Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Alec J. Vincent"'
Autor:
Georgios Marinos, Joao B. Mokochinski, Matthias Laudes, Claudia Lennicke, Alec J. Vincent, Christoph Kaleta, Lucie A.G. van Leeuwen, Eliano dos Santos, Esther van Dam, Joel James, Marcela Buricova, Holger Kramer, Andrea Foley, Andre Franke, Lena Best, Helena M. Cochemé, Wolfgang Lieb
Publikováno v:
Aging (Albany NY)
Cell Metabolism
Cell Metabolism
Summary High-sugar diets cause thirst, obesity, and metabolic dysregulation, leading to diseases including type 2 diabetes and shortened lifespan. However, the impact of obesity and water imbalance on health and survival is complex and difficult to d
Autor:
James H, Catterson, Mobina, Khericha, Miranda C, Dyson, Alec J, Vincent, Rebecca, Callard, Steven M, Haveron, Arjunan, Rajasingam, Mumtaz, Ahmad, Linda, Partridge
Publikováno v:
Current Biology
Summary Intermittent fasting (IF) can improve function and health during aging in laboratory model organisms, but the mechanisms at work await elucidation. We subjected fruit flies (Drosophila melanogaster) to varying degrees of IF and found that jus
Autor:
Chi Tung Wong, Alec J. Vincent, Linda Partridge, Jennifer Adcott, Marcus J. Allen, Emmanuel Boucrot, Hrvoje Augustin, Fiona Kerr, Sirisha Kudumala Madem, Kieran McGourty, Tanja A. Godenschwege
Publikováno v:
PLoS Biol
PLoS Biology
PLoS Biology, Vol 15, Iss 9, p e2001655 (2017)
PLoS Biology
PLoS Biology, Vol 15, Iss 9, p e2001655 (2017)
Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the “insulin paradox”). Chronic, moderately lowered IIS rescues age-related decline in n
Autor:
Teresa Niccoli, Melissa Cabecinha, Anna Tillmann, Fiona Kerr, Chi T. Wong, Dalia Cardenes, Alec J. Vincent, Lucia Bettedi, Li Li, Sebastian Grönke, Jacqueline Dols, Linda Partridge
Publikováno v:
Current Biology
Summary Glucose hypometabolism is a prominent feature of the brains of patients with Alzheimer’s disease (AD). Disease progression is associated with a reduction in glucose transporters in both neurons and endothelial cells of the blood-brain barri