Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alec T Salminen"'
Autor:
Elysia A Masters, Karen L de Mesy Bentley, Ann Lindley Gill, Stephanie P Hao, Chad A Galloway, Alec T Salminen, Diamond R Guy, James L McGrath, Hani A Awad, Steven R Gill, Edward M Schwarz
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008988 (2020)
Staphylococcus aureus infection of bone is challenging to treat because it colonizes the osteocyte lacuno-canalicular network (OLCN) of cortical bone. To elucidate factors involved in OLCN invasion and identify novel drug targets, we completed a hypo
Externí odkaz:
https://doaj.org/article/7af9131daa684b63b6a98dd659fd5493
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
A functional human skin barrier is critical in limiting harmful exposure to environmental agents and regulating the absorption of intentionally applied topical drug and cosmetic products. Inherent differences in the skin barrier between consumers due
Externí odkaz:
https://doaj.org/article/e8ea117500b448aa9baa101571d74bb4
Autor:
Michael E. Klaczko, Kilean Lucas, Alec T. Salminen, Molly C. McCloskey, Baturay Ozgurun, Brian M. Ward, Jonathan Flax, James L. McGrath
Publikováno v:
The Analyst. 147:213-222
The COVID-19 pandemic demonstrated the public health benefits of reliable and accessible point-of-care (POC) diagnostic tests for viral infections. Despite the rapid development of gold-standard reverse transcription polymerase chain reaction (RT-PCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd771814d99f9eaa0c9116488d97597
https://doi.org/10.1039/d1an01504d
https://doi.org/10.1039/d1an01504d
Autor:
Alec T. Salminen, Molly C. McCloskey, S. Danial Ahmad, Samantha S. Romanick, Kaihua Chen, William Houlihan, Michael E. Klaczko, Jonathan Flax, Richard E. Waugh, James L. McGrath
Publikováno v:
European Journal of Cell Biology. 101:151233
Sphingosine-1-phosphate (S1P) signals to enhance or destabilize the vascular endothelial barrier depending on the receptor engaged. Here, we investigated the differential barrier effects of S1P on two influential primary endothelial cell (EC) types,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41478e5806755378a88762b0f386b833
https://doi.org/10.1016/j.ejcb.2022.151233
https://doi.org/10.1016/j.ejcb.2022.151233
Autor:
Thomas R. Gaborski, Zahra Allahyari, Alec T. Salminen, Renee N. Cottle, Molly C McCloskey, Shayan Gholizadeh, James L. McGrath, Raquel E Ajalik
Publikováno v:
Frontiers in Medical Technology
Inflammatory diseases and cancer metastases lack concrete pharmaceuticals for their effective treatment despite great strides in advancing our understanding of disease progression. One feature of these disease pathogeneses that remains to be fully ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1491b68bbd68e3b9b3ae9c3873c9e6a4
https://doi.org/10.3389/fmedt.2020.600616
https://doi.org/10.3389/fmedt.2020.600616
Autor:
Diamond R. Guy, James L. McGrath, Edward M. Schwarz, Alec T. Salminen, Hani A. Awad, Elysia A Masters, Stephanie P. Hao, Steven R. Gill, Karen L. de Mesy Bentley, Ann L. Gill, Chad A. Galloway
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 10, p e1008988 (2020)
PLoS Pathogens, Vol 16, Iss 10, p e1008988 (2020)
Staphylococcus aureus infection of bone is challenging to treat because it colonizes the osteocyte lacuno-canalicular network (OLCN) of cortical bone. To elucidate factors involved in OLCN invasion and identify novel drug targets, we completed a hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf334978ff9f8a7a6d70d50b03c32b1
http://europepmc.org/articles/PMC7608983
http://europepmc.org/articles/PMC7608983
Autor:
Alec T. Salminen, Anthony P. Pietropaoli, Douglas H. Kelley, Molly C McCloskey, Richard E. Waugh, Elysia A Masters, Thomas R. Gaborski, Jeffrey Tithof, James L. McGrath, Yara Izhiman
Publikováno v:
Integr Biol (Camb)
Endothelial cells (ECs) are an active component of the immune system and interact directly with inflammatory cytokines. While ECs are known to be polarized cells, the potential role of apicobasal polarity in response to inflammatory mediators has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69bb8f6e56835a43d58dd7982b87373
https://pubmed.ncbi.nlm.nih.gov/33164044
https://pubmed.ncbi.nlm.nih.gov/33164044
Publikováno v:
International Journal of Toxicology. 36:365-379
Drug-induced liver injury in children (cDILI) accounts for about 1% of all reported adverse drug reactions throughout all age groups, less than 10% of all clinical DILI cases, and around 20% of all acute liver failure cases in children. The overall D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a538f0678c80a2443bbbfc2d9bd6ac
https://doi.org/10.1177/1091581817721675
https://doi.org/10.1177/1091581817721675
Autor:
Alec T. Salminen, William B. Mattes, William F. Salminen, Thomas Papoian, Lijun Ren, Yong Luo, Matthew White, Xi Yang, Qiangen Wu, Qiang Shi, Jun Zhang, Matthew Bryant, James Greenhaw
Publikováno v:
Archives of Toxicology
The FDA has approved 31 small-molecule kinase inhibitors (KIs) for human use as of November 2016, with six having black box warnings for hepatotoxicity (BBW-H) in product labeling. The precise mechanisms and risk factors for KI-induced hepatotoxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0ad385e4eaca817ad52a8e18a1e0f3
http://europepmc.org/articles/PMC5515969
http://europepmc.org/articles/PMC5515969
Autor:
James L. McGrath, Alec T. Salminen, Raquel E Ajalik, Angela Glading, Molly C McCloskey, Thomas R. Gaborski, Kilean Lucas, Henry H. Chung, Richard E. Waugh, Harsha Swamy, Tejas S. Khire
Publikováno v:
Cell Mol Bioeng
INTRODUCTION: The pathophysiological increase in microvascular permeability plays a well-known role in the onset and progression of diseases like sepsis and atherosclerosis. However, how interactions between neutrophils and the endothelium alter vess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1aa740821c26edc450b3cae5e3b9d37
https://pubmed.ncbi.nlm.nih.gov/32175026
https://pubmed.ncbi.nlm.nih.gov/32175026