Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alec D. Witty"'
Autor:
Jennifer Veevers, Elie N. Farah, Mirko Corselli, Alec D. Witty, Karina Palomares, Jason G. Vidal, Nil Emre, Christian T. Carson, Kunfu Ouyang, Canzhao Liu, Patrick van Vliet, Maggie Zhu, Jeffrey M. Hegarty, Dekker C. Deacon, Jonathan D. Grinstein, Ralf J. Dirschinger, Kelly A. Frazer, Eric D. Adler, Kirk U. Knowlton, Neil C. Chi, Jody C. Martin, Ju Chen, Sylvia M. Evans
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 828-841 (2018)
Summary: To facilitate understanding of human cardiomyocyte (CM) subtype specification, and the study of ventricular CM biology in particular, we developed a broadly applicable strategy for enrichment of ventricular cardiomyocytes (VCMs) derived from
Externí odkaz:
https://doaj.org/article/130cb26d040c415ba92bc654a197ec5a
Autor:
Charles Yoon, Hannah Song, Ting Yin, Damaris Bausch-Fluck, Andreas P. Frei, Steven Kattman, Nicole Dubois, Alec D. Witty, Johannes A. Hewel, Hongbo Guo, Andrew Emili, Bernd Wollscheid, Gordon Keller, Peter W. Zandstra
Publikováno v:
Stem Cell Reports, Vol 10, Iss 1, Pp 87-100 (2018)
Summary: The identification of cell surface proteins on stem cells or stem cell derivatives is a key strategy for the functional characterization, isolation, and understanding of stem cell population dynamics. Here, using an integrated mass spectrome
Externí odkaz:
https://doaj.org/article/e9e801d67a074496afbb27fe853f32ac
Autor:
Han Xu, Mark L. Sandberg, Nimalan Thavandiran, Mohsen Afshar Bakooshli, George Graham, Philip Tagari, Milica Radisic, Andrew B.J. Prowse, Samuel McEwen, Michele McElvain, Hon Le, Andreea Norman, Erik Chau, Christopher M. Hale, Alec D. Witty, Van T. H. Do, Mark Gagliardi, Penney M. Gilbert, Patrick H. Blit, Bo Sun, Peter W. Zandstra, Joel Ostblom, Ian Fernandes, Gordon Keller
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
To accelerate the cardiac drug discovery pipeline, we set out to develop a platform that would be capable of quantifying tissue-level functions such as contractile force and be amenable to standard multiwell-plate manipulations. We report a 96-well-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27a84b32deccbdf437c193f233a617f
https://doi.org/10.1038/s41598-020-62955-3
https://doi.org/10.1038/s41598-020-62955-3
Autor:
Nil Emre, Jeffrey M. Hegarty, Kirk U. Knowlton, Alec D. Witty, Canzhao Liu, Dekker C. Deacon, Kelly A. Frazer, Jason G. Vidal, Elie Farah, Karina Palomares, Sylvia M. Evans, Mirko Corselli, Christian T. Carson, Patrick van Vliet, Maggie Zhu, Ralf J. Dirschinger, Eric Adler, Jennifer Veevers, Kunfu Ouyang, Jonathan D. Grinstein, Neil C. Chi, Ju Chen, Jody Martin
Publikováno v:
Stem cell reports, vol 11, iss 3
Stem Cell Reports, Vol 11, Iss 3, Pp 828-841 (2018)
Stem Cell Reports, Vol 11, Iss 3, Pp 828-841 (2018)
Summary: To facilitate understanding of human cardiomyocyte (CM) subtype specification, and the study of ventricular CM biology in particular, we developed a broadly applicable strategy for enrichment of ventricular cardiomyocytes (VCMs) derived from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f29c4e6d6759c66d97ccf51ddd6fffd
https://doi.org/10.1016/j.stemcr.2018.07.007
https://doi.org/10.1016/j.stemcr.2018.07.007
Autor:
Johannes A. Hewel, Hongbo Guo, Peter W. Zandstra, Steven Kattman, Gordon Keller, Andrew Emili, Ting Yin, Alec D. Witty, Charles Yoon, Hannah Song, Nicole Dubois, Damaris Bausch-Fluck, Andreas P. Frei, Bernd Wollscheid
Publikováno v:
Stem Cell Reports, 10 (1)
Stem Cell Reports
Stem Cell Reports, Vol 10, Iss 1, Pp 87-100 (2018)
Stem Cell Reports
Stem Cell Reports, Vol 10, Iss 1, Pp 87-100 (2018)
Summary The identification of cell surface proteins on stem cells or stem cell derivatives is a key strategy for the functional characterization, isolation, and understanding of stem cell population dynamics. Here, using an integrated mass spectromet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fd0624a953e6080d43d103fa16f237
