Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Alec Guiblin"'
Autor:
Leslie J. Street, George R. Marshall, Bindi Sohal, Ruth M. McKernan, Andrew Mitchinson, Susan M. Cook, Andrew Pike, José L. Castro, Robert W. Carling, Timothy Harrison, Ian C. Ragan, Sally Ann Thompson, John R. Atack, K Quirk, Andrew Madin, Kevin W. Moore, Michael G. N. Russell, Alec Guiblin, Keith A. Wafford, Gerard R. Dawson, Pushpinder Ferris
Publikováno v:
Journal of Medicinal Chemistry. 48:7089-7092
There is increasing evidence that compounds with selectivity for gamma-aminobutyric acid(A) (GABA(A)) alpha2- and/or alpha3-subtypes may retain the desirable anxiolytic activity of nonselective benzodiazepines but possess an improved side effect prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5669d56878a0d056aa7267380a12e4df
https://doi.org/10.1021/jm058034a
https://doi.org/10.1021/jm058034a
Autor:
Alan P. Watt, Susan M. Cook, Alec Guiblin, Christopher Moyes, Ruth M. McKernan, Bindi Sohal, John R. Atack, Luanda J. Pym, Thomas W. Rosahl, Andrew Pike, Paul Scott-Stevens
Publikováno v:
Biopharmaceuticsdrug disposition. 28(6)
The in vivo occupancy of brain benzodiazepine binding sites by compounds A and B was measured using a [3H]Ro 15-1788 binding assay and related to plasma and brain drug concentrations. The plasma concentration associated with 50% occupancy was higher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9821a97492e2052166a18be4e82a001f
https://pubmed.ncbi.nlm.nih.gov/17570124
https://pubmed.ncbi.nlm.nih.gov/17570124
Autor:
Robert W, Carling, Andrew, Madin, Alec, Guiblin, Michael G N, Russell, Kevin W, Moore, Andrew, Mitchinson, Bindi, Sohal, Andrew, Pike, Susan M, Cook, Ian C, Ragan, Ruth M, McKernan, Kathleen, Quirk, Pushpinder, Ferris, George, Marshall, Sally Ann, Thompson, Keith A, Wafford, Gerard R, Dawson, John R, Atack, Timothy, Harrison, José L, Castro, Leslie J, Street
Publikováno v:
Journal of medicinal chemistry. 48(23)
There is increasing evidence that compounds with selectivity for gamma-aminobutyric acid(A) (GABA(A)) alpha2- and/or alpha3-subtypes may retain the desirable anxiolytic activity of nonselective benzodiazepines but possess an improved side effect prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a11d1ee79c8642933071ece34a27f2e3
https://pubmed.ncbi.nlm.nih.gov/16279764
https://pubmed.ncbi.nlm.nih.gov/16279764
Autor:
Leslie J. Street, Francine Sternfeld, Margaret S. Beer, H Routledge, R. Baker, A. P. Watt, Richard Alexander Jelley, Alec Guiblin, W B Davey, Austin John Reeve
Publikováno v:
Journal of medicinal chemistry. 38(10)
The synthesis and the 5-HT receptor activity of a novel series of N,N-dimethyltryptamines substituted in the 5-position with an imidazole, triazole, or tetrazole ring are described. The objective of this work was to identify potent and selective 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f391fb604112a873db3a071080254f
https://pubmed.ncbi.nlm.nih.gov/7752204
https://pubmed.ncbi.nlm.nih.gov/7752204