‘It depends’: what 86 systematic reviews tell us about what strategies to use to support the use of research in clinical practice

Autor: Annette Boaz, Juan Baeza, Alec Fraser, Erik Persson

Publikováno v: Implementation Science, Vol 19, Iss 1, Pp 1-30 (2024)

Abstract Background The gap between research findings and clinical practice is well documented and a range of strategies have been developed to support the implementation of research into clinical practice. The objective of this study was to update a

Externí odkaz: https://doaj.org/article/dda6caf9450549bab9afcdc4481b0ff2

Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase

Autor: Alec Fraser, Maria L. Sokolova, Arina V. Drobysheva, Julia V. Gordeeva, Sergei Borukhov, John Jumper, Konstantin V. Severinov, Petr G. Leiman

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Promoter recognition is a critical step in the initiation of transcription of DNA to RNA. Here, the authors describe a novel mechanism by which a phage-encoded RNA polymerase recognizes viral promoters containing deoxyuridines instead of thymidines.

Externí odkaz: https://doaj.org/article/721111b55e21403f9a09179504ea30f4

‘Holding the line’: a qualitative study of the role of evidence in early phase decision-making in the reconfiguration of stroke services in London

Autor: Alec Fraser, Juan I. Baeza, Annette Boaz

Publikováno v: Health Research Policy and Systems, Vol 15, Iss 1, Pp 1-9 (2017)

Abstract Background Health service reconfigurations are of international interest but remain poorly understood. This article focuses on the use of evidence by senior managerial decision-makers involved in the reconfiguration of stroke services in Lon

Externí odkaz: https://doaj.org/article/d312a287d0ea4e2b95d40137320aa49b

The Impact of Social Impact Bond Financing

Autor: Debra Hevenstone, Alec Fraser, Lukas Hobi, Wojtek Przepiorka, Gemma G. M. Geuke

Publikováno v: Hevenstone, D, Fraser, A, Hobi, L, Przepiorka, W & Geuke, G 2023, ' The Impact of Social Impact Bond Financing ', PUBLIC ADMINISTRATION REVIEW, vol. 83, no. 4, pp. 930-946 . https://doi.org/10.1111/puar.13631

Social Impact Bonds (SIBs), also known as Pay-for-Success, are an innovation in Payment by Results contracting. Investors finance programs and are repaid based on the “SIB effect,” which includes changes in outcomes attributable to financing. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3059bff4e183684d5f154950a48b3100
https://kclpure.kcl.ac.uk/en/publications/9b8be82f-73f2-4a5f-b0fe-e8cee91a36a2

Computational models in the service of X‐ray and cryo‐ electron microscopy structure determination

Autor: Reinhard Albrecht, Inokentijs Josts, Daniel C. Nelson, Petr G. Leiman, Sara B. Linden, Steven D. Rees, Andriy Kryshtafovych, Kinlin L. Chao, Osnat Herzberg, Geoffrey Chang, John Moult, Andrei N. Lupas, Alec Fraser, Marcus D. Hartmann, Alpha Fold team, Julia Greenfield, Henning Tidow, Maria L. Sokolova, Xiaoran Shang

Publikováno v: Proteins

Critical assessment of structure prediction (CASP) conducts community experiments to determine the state of the art in computing protein structure from amino acid sequence. The process relies on the experimental community providing information about

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697f2aff4856d823bda631bd34762686
https://doi.org/10.1002/prot.26223