Spontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters

Autor: Seth J. Parker, Joel Encarnación-Rosado, Kate E. R. Hollinshead, David M. Hollinshead, Leonard J. Ash, Juan A. K. Rossi, Elaine Y. Lin, Albert S. W. Sohn, Mark R. Philips, Drew R. Jones, Alec C. Kimmelman

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Analogues of α-ketoglutarate are used in many cellular studies but assumptions are made about cellular uptake. Here, the authors show that esterified analogues rapidly hydrolyse in aqueous medium resulting in an analogue which can be quickly taken u

Externí odkaz: https://doaj.org/article/a430c84ac3014555b5b20af966982f02

Reprogramming of tissue metabolism during cancer metastasis

Autor: Koelina Ganguly, Alec C. Kimmelman

Publikováno v: Trends in Cancer. 9:461-471

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::822867b29b52ee89575673b5a698dc20
https://doi.org/10.1016/j.trecan.2023.02.005

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Autor: Joseph Tintelnot, Yang Xu, Till R. Lesker, Martin Schönlein, Leonie Konczalla, Anastasios D. Giannou, Penelope Pelczar, Dominik Kylies, Victor G. Puelles, Agata A. Bielecka, Manuela Peschka, Filippo Cortesi, Kristoffer Riecken, Maximilian Jung, Lena Amend, Tobias S. Bröring, Marija Trajkovic-Arsic, Jens T. Siveke, Thomas Renné, Danmei Zhang, Stefan Boeck, Till Strowig, Faik G. Uzunoglu, Cenap Güngör, Alexander Stein, Jakob R. Izbicki, Carsten Bokemeyer, Marianne Sinn, Alec C. Kimmelman, Samuel Huber, Nicola Gagliani

Publikováno v: Tintelnot, J, Xu, Y, Lesker, T R, Schönlein, M, Konczalla, L, Giannou, A D, Pelczar, P, Kylies, D, Puelles, V G, Bielecka, A A, Peschka, M, Cortesi, F, Riecken, K, Jung, M, Amend, L, Bröring, T S, Trajkovic-Arsic, M, Siveke, J T, Renné, T, Zhang, D, Boeck, S, Strowig, T, Uzunoglu, F G, Güngör, C, Stein, A, Izbicki, J R, Bokemeyer, C, Sinn, M, Kimmelman, A C, Huber, S & Gagliani, N 2023, ' Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer ', Nature, vol. 615, no. 7950, pp. 168-174 . https://doi.org/10.1038/s41586-023-05728-y

Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly cancer by 2040, owing to the high incidence of metastatic disease and limited responses to treatment1,2. Less than half of all patients respond to the primary treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6958462eedf5593c667bb2b17214d3f0
https://doi.org/10.1038/s41586-023-05728-y

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis

Autor: Naiara Santana-Codina, Anjali A. Roeth, Yi Zhang, Annan Yang, Oksana Mashadova, John M. Asara, Xiaoxu Wang, Roderick T. Bronson, Costas A. Lyssiotis, Haoqiang Ying, Alec C. Kimmelman

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Pancreatic ductal adenocarcinoma (PDAC) cells display varying degrees of reliance on oncogenic KRAS. Here the authors show that KRAS-resistant PDAC cells maintain nucleotides synthesis through a KRAS-independent upregulation of the non-oxidative pent

Externí odkaz: https://doaj.org/article/54e4abc4188c4609baed834f3f363f66

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

Autor: Douglas E. Biancur, Joao A. Paulo, Beata Małachowska, Maria Quiles Del Rey, Cristovão M. Sousa, Xiaoxu Wang, Albert S. W. Sohn, Gerald C. Chu, Steven P. Gygi, J. Wade Harper, Wojciech Fendler, Joseph D. Mancias, Alec C. Kimmelman

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Glutaminase inhibition (GLSi) has promising activity against certain cancers. Here, the authors show that GLSi has no effect on multiple mouse models of pancreatic cancer and characterize the metabolic pathways activated in response to GLSi whose con

Externí odkaz: https://doaj.org/article/3c1c97f9f96f44b8b385caffd639b374