Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Alec Kittredge"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Bestrophin-1 (Best1) is an anion channel genetically linked to vision-threatening retinal degenerative channelopathies. Here, we identify interactions between Best1 and both isoforms of glutamic acid decarboxylases (GAD65 and GAD67), elucida
Externí odkaz:
https://doaj.org/article/4ac797b8450a49db9b39a38561ffa21c
Autor:
Aaron P. Owji, Jiali Wang, Alec Kittredge, Zada Clark, Yu Zhang, Wayne A. Hendrickson, Tingting Yang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Bestrophin channels are critical for physiology of the eye. Here, authors report cryo-EM structures of human bestrophins in various states at up to 1.8 Å resolution, revealing paralog-specific features that underlie molecular mechanisms of permeatio
Externí odkaz:
https://doaj.org/article/f20545733ff64a9199865a3c3234ef9b
Autor:
Qingqing Zhao, Yang Kong, Alec Kittredge, Yao Li, Yin Shen, Yu Zhang, Stephen H Tsang, Tingting Yang
Publikováno v:
eLife, Vol 10 (2021)
Genetic mutation of the human BEST1 gene, which encodes a Ca2+-activated Cl- channel (BEST1) predominantly expressed in retinal pigment epithelium (RPE), causes a spectrum of retinal degenerative disorders commonly known as bestrophinopathies. Previo
Externí odkaz:
https://doaj.org/article/c7a01771d5c74570aa5269d460e9616d
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Human Bestrophin1 (hBest1), a calcium-activated chloride channel in retinal pigment epithelium (RPE), is essential for retina physiology. Using electrophysiological and structural approaches, the authors uncover an ATP-dependent activation mechanism
Externí odkaz:
https://doaj.org/article/d2fbb4e9fd0d4e02a648786cc5e5354a
Autor:
Yao Li, Yu Zhang, Yu Xu, Alec Kittredge, Nancy Ward, Shoudeng Chen, Stephen H Tsang, Tingting Yang
Publikováno v:
eLife, Vol 6 (2017)
Mutations in the human BEST1 gene lead to retinal degenerative diseases displaying progressive vision loss and even blindness. BESTROPHIN1, encoded by BEST1, is predominantly expressed in retinal pigment epithelium (RPE), but its physiological role h
Externí odkaz:
https://doaj.org/article/067652ba43394dba9d4ea9a3d1534c2e
Publikováno v:
Channels
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Bestrophins are a family of calcium-activated chloride channels (CaCCs) with relevance to human physiology and a myriad of eye diseases termed “bestrophinopathies”. Since the identification of bestrophins as CaCCs nearly two decades ago, extensiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a74b6b2127b7032b462c30e272b245
https://doi.org/10.1080/19336950.2021.1981625
https://doi.org/10.1080/19336950.2021.1981625
Publikováno v:
Nature
Bestrophin-2 (Best2) is a member of the bestrophin family of calcium-activated anion channels with critical involvement in ocular physiology(1–4). Here, we uncover a directional permeability of Best2 to glutamate heavily favoring glutamate exit, id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957df93ed8d0326cc12496be8b1b4738
https://pubmed.ncbi.nlm.nih.gov/36289327
https://pubmed.ncbi.nlm.nih.gov/36289327
Autor:
Tingting Yang, Nancy Ward, Alec Kittredge, Shoudeng Chen, Yu Zhang, Changyi Ji, Yohta Fukuda, Austin Hopiavuori
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
Communications Biology
Communications Biology
Mutations of human BEST1, encoding a Ca2+-activated Cl− channel (hBest1), cause macular degenerative disorders. Best1 homolog structures reveal an evolutionarily conserved channel architecture highlighted by two landmark restrictions (named the “
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585170a3e4895274a5806eebd6b3dd01
http://link.springer.com/article/10.1038/s42003-019-0433-3
http://link.springer.com/article/10.1038/s42003-019-0433-3
Autor:
Ting-Ting Yang, Aaron Owji, Jiali Wang, Alec Kittredge, Zada Clark, Yu Zhang, Wayne A. Hendrickson
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 78:a252-a252
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58e442dcb34eac68a67f7057fdc15854
https://doi.org/10.1107/s2053273322097479
https://doi.org/10.1107/s2053273322097479
Autor:
Tingting Yang, Qingqing Zhao, Alec Kittredge, Yin Shen, Stephen H. Tsang, Yu Zhang, Yang Kong, Yao Li
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Genetic mutation of the human BEST1 gene, which encodes a Ca2+-activated Cl- channel (BEST1) predominantly expressed in retinal pigment epithelium (RPE), causes a spectrum of retinal degenerative disorders commonly known as bestrophinopathies. Previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3377e6926f2c70f8a016874450b2c931
http://europepmc.org/articles/PMC8169119
http://europepmc.org/articles/PMC8169119