Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alec R. Nickolls"'
Autor:
Luis O. Romero, Rebeca Caires, Alec R. Nickolls, Alexander T. Chesler, Julio F. Cordero-Morales, Valeria Vásquez
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
PIEZO2 is a critical component of the mechanism by which innocuous touch causes pain (tactile allodynia). Here, authors find that the dietary fatty acid margaric acid decreases PIEZO2 function in a dose-dependent manner and counteracts neuronal mecha
Externí odkaz:
https://doaj.org/article/e581e953bfe048c495f317467c7b666c
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 6 (2020)
The basal lamina is a specialized sheet of dense extracellular matrix (ECM) linked to the plasma membrane of specific cell types in their tissue context, which serves as a structural scaffold for organ genesis and maintenance. Disruption of the basal
Externí odkaz:
https://doaj.org/article/b61cdc6b70ea4e039f645b38fb98e9b7
Autor:
Alec R. Nickolls, Michelle M. Lee, David F. Espinoza, Marcin Szczot, Ruby M. Lam, Qi Wang, Jeanette Beers, Jizhong Zou, Minh Q. Nguyen, Hans J. Solinski, Aisha A. AlJanahi, Kory R. Johnson, Michael E. Ward, Alexander T. Chesler, Carsten G. Bönnemann
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 932-946.e7 (2020)
Summary: Efficient and homogeneous in vitro generation of peripheral sensory neurons may provide a framework for novel drug screening platforms and disease models of touch and pain. We discover that, by overexpressing NGN2 and BRN3A, human pluripoten
Externí odkaz:
https://doaj.org/article/4d1eff25ee1e41209004e08f2fde2c60
Autor:
Alec R. Nickolls, Carsten G. Bönnemann
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 12 (2018)
Dystroglycan is a cell membrane protein that binds to the extracellular matrix in a variety of mammalian tissues. The α-subunit of dystroglycan (αDG) is heavily glycosylated, including a special O-mannosyl glycoepitope, relying upon this unique gly
Externí odkaz:
https://doaj.org/article/bb70da7921764496847692f5ce32a0b4
Autor:
Luis O. Romero, Rebeca Caires, Alec R. Nickolls, Alexander T. Chesler, Julio F. Cordero-Morales, Valeria Vásquez
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/76a374d741b44616bc004b21d90cf49c
Autor:
Alec R Nickolls, Gabrielle S O'Brien, Sarah Shnayder, Yunxiao Zhang, Maximilian Nagel, Ardem Patapoutian, Alexander T Chesler
Publikováno v:
eLife, Vol 11 (2022)
Piezo1 is a stretch-gated ion channel required for mechanosensation in many organ systems. Recent findings point to a new role for Piezo1 in the gut, suggesting that it is a sensor of microbial single-stranded RNA (ssRNA) rather than mechanical force
Externí odkaz:
https://doaj.org/article/2b8870343a25483fb012904d1441ec39
Publikováno v:
Annu Rev Biochem
Mechanosensation is the ability to detect dynamic mechanical stimuli (e.g., pressure, stretch, and shear stress) and is essential for a wide variety of processes, including our sense of touch on the skin. How touch is detected and transduced at the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144bd49dab15f5f47b2b8a167da3d7ac
https://pubmed.ncbi.nlm.nih.gov/34153212
https://pubmed.ncbi.nlm.nih.gov/34153212
Autor:
Florian P. Thomas, Carsten G. Bönnemann, Zoe Piccus, Aliza Zidell, Ana Lucila Moreira, Matthew Nalls, S. Neuhaus, Mark A. Tarnopolsky, Helio Pedro, Fernando Kok, Eric Mittelmann, Kenneth Gable, Lauren Brady, Chamindra G. Konersman, Teresa M. Dunn, Anne M. Connolly, Alessandro Introna, Katherine R. Chao, Robert H. Brown, Tracy Brandt, Sabine Specht, Thorsten Hornemann, Museer A. Lone, Alec R. Nickolls, Volker Straub, Andreas Roos, Ahmet Hoke, Giancarlo Logroscino, Chiara Fiorillo, Claire E. Le Pichon, Chia-Hsueh Lee, Cindy V. Ly, A. Reghan Foley, Dimah Saade, Megan T. Cho, Sita D. Gupta, Ying Hu, Payam Mohassel, Andrea Gangfuß, Heike Kölbel, Christopher Grunseich, Jonas Alex Morales Saute, Sandra Donkervoort, Ana Töpf, Ulrike Schara, Naemeh Pourshafie
Publikováno v:
Nat Med
Nature Medicine
Web of Science
Nature Medicine
Web of Science
Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative disease of the lower and upper motor neurons with sporadic or hereditary occurrence. Age of onset, pattern of motor neuron degeneration and disease progression vary widely among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3193b2001356b95896ddd8445463da1b
https://pubmed.ncbi.nlm.nih.gov/34059824
https://pubmed.ncbi.nlm.nih.gov/34059824
Publikováno v:
Biophysical Journal. 121:494a-495a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69504c7e19fc5cd175f316c14d1b346a
https://doi.org/10.1016/j.bpj.2021.11.329
https://doi.org/10.1016/j.bpj.2021.11.329