Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Alec C Kimmelman"'
Autor:
Joseph D Mancias, Laura Pontano Vaites, Sahar Nissim, Douglas E Biancur, Andrew J Kim, Xiaoxu Wang, Yu Liu, Wolfram Goessling, Alec C Kimmelman, J Wade Harper
Publikováno v:
eLife, Vol 4 (2015)
NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is controlled and the roles of NCOA4 in iron-dependent processes ar
Externí odkaz:
https://doaj.org/article/5af6e8d673d04762ad593f5eaec09092
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39588 (2012)
Pancreatic ductal adenocarcinoma (PDAC) is amongst the deadliest of human cancers, due to its late diagnosis as well as its intense resistance to currently available therapeutics. To identify mechanisms as to why PDAC are refractory to DNA damaging c
Externí odkaz:
https://doaj.org/article/d6d25fe241c34873a154190065e0de4c
Autor:
Seth J. Parker, Joel Encarnación-Rosado, Kate E. R. Hollinshead, David M. Hollinshead, Leonard J. Ash, Juan A. K. Rossi, Elaine Y. Lin, Albert S. W. Sohn, Mark R. Philips, Drew R. Jones, Alec C. Kimmelman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Analogues of α-ketoglutarate are used in many cellular studies but assumptions are made about cellular uptake. Here, the authors show that esterified analogues rapidly hydrolyse in aqueous medium resulting in an analogue which can be quickly taken u
Externí odkaz:
https://doaj.org/article/a430c84ac3014555b5b20af966982f02
Autor:
Barbara S. Nelson, Lin Lin, Daniel M. Kremer, Cristovão M. Sousa, Cecilia Cotta-Ramusino, Amy Myers, Johanna Ramos, Tina Gao, Ilya Kovalenko, Kari Wilder-Romans, Joseph Dresser, Mary Davis, Ho-Joon Lee, Zeribe C. Nwosu, Scott Campit, Oksana Mashadova, Brandon N. Nicolay, Zachary P. Tolstyka, Christopher J. Halbrook, Sriram Chandrasekaran, John M. Asara, Howard C. Crawford, Lewis C. Cantley, Alec C. Kimmelman, Daniel R. Wahl, Costas A. Lyssiotis
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract Background Metabolic programs in cancer cells are influenced by genotype and the tissue of origin. We have previously shown that central carbon metabolism is rewired in pancreatic ductal adenocarcinoma (PDA) to support proliferation through
Externí odkaz:
https://doaj.org/article/e08285467c004f0193e607f0286f4ab7
Autor:
Koelina Ganguly, Alec C. Kimmelman
Publikováno v:
Trends in Cancer. 9:461-471
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::822867b29b52ee89575673b5a698dc20
https://doi.org/10.1016/j.trecan.2023.02.005
https://doi.org/10.1016/j.trecan.2023.02.005
Autor:
Mohamad Assi, Alec C. Kimmelman
Publikováno v:
Nature Cancer. 4:596-607
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e8345c782d4d8380218ee465b9fbdf5
https://doi.org/10.1038/s43018-023-00546-7
https://doi.org/10.1038/s43018-023-00546-7
Autor:
Joseph Tintelnot, Yang Xu, Till R. Lesker, Martin Schönlein, Leonie Konczalla, Anastasios D. Giannou, Penelope Pelczar, Dominik Kylies, Victor G. Puelles, Agata A. Bielecka, Manuela Peschka, Filippo Cortesi, Kristoffer Riecken, Maximilian Jung, Lena Amend, Tobias S. Bröring, Marija Trajkovic-Arsic, Jens T. Siveke, Thomas Renné, Danmei Zhang, Stefan Boeck, Till Strowig, Faik G. Uzunoglu, Cenap Güngör, Alexander Stein, Jakob R. Izbicki, Carsten Bokemeyer, Marianne Sinn, Alec C. Kimmelman, Samuel Huber, Nicola Gagliani
Publikováno v:
Tintelnot, J, Xu, Y, Lesker, T R, Schönlein, M, Konczalla, L, Giannou, A D, Pelczar, P, Kylies, D, Puelles, V G, Bielecka, A A, Peschka, M, Cortesi, F, Riecken, K, Jung, M, Amend, L, Bröring, T S, Trajkovic-Arsic, M, Siveke, J T, Renné, T, Zhang, D, Boeck, S, Strowig, T, Uzunoglu, F G, Güngör, C, Stein, A, Izbicki, J R, Bokemeyer, C, Sinn, M, Kimmelman, A C, Huber, S & Gagliani, N 2023, ' Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer ', Nature, vol. 615, no. 7950, pp. 168-174 . https://doi.org/10.1038/s41586-023-05728-y
Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly cancer by 2040, owing to the high incidence of metastatic disease and limited responses to treatment1,2. Less than half of all patients respond to the primary treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6958462eedf5593c667bb2b17214d3f0
https://doi.org/10.1038/s41586-023-05728-y
https://doi.org/10.1038/s41586-023-05728-y
Autor:
Naiara Santana-Codina, Anjali A. Roeth, Yi Zhang, Annan Yang, Oksana Mashadova, John M. Asara, Xiaoxu Wang, Roderick T. Bronson, Costas A. Lyssiotis, Haoqiang Ying, Alec C. Kimmelman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Pancreatic ductal adenocarcinoma (PDAC) cells display varying degrees of reliance on oncogenic KRAS. Here the authors show that KRAS-resistant PDAC cells maintain nucleotides synthesis through a KRAS-independent upregulation of the non-oxidative pent
Externí odkaz:
https://doaj.org/article/54e4abc4188c4609baed834f3f363f66
Autor:
Naiara Santana-Codina, Sebastian Gableske, Mark D. Fleming, J. Wade Harper, Alec C. Kimmelman, Joseph D. Mancias
Publikováno v:
Haematologica, Vol 104, Iss 12 (2019)
Externí odkaz:
https://doaj.org/article/226cce7966d141c48775aeb53d1034b4
Autor:
Douglas E. Biancur, Joao A. Paulo, Beata Małachowska, Maria Quiles Del Rey, Cristovão M. Sousa, Xiaoxu Wang, Albert S. W. Sohn, Gerald C. Chu, Steven P. Gygi, J. Wade Harper, Wojciech Fendler, Joseph D. Mancias, Alec C. Kimmelman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Glutaminase inhibition (GLSi) has promising activity against certain cancers. Here, the authors show that GLSi has no effect on multiple mouse models of pancreatic cancer and characterize the metabolic pathways activated in response to GLSi whose con
Externí odkaz:
https://doaj.org/article/3c1c97f9f96f44b8b385caffd639b374