https://doi.org/10.1016/j.stemcr.2017.11.008
https://doi.org/10.1016/j.stemcr.2017.11.008
Autor:
Michele McElvain, Mark Gagliardi, Alykhan Motani, Hugo M. Vargas, Bo Sun, Samuel McEwen, Penney M. Gilbert, Jeff D. Reagan, Mark L. Sandberg, Milica Radisic, Han Xu, Peter W. Zandstra, May Mcintosh, Dana Nojima, Mohsen Afshar Bakooshli, Patrick H. Blit, Philip Tagari, Alec D. Witty, Joel Ostblom, Gordon Keller, Nimalan Thavandiran, Andrew B.J. Prowse, Ian Fernandes, George Graham, Erik Chau, Yusheng Qu, Christopher M. Hale, Hon Le
To accelerate the cardiac drug discovery pipeline, we set out to develop a platform that would be amenable to standard multiwell-plate manipulations and be capable of quantifying tissue-level functions such as contractile force. We report a 96-well-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb2650757d9b872a3374f0e5adf5732
Autor:
Xuanyi Ma, Shaochen Chen, Elie Farah, Weizhe Xu, Hannah G. Knight, Rima Deshpande, Joshua Bloomekatz, Ruilin Zhang, Neil C. Chi, Deborah Yelon, Peidong Han, Alec D. Witty, Xin-Xin I. Zeng, Jie Ren, Megan M. Swim
Publikováno v:
Developmental cell. 50(6)
Pacemaker cardiomyocytes that create the sinoatrial node are essential for the initiation and maintenance of proper heart rhythm. However, illuminating developmental cues that direct their differentiation has remained particularly challenging due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51de43a41bfb3899afc56d1021a77dbd
https://pubmed.ncbi.nlm.nih.gov/31550460
https://pubmed.ncbi.nlm.nih.gov/31550460
Autor:
Robert Lerrigo, Taiyi Kuo, Won-Suk Chung, Sruthy Maria Augustine, Dominika Tworus, Shujun Luo, Neil C. Chi, Suk-Won Jin, Miler T. Lee, Björn Nystedt, Ian T. Fiddes, Michele Marass, Didier Y.R. Stainier, Oliver A. Stone, Jessica Alsiö, Antonio J. Giraldez, Alec D. Witty, Nana Fukuda, Olov Andersson, Sophie Mucenieks, Gary P. Schroth, Sherveen Salek, Marcel Martin, Alethia Villasenor, Sven Reischauer
Publikováno v:
Nature. 535:294-298
Vascular and haematopoietic cells organize into specialized tissues during early embryogenesis to supply essential nutrients to all organs and thus play critical roles in development and disease. At the top of the haemato-vascular specification casca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acff299393a18bac1e2c8170c7a711a6
https://doi.org/10.1038/nature18614
https://doi.org/10.1038/nature18614
Autor:
Hans R. Schöler, Sigrid Fuchs, Ali El-Armouche, Alexander Becker, Thomas Rau, Thomas Eschenhagen, Michael Rubart, Dong Wook Han, Martin Zenke, Bernhard Unsöld, Claudia Lange, Udo Schumacher, Peter Christalla, Alec D. Witty, Steven J. Kattman, Michael Didié, Stephan Döker, Heimo Ehmke, Gordon Keller, Vijayakumar Muppala, Mark H. Soonpaa, Loren J. Field, Tao Yang, Cornelia Rudolph, Wolfram-Hubertus Zimmermann, Brigitte Schlegelberger, Wen Tao, Doris Steinemann, Qiong Lin, John A. Scherschel, Alexander P. Schwoerer
Publikováno v:
The Journal of Clinical Investigation, 123(3), 1285-1298. AMER SOC CLINICAL INVESTIGATION INC
Uniparental parthenotes are considered an unwanted byproduct of in vitro fertilization. In utero parthenote development is severely compromised by defective organogenesis and in particular by defective cardiogenesis. Although developmentally compromi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e1529069743af12746369a2f34caad
https://hdl.handle.net/11370/782743a5-91c1-4863-abc3-7fcade88a605
https://hdl.handle.net/11370/782743a5-91c1-4863-abc3-7fcade88a605
Autor:
James Ellis, Alec D. Witty, Maryam Niapour, Gordon Keller, Steven J. Kattman, Mark Gagliardi, Akitsu Hotta, Nicole Dubois
Publikováno v:
Cell stem cell
Efficient differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) to a variety of lineages requires step-wise approaches replicating the key commitment stages found during embryonic development. Here we show that exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d3f33a1d90b3a5ade1c5934bb28918
https://doi.org/10.1016/j.stem.2010.12.008
https://doi.org/10.1016/j.stem.2010.12.008