Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Alec S.T. Smith"'
Publikováno v:
Brain Multiphysics, Vol 3, Iss , Pp 100054- (2022)
During protein synthesis, aminoacyl-tRNA synthetases covalently link amino acids with their cognate tRNAs. Amino acid mutations in glycyl-tRNA synthetase can disrupt protein synthesis and lead to a neurological disorder known as Charcot-Marie-Tooth d
Externí odkaz:
https://doaj.org/article/692267c55c98424db67483c287042e74
Neuroinflammation is an established factor contributing to amyotrophic lateral sclerosis (ALS) pathology, implicating the possible detrimental effects of inflammatory cytokines on motor neurons. The RNA/DNA-binding protein TDP-43 has emerged as a piv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb2c056886cfdd6dcf6a7d36d2d9c061
https://doi.org/10.1101/2022.11.18.517141
https://doi.org/10.1101/2022.11.18.517141
Publikováno v:
Muscle & Nerve. 64:388-403
Recent development of novel therapies has improved mobility and quality of life for people suffering from inheritable neuromuscular disorders. Despite this progress, the majority of neuromuscular disorders are still incurable, in part due to a lack o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464bc8a94f77055cdce33d2663728e5a
https://doi.org/10.1002/mus.27360
https://doi.org/10.1002/mus.27360
Autor:
Nisa P. Williams, Kevin M. Beussman, John R. Foster, Marcus Rhodehamel, Charles A. Williams, Jonathan H. Tsui, Alec S.T. Smith, David L. Mack, Charles E. Murry, Nathan J. Sniadecki, Deok-Ho Kim
Tissue engineering with human induced pluripotent stem cell-derived cardiomyocytes enables unique opportunities for creating physiological models of the heart in vitro. However, there are few approaches available that can recapitulate the complex str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ded9cb61b22aa053fe7c3ef2113d779
https://doi.org/10.1101/2022.08.18.504345
https://doi.org/10.1101/2022.08.18.504345
Autor:
Christian Mandrycky, Saffie Mohran, Matthew C. Childers, Alec S.T. Smith, Michael Regnier, David L. Mack
Publikováno v:
Biophysical Journal. 122:149a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::113777e82950e08ed3bd6c5fd8a05d45
https://doi.org/10.1016/j.bpj.2022.11.1018
https://doi.org/10.1016/j.bpj.2022.11.1018
Autor:
Michael A. Laflamme, Joseph C. Wu, Charles E. Murry, Kevin Gray, Eunpyo Choi, Alec S.T. Smith, Elisa C. Clark, Deok Ho Kim, Leslie Tung, Jesse Macadangdang, Eun Hyun Ahn
Publikováno v:
Nano Lett
Matrix nanotopographical cues are known to regulate the structure and function of somatic cells derived from human pluripotent stem cell (hPSC) sources. High-throughput electrophysiological analysis of excitable cells derived from hPSCs is possible v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b956495d43a3afad2d02b189b8daf1
https://doi.org/10.1021/acs.nanolett.9b04152
https://doi.org/10.1021/acs.nanolett.9b04152
Autor:
Alec S.T. Smith, Jong Hyun Kim, Changho Chun, Ava Gharai, Hyo Won Moon, Eun Young Kim, Soo Hyun Nam, Nina Ha, Ju Young Song, Ki Wha Chung, Hyun Myung Doo, Jennifer Hesson, Julie Mathieu, Mark Bothwell, Byung‐Ok Choi, Deok‐Ho Kim
Publikováno v:
Adv Biol (Weinh)
Charcot-Marie-Tooth disease type 2D (CMT2D), is a hereditary peripheral neuropathy caused by mutations in the gene encoding glycyl-tRNA synthetase (GARS1). Here, human induced pluripotent stem cell (hiPSC)-based models of CMT2D bearing mutations in G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3bb5b8a8e38b16446873b0a0ca4cba
https://europepmc.org/articles/PMC8849597/
https://europepmc.org/articles/PMC8849597/
Autor:
Shiri Levy, Yuliang Wang, Andrea Leonard, Hannele Ruohola-Baker, Elisa C. Clark, Tuula Manninen, Kevin M. Beussman, Jason W. Miklas, Deok Ho Kim, Oliver Fiehn, Nathan J. Sniadecki, Charles E. Murry, Daniel Raftery, Anup Madan, Xiulan Yang, Jesse Macadangdang, Alec S.T. Smith, Damien Detraux, Anu Suomalainen, Megan R. Showalter, Peter Hofsteen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
Nature Communications
Nature Communications, vol 10, iss 1
Nature communications, vol 10, iss 1
Nature Communications
Nature Communications, vol 10, iss 1
Nature communications, vol 10, iss 1
Mitochondrial trifunctional protein deficiency, due to mutations in hydratase subunit A (HADHA), results in sudden infant death syndrome with no cure. To reveal the disease etiology, we generated stem cell-derived cardiomyocytes from HADHA-deficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cdc63d7fbf74e7df48ed51331e7b932
https://doaj.org/article/eb9585b9475b4ec39e5021a1cc4c96fb
https://doaj.org/article/eb9585b9475b4ec39e5021a1cc4c96fb
Autor:
David L. Mack, Lisa Maves, Alec S.T. Smith, Jeanot Muster, Wendy W. Weston, Greg Potter, Alain Rostain, Nguyen T.K. Vo, Alessandro Bertero
The global demand for fish is rising and projected to increase for years to come. However, there is uncertainty whether this increased demand can be met by the conventional approaches of capture fisheries and fish farming because of wild stock deplet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1f382b8420214c712eddf0a859f9c9
http://hdl.handle.net/2318/1804552
http://hdl.handle.net/2318/1804552