Spontaneously evolved progenitor niches escape Yap oncogene addiction in advanced pancreatic ductal adenocarcinomas

Autor: Shigekazu Murakami, Shannon M. White, Alec T. McIntosh, Chan D. K. Nguyen, Chunling Yi

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

It remains unclear how spontaneous Pancreatic Ductal Adenocarcinoma (PDAC) tumors escape Yap dependency. Here, the authors show that lineage plasticity promotes spontaneous relapse following YAP ablation and reveal key transcriptional drivers that ov

Externí odkaz: https://doaj.org/article/df63191ad5df4c8da8cf9519ea7988c1

miR614 Expression Enhances Breast Cancer Cell Motility

Autor: Julio C. Morales, Alec T. McIntosh, Gray W. Pearson, Tuyen T. Dang

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 112, p 112 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 1; Pages: 112
International Journal of Molecular Sciences

Using a data driven analysis of a high-content screen, we have uncovered new regulators of epithelial-to-mesenchymal transition (EMT) induced cell migration. Our results suggest that increased expression of miR614 can alter cell intrinsic gene expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b3093687dbde40dff9693385b2a21e
https://www.mdpi.com/1422-0067/22/1/112

A genomic variant of ALPK2 is associated with increased liver fibrosis risk in HIV/HCV coinfected women

Autor: Michael Augenbraun, Kathryn Anastos, Jennifer C. Price, Audrey L. French, Renhuizi Wei, Radoslav Goldman, Jaeil Ahn, Stephen J. Gange, Brad E. Aouizerat, Alec T. McIntosh, Seble Kassaye

Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0247277 (2021)

HIV coinfection is associated with more rapid liver fibrosis progression in hepatitis C (HCV) infection. Recently, much work has been done to improve outcomes of liver disease and to identify targets for pharmacological intervention in coinfected pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03673c57fdc69cd04f547642592b2d7c
https://pubmed.ncbi.nlm.nih.gov/33705408

Close yet so far away: a look into the management strategies of genetic imprinting disorders

Autor: Mark A, Pianka, Alec T, McIntosh, Sahaj D, Patel, Pegah R, Bakhshi, Mira, Jung

Publikováno v: American journal of stem cells. 7(4)

Genetic imprinting is the process of epigenetic labelling or silencing of particular genes, based on the maternal or paternal origin of the gene, in a heritable pattern. The incidence of imprinting disorders has become a growing concern due to the po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dca8183d66421c8c43f1425b0c3d75c5
https://pubmed.ncbi.nlm.nih.gov/30510842