://doaj.org/article/51222d457ee84673bc4a2aceedf7499d
Autor:
T.J. Hollingsworth, Alecia K. Gross
Publikováno v:
Cells, Vol 9, Iss 3, p 630 (2020)
Inherited retinal dystrophies (RDs) are heterogenous in many aspects including genes involved, age of onset, rate of progression, and treatments. While RDs are caused by a plethora of different mutations, all result in the same outcome of blindness.
Externí odkaz:
https://doaj.org/article/380a9f6648ca40378229aa6e90201405
Autor:
Diep K. Hoang Johnson, Elizabeth Schiffman, Jeffrey P. Davis, David Neitzel, Lynne M. Sloan, William L. Nicholson, Thomas R. Fritsche, Christopher R. Steward, Julie A. Ray, Tracy K. Miller, Michelle A. Feist, Timothy S. Uphoff, Joni J. Franson, Amy L. Livermore, Alecia K. Deedon, Elitza S. Theel, Bobbi Pritt
Publikováno v:
Emerging Infectious Diseases, Vol 21, Iss 10, Pp 1794-1799 (2015)
An Ehrlichia muris–like (EML) pathogen was detected among 4 patients in Minnesota and Wisconsin during 2009. We characterized additional cases clinically and epidemiologically. During 2004–2013, blood samples from 75,077 patients from all 50 Unit
Externí odkaz:
https://doaj.org/article/d89823e2b7fb438fb5fb3cc720f8eb22
Autor:
Anil K Challa, Evan R Boitet, Ashley N Turner, Larry W Johnson, Daniel Kennedy, Ethan R Downs, Katherine M Hymel, Alecia K Gross, Robert A Kesterson
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155812 (2016)
Tyrosinase is a key enzyme in melanin biosynthesis. Mutations in the gene encoding tyrosinase (Tyr) cause oculocutaneous albinism (OCA1) in humans. Alleles of the Tyr gene have been useful in studying pigment biology and coat color formation. Over 10
Externí odkaz:
https://doaj.org/article/95612f7154c0442c904d4ddc71281093
Autor:
Ivette M Sandoval, Brandee A Price, Alecia K Gross, Fung Chan, Joshua D Sammons, John H Wilson, Theodore G Wensel
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108135 (2014)
For sensitive detection of rare gene repair events in terminally differentiated photoreceptors, we generated a knockin mouse model by replacing one mouse rhodopsin allele with a form of the human rhodopsin gene that causes a severe, early-onset form
Externí odkaz:
https://doaj.org/article/16baeec528b947bb922a3c037c30319e
Autor:
Girkin, Christopher A., Strickland, Ryan G., Somerville, McKenna M., Garner, Mary Anne, Grossman, Gregory H., Blake, Alan, Kumar, Nilesh, Ianov, Lara, Fazio, Massimo A., Clark, Mark E., Gross, Alecia K.
Publikováno v:
In Vision Research October 2024 223
Autor:
Girkin, Christopher A., Garner, Mary Anne, Fazio, Massimo A., Clark, Mark E., Karuppanan, Udayakumar, Hubbard, Meredith G., Bianco, Gianfranco, Hubbard, Seth T., Fortune, Brad, Gross, Alecia K.
Publikováno v:
In Experimental Eye Research April 2023 229