Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alec Okun"'
Autor:
Alec Okun, Bethany Remeniuk, Frank Porreca, Jennifer Y. Xie, Edita Navratilova, Devki Sukhtankar, Tamara King
Publikováno v:
Pain
Behavioral and neurochemical analysis of ongoing bone cancer pain demonstrating that the intrinsic reward of morphine can be dissociated from the reward of pain relief.
Cancer-induced bone pain is described as dull, aching ongoing pain. Ongoing
Cancer-induced bone pain is described as dull, aching ongoing pain. Ongoing
Autor:
David L. McKinzie, Omar Husain, Frank Porreca, Stephen L. Cowen, Alec Okun, Jeffrey M. Witkin, Caroline E. Phelps, Edita Navratilova, Scott D. Gleason
Publikováno v:
Pain. 159(7)
Cognitive flexibility, the ability to adapt behavior to changing outcomes, is critical to survival. The prefrontal cortex is a key site of cognitive control, and chronic pain is known to lead to significant morphological changes to this brain region.
Autor:
Timothy Tiutan, Bethany Remeniuk, Frank Porreca, Jonathan Gentry, Alec Okun, J. Havelin, Ian Imbert, Tamara King, Devki Sukhtankar, Ian Pelletier
Cancer-induced bone pain is characterized by moderate to severe ongoing pain that commonly requires the use of opiates. Even when ongoing pain is well controlled, patients can suffer breakthrough pain (BTP), episodic severe pain that “breaks throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9fb13872e0197b2c7a074401deb872
https://europepmc.org/articles/PMC5444195/
https://europepmc.org/articles/PMC5444195/
Autor:
Frank Porreca, Alec Okun, Ohannes K. Melemedjian, Theodore J. Price, Irina Y. Maskaykina, Gregory Dussor, Edward K. Mandell, Chaoling Qu, Tamara King, Edita Navratilova, Sourav Ghosh
Publikováno v:
Pain. 153:1263-1273
Injuries can induce adaptations in pain processing that result in amplification of signaling. One mechanism may be analogous to long-term potentiation and involve the atypical protein kinase C, PKMζ. The possible contribution of PKMζ-dependent and
Autor:
Jennifer Y. Xie, Peg Davis, Ping Liu, Alec Okun, Michael H. Ossipov, Frank Porreca, Triza Brion, Bethany Remeniuk, Jiyang Ren, Tamara King, Gregory Dussor
Publikováno v:
Pain. 153:924-933
Osteoarthritis (OA) is a chronic condition characterized by pain during joint movement. Additionally, patients with advanced disease experience pain at rest (ie, ongoing pain) that is generally resistant to nonsteroidal antiinflammatory drugs. Inject
Autor:
Frank Porreca, Jiyang Ren, Josephine Lai, Triza Brion, Tamara King, Chaoling Qu, Alec Okun, Ramon Mercado
Publikováno v:
Pain. 152:1997-2005
A predominant complaint in patients with neuropathic pain is spontaneous pain, often described as burning. Recent studies have demonstrated that negative reinforcement can be used to unmask spontaneous neuropathic pain, allowing for mechanistic inves
Autor:
Frank Porreca, Alec Okun, Ping Liu, Jiyang Ren, Tamara King, Rui Chen Guo, Michael H. Ossipov, Jennifer Y. Xie
Publikováno v:
Neuroscience Letters. 493:72-75
Osteoarthritis (OA) is a chronic pain condition characterized by pain during joint use as well as pain at rest (i.e., ongoing pain). Although injection of monosodium iodoacetate (MIA) into the intra-articular space of the rodent knee is a well establ
Autor:
Howard L. Fields, Frank Porreca, Diana S Meske, Naohisa Arakawa, Edita Navratilova, Jennifer Y. Xie, Kozo Morimura, Michael H. Ossipov, Alec Okun, Chaoling Qu
Publikováno v:
Navratilova, E; Xie, JY; Meske, D; Qu, C; Morimura, K; Okun, A; et al.(2015). Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain. Journal of Neuroscience, 35(18), 7264-7271. doi: 10.1523/JNEUROSCI.3862-14.2015. UCSF: Retrieved from: http://www.escholarship.org/uc/item/4cn5j6kq
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 35, iss 18
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 35, iss 18
Pain is aversive, and its relief elicits reward mediated by dopaminergic signaling in the nucleus accumbens (NAc), a part of the mesolimbic reward motivation pathway. How the reward pathway is engaged by pain-relieving treatments is not known. Endoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3170891dfdb1dd3974c0f892334f1c
http://www.escholarship.org/uc/item/4cn5j6kq
http://www.escholarship.org/uc/item/4cn5j6kq
Autor:
Shuang Ci, Alec Okun, Nathan Eyde, Michael H. Ossipov, Jennifer Y. Xie, Frank Porreca, Howard L. Fields, Tamara King, Edita Navratilova, Chaoling Qu
Relief of pain is rewarding. Using a model of experimental postsurgical pain we show that blockade of afferent input from the injury with local anesthetic elicits conditioned place preference, activates ventral tegmental dopaminergic cells, and incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652519c12d9cb5995efc9e11e863afa7
https://europepmc.org/articles/PMC3528534/
https://europepmc.org/articles/PMC3528534/
Autor:
Shuang Ci, Edita Navratilova, Frank Porreca, Nathan Eyde, Michael H. Ossipov, Tamara King Deeny, Alec Okun, Jennifer Y. Xie
Publikováno v:
The FASEB Journal. 26