Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Aleš Zadražil"'
Publikováno v:
Powder Technology. 395:743-757
Dissolution testing is widely used to measure the rate of drug release and predict its in-vivo behavior. The release rate can be controlled by adjusting the particle size distribution (PSD). However, experimental investigation of various particle siz
Publikováno v:
ACS applied bio materials. 4(6)
Lipid bilayers are the basic structural components of all living systems, forming the membranes of cells, sub-cellular organelles, and extracellular vesicles. A class of man-made lipidic vesicles called multilobed magnetic liposomes (MMLs) is reporte
Autor:
Ondřej Navrátil, Denisa Lizoňová, Karolína Slonková, Lucie Mašková, Aleš Zadražil, David Sedmidubský, František Štěpánek
Publikováno v:
Colloids and surfaces. B, Biointerfaces. 217
Drug depot systems have traditionally relied on the spontaneous dissolution and diffusion of drugs or prodrugs from a reservoir with constant exposure to the surrounding physiological fluids. While this is appropriate for clinical scenarios that requ
Autor:
Martin Krov, Ondřej Rychecký, Maximilián Prachár, Aleš Zadražil, Rudolf Šrámek, František Štěpánek
Publikováno v:
Powder Technology. 411:117944
Publikováno v:
European Journal of Pharmaceutical Sciences. 124:145-152
Rapid tablet disintegration is a requirement for the efficient dissolution of the active pharmaceutical ingredient (API) from immediate release tablets. From the mechanistic viewpoint, tablet disintegration begins by the wetting of the tablet surface
Autor:
Edith Mawunya Kutorglo, Ladislav Fišer, Miroslav Soos, Dušan Kopecký, Ivona Sedlářová, Aleš Zadražil, Fatima Hassouna
Publikováno v:
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 557:137-145
We report the synthesis of stable conductive macroporous materials by chemical oxidative polymerization of aniline-(2-acrylamido-2-methylpropanesulfonic acid) in the presence of polystyrene nanoparticles (PS-NPs). The presented method allows, without
Autor:
Ondřej Kašpar, A. Pittermannová, Aleš Zadražil, Vlastimil Král, Jérôme Bibette, Nicolas Bremond, A. Hubatová-Vacková, Viola Tokárová, Denisa Lizoňová, Robert Pola, Z. Ruberová, František Štěpánek, Michal Pechar
Publikováno v:
Soft matter. 16(37)
Microfluidics allows precise control of the synthesis of microparticles for specific applications, where size and morphology play an important role. In this work, we have introduced microfluidic chip design with dedicated extraction and gelation sect
Autor:
Josef Beranek, Matěj Novák, Adam Waněk, Tereza Boleslavská, Aleš Zadražil, Zdeněk Grof, Pavel Kovačík, František Štěpánek
Publikováno v:
AAPS PharmSciTech. 19:3414-3424
The problem of designing tablet geometry and its internal structure that results into a specified release profile of the drug during dissolution was considered. A solution method based on parametric programming, inspired by CAD (computer-aided design
Autor:
Miloslav Lhotka, Marek Šoltys, František Štĕpánek, Martin Balouch, Pavel Ulbrich, Aleš Zadražil, Ondřej Kašpar, Pavel Kovačík
Publikováno v:
Chemical Engineering Journal. 334:1135-1147
Despite the wide application interest in mesoporous silica micro- and nano-particles and a number of synthesis routes reported in the literature, the question of chemical engineering scale-up of the synthetic routes has rarely been addressed. The pre
Publikováno v:
Crystal Growth & Design. 17:3700-3706
A novel continuous fluidic method based on extractive crystallization for producing monodisperse spherical crystal aggregates with potential use in pharmaceutical engineering is presented. A model system of aqueous solution containing KCl as the prec